This Combined Synopsis/Solicitation opportunity from Department Of Health And Human Services was posted on May 22, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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Neuropathology characterization for the Brain Atlas Project

Closed

75N98026Q00313Federal

Submission Closed05/28/2026, 09:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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AI Contract Overview

The National Institutes of Health, Office of the Director, is seeking a small business to provide comprehensive neuropathology services in support of the Brain Atlas Project, aimed at advancing understanding of Alzheimer’s disease through detailed cellular-level analysis of human brain tissue. This firm fixed price purchase order, issued under FAR Subpart 12.6 as a competitive combined synopsis/solicitation, is set aside exclusively for small businesses with a NAICS code of 621511 and a size standard of $41.5 million. The contract spans from June 1, 2026, to May 30, 2027, and requires the contractor to process 58 large, multi-piece brain samples, each involving trimming, cassette printing, paraffin embedding for 16 blocks, routine H&E staining, and chromogenic immunostaining on 30 slides per sample using specific biotin-free assays for key pathological markers. All processed blocks, stained slides, and digital images must be delivered, alongside secure digital platform access featuring at least 67 TB of storage, 12 months of image retention, and three user accounts with capabilities to view, annotate, snapshot, and download raw files. The contractor must also provide pickup and delivery services to the NIH campus in Bethesda, Maryland, and complete all services within five to ten business days of sample receipt. Technical acceptability is evaluated as a pass/fail gate, with failure to meet any mandatory requirement—including sample processing capability, digital platform specifications, staffing with trained histology and imaging personnel, a dedicated project manager, and facility and equipment adequacy—resulting in immediate disqualification. Price evaluation follows a Lowest Price Technically Acceptable methodology, meaning the contract will be awarded to the responsible offeror with the lowest price who meets all technical criteria. Proposals must include a technical proposal not exceeding 30 pages with detailed workflows, quality control measures, staffing qualifications, and facility descriptions; a past performance summary with up to three relevant project examples and verification contacts; and a separate, fully itemized price proposal that breaks down labor, materials, scanning, storage, slide preparation, and logistics costs. All offerors must be actively registered in SAM, submit their UEI and TIN, certify small business status, and include the completed FAR 52.212-3 form. Responses are due by May 28, 2026, at 5:00 p.m. EST and must be submitted electronically to

General Info

NIH NIA seeks small business for neuropathology services supporting Alzheimer’s research, firm fixed price.

Agency

Department Of Health And Human Services → National Institutes Of Health OlaoView Agency

Contract Value

$215,567.1

NAICS

621511 - Medical LaboratoriesView NAICS

Place of Performance

Bethesda, MD, USA

Set-Aside

SBA

Awardee

HISTOSERV, INCView Profile

Award Issued Date

06/08/2026, 12:00:00 AM UTC

Documents

(2)

Solicitation 75N98026Q00313 Q and A Document

PDF•q-and-a

Neuropathology Characterization for Brain Atlas Project - Statement of Work

PDF•sow

AI Contract Breakdown

Uniform Contract Format

Timeline

3 updates

PhaseClosed

PostedMay 5

Combined Synopsis

Amendment 1May 19

Contract was updated

Amendment 2May 21

Contract was updated

Amendment 3May 22

Contract was updated

Response DeadlineMay 28

Deadline has passed

Submission Closed

05/28/2026, 09:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → National Institutes Of Health Olao

Contacts1 person available

OfficeBETHESDA, MD, 20892, USA

Organization / Agency

Department Of Health And Human Services → National Institutes Of Health Olao

View Agency Profile

Office AddressBETHESDA, MD, 20892, USA

Contacts

Elaine Estrella

contact@example.gov

Full Description

COMBINED SYNOPSIS / SOLICITATION (COMPETITIVE)

Title: Neuropathology characterization for the Brain Atlas Project

(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested, and a separate written solicitation will not be issued.

