NIH Tetramer Core Facility

The National Institutes of Health, National Institute of Allergy and Infectious Diseases, is soliciting proposals for the NIH Tetramer Core Facility under solicitation number 75N93026R00006, with a response deadline of June 22, 2026. This is a cost-reimbursement, level-of-effort contract with a base period of one year beginning March 21, 2027, and six one-year option periods allowing for a total potential performance period of seven years. The contracting activity is not set aside for small businesses, and the North American Industry Classification System code is 541714. The primary objective is to establish and operate a centralized facility for producing, quality-controlling, and distributing custom-synthesized antigenic peptide/MHC monomeric and tetrameric reagents used to detect, enumerate, and isolate antigen-specific T cells across human, rodent, non-human primate, and other mammalian species. The Contractor must implement advanced genetic cloning and expression techniques to enhance MHC molecule folding, stability, and complex formation, while continuously optimizing processes for reproducibility, scalability, and performance. The contract requires the provision of nine full-time equivalent personnel annually throughout the base and all option periods, along with comprehensive technical and administrative support including detailed documentation, standardized operating procedures, laboratory equipment inventories, validation data, and data management platforms. Deliverables must include MHC expression constructs, cell lines, reagent stocks, and annual reports, all submitted 30 days prior to the end of the contract term. The Contractor must comply with Section 508 accessibility standards for all electronic content, ensuring compliance with Revised 508 Standards (36 C.F.R. 1194.1), and must provide accessibility checklists with final deliverables unless otherwise approved. Annual Section 508 and utilization reports are due by the 30th day of the month following each contract anniversary. The Contractor is also required to meet small business subcontracting goals of 32% for small businesses, and 5% each for small disadvantaged businesses and women-owned small businesses, with 3% each for HUBZone and veteran-owned businesses. All proposals must be submitted via the NIH eCPS website, formatted as single searchable PDFs with strict formatting rules, and must include comprehensive technical, business, and compliance documentation as outlined in 19 attachments. Evaluation will prioritize technical approach (weighted at approximately 9