NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)
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The National Institutes of Health, under the Department of Health and Human Services, is issuing a forecast for the Small Business Technology Transfer Grant (Parent STTR R41/R42), where clinical trials are optional. This opportunity is open to eligible United States small business concerns that possess the research capabilities and technological expertise to support the research and development missions of numerous NIH Institutes and Centers, including the NCI, NIAID, and NIMH, among others. The program supports various application types, including Phase I, Phase II, Direct to Phase II, and Fast-Track submissions, and encourages collaborative investigations that combine specialized expertise. The funding opportunity, identified as PA-27-102, was posted on May 28, 2026, with an official open date of August 5, 2026. Application deadlines are scheduled for September 2026, January 2027, and April 2027. This initiative is categorized under NAICS code 541715 and is designed to provide small businesses with sufficient time to develop meaningful collaborations and responsive projects. Interested parties can contact the NIH Small business Education and Entrepreneurial Development (SEED) office for further information.
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The National Institutes of Health (NIH), including the following NIH Institutes and Centers (ICs): NEI, NHLBI, NHGRI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDCD, NIDCR, NIDDK, NIDA, NIEHS, NIGMS, NIMH, NINDS, NINR, NIMHD, NLM, NCCIH, NCATS, ORIP, NCI and ORWH, intends to publish a Notice of Funding Opportunity (NOFO) to invite eligible United States small business concerns (SBCs) to submit Small Business Technology Transfer (STTR) Phase I, Phase II, Direct to Phase II (NIH only) and Fast-Track (NIH only) applications. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R41/R42 activity code. United States small businesses that have the research capabilities and technological expertise to contribute to the R&D mission(s) of the NIH awarding components identified in this NOFO are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise will be encouraged and these investigators should also begin considering applying for this application.
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