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ARPA-H Comprehensive Organ System Modeling in Outer Space (COSMOS) Innovative Solutions Opening

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ARPA-H-SOL-26-165Federal

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

AI Contract Overview

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The Advanced Research Projects Agency for Health (ARPA-H) has issued solicitation ARPA-H-SOL-26-165 for the Comprehensive Organ System Modeling in Outer Space (COSMOS) Initiative. This project seeks to determine if microgravity exposure in Low Earth Orbit accelerates tissue aging in the brain, heart, uterus, and kidneys across various adult age groups. If the aging rate in space significantly exceeds that on Earth, the initiative intends to develop a first-in-class, autonomous, high-throughput drug screening platform in orbit to make pharmaceutical research more cost-effective and efficient than terrestrial methods. Managed by the Department of Health and Human Services, this solicitation is open for responses until October 7, 2026. ARPA-H anticipates granting multiple Other Transaction awards to successful applicants. Interested parties should contact the COSMOS Team for further details regarding this innovative health research effort.

General Info

ARPA-H seeks research on microgravity's effect on aging to develop orbital drug screening.

Agency

Department Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)View Agency

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)View NAICS

Place of Performance

DC

Set-Aside

NONE

Documents

(8)

ATTACHMENT C COSMOS Schedule

XLSX•4 pages•specifications

COSMOS Milestone and Payment Table

XLSX•6 pages•specifications

Attachment A.2 Task Description Document Model

DOCX•3 pages•sow

Attachment A.1 Technical & Management Proposal Model (Vol I)

DOCX•7 pages•specifications

ARPA-H-SOL-26-165 COSMOS ISO

DOCX•32 pages•rfp

Attachment B: COSMOS Eligibility and Conformance Certification Sheet

DOCX•1 page•specifications

COSMOS Administrative and National Policy Requirements

DOCX•12 pages•specifications

COSMOS Cost Proposal Template

XLSX•32 pages•specifications

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Timeline

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)
Contacts1 person available
OfficeWashington, DC, 20005, USA
Organization / Agency
Department Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)
View Agency Profile
Office AddressWashington, DC, 20005, USA
Contacts
COSMOS Team
contact@example.gov

Full Description

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The Advanced Research Projects Agency for Health (ARPA-H) Comprehensive Organ System Modeling in Outer Space (COSMOS) Initiative aims to definitively prove or disprove if exposure to microgravity in Low Earth Orbit (LEO) truly accelerates tissue aging across brain, cardiac, uterine, and kidney tissue types and across several adult age brackets. Provided Tissue Aging Rate in Space (TARIS) exceeds Tissue Aging Rate on Earth (TAROE) at a rate that exceeds the on Earth breakeven cost for new drug R&D, COSMOS will create a first-in-class platform for fully autonomous, high-throughput drug screening in LEO that would be more cost effective and faster than new drug R&D on Earth.


ARPA-H anticipates multiple Other Transaction awards resulting from this announcement.


Interested parties are invited to download and review the attached COSMOS Innovative Solutions Opening (ISO) ARPA-H-SOL-26-165

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