This Solicitation opportunity from Department Of Health And Human Services was posted on October 7, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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ARPA-H Comprehensive Organ System Modeling in Outer Space (COSMOS) Innovative Solutions Opening

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ARPA-H-SOL-26-165Federal

Submission Closed10/07/2026, 09:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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NAICS: 541714

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Solicitation # RFA-RM-27-008

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POSTED

6 days ago

DEADLINE

in 5 months

AI Contract Overview

The Advanced Research Projects Agency for Health (ARPA-H) is seeking proposals under solicitation ARPA-H-SOL-26-165 for the Comprehensive Organ System Modeling in Outer Space (COSMOS) initiative. This program aims to determine if microgravity in Low Earth Orbit (LEO) accelerates tissue aging across brain, cardiac, uterine, and kidney tissues compared to terrestrial rates. If the Tissue Aging Rate in Space (TARIS) is found to significantly exceed the Tissue Aging Rate on Earth (TAROE), the initiative intends to establish a high-throughput, autonomous drug screening platform in LEO to make biomedical research and development more cost-effective and faster than Earth-based methods. The project is structured into two sequential phases: a 27-month Phase I focused on establishing and validating microphysiological systems (MPS) to quantify aging rates, and a 15-month Phase II dedicated to developing age-related pathology models for pro-regenerative drug testing. Key requirements include the use of MPS or organoids for at least 75 percent of experimental samples, the creation of LEO twin experiments, and the establishment of a contractual partnership with at least one Fortune 100 biopharmaceutical company. The program schedule spans FY27 through FY30 and includes two planned space launches in months 39 and 41. Awards will be granted via multiple Other Transaction (OT) Agreements to the most advantageous proposers, including universities, non-profits, and businesses. Evaluation is based primarily on the innovation and feasibility of the technical approach, the potential to transform biomedicine, and the team's expertise in managing costs and schedules. Proposers must adhere to strict administrative requirements, including the BIOSECURE Act, NIH Genomic Data Sharing policies, and specific research security and cybersecurity disclosures. Full proposals are due by October 7, 2026.

General Info

ARPA-H seeks proposals for LEO tissue aging research and autonomous drug screening platforms.

Agency

Department Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance

Set-Aside

NONE

Documents

39 pages · amendment

High

rfp

High

32 pages · rfp

High

7 pages · specifications

High

3 pages · sow

High

1 page · specifications

High

4 pages · specifications

High

12 pages · specifications

High

32 pages · specifications

High

6 pages · specifications

High

q-and-a

Low

q-and-a

Low

AI Contract Breakdown

Uniform Contract Format

Timeline

5 updates

PhaseClosed

PostedSep 16

Solicitation

Notice updatedSep 17

The notice description changed.

Notice updatedSep 21

The notice description changed.

Notice updatedSep 23

The notice description changed.

Notice updatedSep 25

The notice description changed.

Notice updatedOct 7

Response deadline time changed from 6:00 PM UTC to 9:00 PM UTC on Oct 7, 2026. The notice description changed.

Response DeadlineOct 7

Deadline has passed

Submission Closed

10/07/2026, 09:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)

Contacts1 person available

OfficeWashington, DC, 20005, USA

Organization / AgencyDepartment Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)

Office AddressWashington, DC, 20005, USA

Contacts

COSMOS Team

contact@example.gov

Full Description

The Advanced Research Projects Agency for Health (ARPA-H) Comprehensive Organ System Modeling in Outer Space (COSMOS) Initiative aims to definitively prove or disprove if exposure to microgravity in Low Earth Orbit (LEO) truly accelerates tissue aging across brain, cardiac, uterine, and kidney tissue types and across several adult age brackets. Provided Tissue Aging Rate in Space (TARIS) exceeds Tissue Aging Rate on Earth (TAROE) at a rate that exceeds the on Earth breakeven cost for new drug R&D, COSMOS will create a first-in-class platform for fully autonomous, high-throughput drug screening in LEO that would be more cost effective and faster than new drug R&D on Earth.

ARPA-H anticipates multiple Other Transaction awards resulting from this announcement.

Interested parties are invited to download and review the attached COSMOS Innovative Solutions Opening (ISO) ARPA-H-SOL-26-165

Amendment 01 – 17 September 2026: This amendment includes updated hyperlinks and information on the updated Solutions summary portal.

Questions and Answers – 21 September 2026: This Q&A is provided for informational purposes only and does not amend the solicitation. All other questions are due by 23 September 2026 at 5:00PM ET.

Amendment 02 – 23 September 2026: This amendment includes updates to Section 3, COSMOS Details; Section 4, Mandatory Experimental Design; as well as Correction to Figure 2.

Questions and Answers – 25 September 2026: This Q&A is provided for informational purposes only and does not amend the solicitation.

Amendment 03 – 07 October 2026: This amendment extends the submission time, now due 07 October 2026, 5:00pm ET.