(ii) The solicitation number is 75N98026Q00313. This solicitation is issued as a competitive combined synopsis/solicitation for commercial products or commercial services. The Government intends to award a contract or purchase order resulting from this solicitation using full and open competition.

This acquisition is conducted under the authority of FAR 12.603, Streamlined Solicitation for Commercial Products or Commercial Services, and is not expected to exceed the simplified acquisition threshold.

The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, seeks to award a firm fixed price purchase order to the responsible offeror whose proposal represents the best value to the Government.

(iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular (2026-01).

(iv) The associated NAICS code is 621511, and the small business size standard is $41.5 million.

This requirement is set aside for small business

(v) Description of Requirement:

The National Institute on Aging (NIA) requires neuropathology services support of the Brain Atlas project which was established in 2022. NIA’s Center for Alzheimer’s Disease and Related Dementias is working to better understand the differences between healthy brains and brains affected by Alzheimer’s disease at the cellular level. Researchers are working to create a human brain atlas or map of different brain cell types based on their gene activity. Researchers can use this atlas to investigate cell types present in brain regions affected in disease. Many different cells in a diseased brain experience change in their gene expression and downstream intracellular activities. The neuropathology analysis will lead to a better understanding of Alzheimer’s Disease and the prioritization of potential target genes, pathways, and future therapeutics.

Please refer to the Statement of Work (SOW) for additional information.

(vi) Delivery Location:
NIH/NIA
9000 Rockville Pike RM 170
Bethesda, MD 20892
USA

(vii) Period of Performance: June 01, 2026 to May 30, 2027

(viii) The provision at FAR 52.212-1, Instructions to Offerors—Commercial Items, applies to this acquisition. Add any agency-specific instructions as required.

(ix) The provision at FAR 52.212-2, Evaluation—Commercial Items, applies to this acquisition.

(a) The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation represents the best value to the Government, price and other factors considered.

(b) Evaluation Factors:

Technical Acceptability (Pass/Fail)
- Required Sample Processing Capabilities
- Digital Imaging & Data Platform Requirements
Schedule & Turnaround
Deliverables Compliance
Staffing & Key Personnel
Facilities and Equipment
Price Evaluation - Lowest Price Technically Acceptable – (LPTA)

(c) A written notice of award or acceptance of an offer, issued within the time specified in the offer, shall result in a binding contract without further action by either party. The Government reserves the right to accept any offer before the expiration date.

(x) Offerors shall include a completed copy of FAR 52.212-3, Offeror Representations and Certifications—Commercial Items, with their offer.

(xi) FAR 52.212-4, Contract Terms and Conditions—Commercial Items, applies to this acquisition.

(xii) FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders—Commercial Items, applies to this acquisition.

(xiii) Additional contract requirements or terms and conditions, as determined necessary by the Contracting Officer and consistent with customary commercial practices: See Statement of Work (SOW) for additional requirement.

(xiv) The Defense Priorities and Allocations System (DPAS) is not applicable.

(xv) Submission Requirements:
Responses must include sufficient information to demonstrate the offeror’s capability to provide the required product or service. Quotes shall include, at a minimum:

Unit and total price
Shipping and handling costs
Delivery timeframe after award
Delivery terms
F.O.B. point (destination or origin)
Product or catalog numbers (if applicable)
Product/service description

Additional evaluation considerations may include past performance, warranty, lifecycle cost, maintenance availability, and environmental or energy efficiency.

Responses must include the Unique Entity Identifier (UEI), Taxpayer Identification Number (TIN), and business size certification. All offerors must be actively registered in the System for Award Management (SAM) at www.sam.gov.

All responses must be received by May 28, 2026 at 5pm EST and must reference solicitation number 75N98026Q00313 . Responses may be submitted electronically to elaine.estrella@nih.gov and brian.lind@nih.gov .

(xvi) Point of Contact: Elaine Estrella, Contract Specialist, elaine.estrella@nih.gov and Brian Lind, Contract Officer, brian.lind@nih.gov