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Pancreatic Cancer Detection Consortium: Research Units (U01 Clinical Trial Optional)

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PAR-28-056Grant

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The National Institutes of Health, under the Department of Health and Human Services, is soliciting applications for Research Units as part of the Pancreatic Cancer Detection Consortium. This initiative focuses on the early detection of pancreatic ductal adenocarcinoma and the characterization of precursor lesions to identify high-risk patients. Multi-disciplinary teams will be tasked with developing and testing molecular and imaging biomarkers, utilizing machine learning for biomarker discovery, and conducting validation studies. Additionally, these units will collect longitudinal biospecimens to build a comprehensive biorepository. The program emphasizes collaborative efforts, requiring Research Units to share data, ideas, and biospecimens within the consortium. This effort aligns with the NCI's scientific framework to improve screening for populations with genetic predispositions or family histories of the disease. Interested parties must submit their applications by the deadline of November 5, 2029, in accordance with solicitation number PAR-28-056.

General Info

NIH seeks multi-disciplinary teams for pancreatic cancer early detection research by November 2029.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

(1)

PAR-28-056 Pancreatic Cancer Detection Consortium: Research Units

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Timeline

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUSA
Organization / Agency
Department Of Health And Human Services → National Institutes Of Health
Office AddressUSA
Contacts
National Institutes of Health
contact@example.gov
+1 (555) 000-0000

Full Description

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Through this Notice of Funding Opportunity (NOFO), NCI solicits applications for the Research Units (RUs), one of the two scientific components of the Pancreatic Cancer Detection Consortium (PCDC), to conduct research on early detection of pancreatic ductal adenocarcinoma (PDAC) and characterization of its precursor lesions to identify patients who are at high risk of progression to cancer. The PCDC will continue to address one of the four research priorities identified in the NCI's 2014 Scientific Framework for Pancreatic Ductal Adenocarcinoma (PDAC). The PCDC will support research for the development and testing of new molecular and imaging biomarkers for detecting PDAC early and for identifying patients at high risk of PDAC (because of genetic factors, family history and/or the presence of precursor lesions) who could be candidates for early intervention. The PCDC-RUs will consist of multi-disciplinary teams and will undertake studies to: identify and test biomarkers measurable in bodily fluids for early detection of PDAC and/or its precursor lesions; develop molecular- and/or imaging-based markers of pancreatic cysts and determine which lesions are likely to progress to cancer; develop molecular- and/or imaging-based approaches for screening populations at high risk of PDAC; use machine learning and computational approaches towards biomarker discovery and/or validation; and conduct biomarker validation studies. The PCDC-RUs will also collect longitudinal biospecimens for building a biorepository. Each PCDC-RU is expected to participate in collaborative activities with other PCDC-RUs and share ideas, biospecimens, and data within the Consortium.

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