This Solicitation opportunity from Department Of Health And Human Services was posted on January 25, 2022. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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Pharmacology and Toxicology for Therapeutics Program (PTTP)

Awarded

75N95022R00003Federal

Submission Closed02/25/2022, 10:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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NAICS: 541715

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Information Assurance (IA) and Secure Data Exchange SpecialistThis subcontract opportunity for the U.S. Air Force focuses on research and development for Technical Data Package modernization projects. The selected specialist will develop technical frameworks for secure data exchange, conduct feasibility studies on Information Assurance protocols, and design secure transmission workflows. Key deliverables include secure exchange architecture designs and technical feasibility reports intended to support prime contractors. The contract is a Total Small Business Set-Aside under NAICS code 541715, specifically mandating SBIR/STTR compliance for firms with fewer than 500 employees. Due to the sensitive nature of the work, strict adherence to ITAR and EAR regulations is required, and all data handling systems must be CMMC-compliant. Responses are due by November 25, 2026.

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Technical Research Subcontractor / ConsultantThis subcontract opportunity, issued by the U.S. Air Force under the Department of Defense, seeks a Technical Research Subcontractor or Consultant to support prime contractors on Department of War SBIR projects. The selected entity will be responsible for conducting specialized research and technical analysis to determine feasibility, developing methods to meet technical objectives, and delivering comprehensive data and research findings for final reports. The contract is a total small business set-aside under NAICS code 541715, requiring the subcontractor to have fewer than 500 employees. Key compliance requirements include adherence to CMMC standards for handling Controlled Unclassified Information and Federal Contract Information, the implementation of OCI mitigation plans, and strict following of protocols regarding Recombinant DNA or Human and Animal Subjects. Responses are due by November 25, 2026.

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Research Institution Partner (Non-Profit)This subcontract opportunity is for a registered non-profit research institution to partner with prime contractors on U.S. Air Force STTR projects. The primary objective is to conduct core scientific research to evaluate the technical feasibility of cyber resiliency within edge computing environments. Selected partners will be expected to leverage university laboratories, high-performance computing clusters, and specialized academic research software to produce research data, peer-reviewed findings, and contributions to technical reports. The opportunity is designated as a total small business set-aside under the SBIR/STTR mandate for organizations with fewer than 500 employees, falling under NAICS code 541715. Interested parties must submit their responses by November 25, 2026, at 5:00 PM. This effort is managed through the U.S. Department of Defense on behalf of the U.S. Air Force.

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Edge and Fog Computing Architecture SpecialistThis subcontract opportunity for the U.S. Air Force focuses on research and development for cyber resiliency projects, specifically targeting the design of resilient architectures for fog and edge computing devices. The selected provider will be responsible for conducting feasibility studies, establishing technical milestones, and utilizing edge gateways, fog computing nodes, and embedded hardware. Key deliverables include a technical feasibility report and a Final Scientific or Technical Report. The project is a total small business set-aside under NAICS code 541715, requiring the contractor to have fewer than 500 employees. Due to the sensitive nature of the work, strict security compliance is mandatory, including CMMC Level 2 and adherence to NIST SP 800-171 and NIST SP 800-172 standards. Responses are due by November 25, 2026.

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DEADLINE

Research Institution / University Partner (STTR)This subcontract opportunity is for a Research Institution or University Partner to support prime contractors on Department of Defense 2027 SBIR/STTR Phase I projects for the U.S. Air Force. The selected partner will be responsible for performing fundamental research, technical validation, and experiments to determine the feasibility of proposed concepts. Key deliverables include contributing to the Phase I technical volume, providing research data, and submitting detailed technical reports and feasibility findings. The solicitation was posted on October 28, 2026, with a response deadline of November 25, 2026. This is a total small business set-aside under the SBIR/STTR mandate for entities with fewer than 500 employees, falling under NAICS code 541715. The primary objective is to provide the academic and analytical rigor necessary to validate technical concepts during the initial phase of the program.

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Specialized Cleaning Agent DevelopmentThis subcontract for the U.S. Navy involves the research and development of a specialized cleaning agent designed for TDR Tank Level Indicator projects. The selected contractor will analyze contaminants and formulate non-corrosive chemical compositions that are compatible with naval tank materials, with a strict requirement that no hexavalent chromium is used in the process. The project necessitates the use of laboratory facilities for chemical synthesis and material compatibility testing, culminating in the delivery of sample agents and detailed formulation reports. This opportunity is a Total Small Business Set-Aside under NAICS code 541715, specifically adhering to SBIR/STTR mandates for companies with fewer than 500 employees. Interested parties must submit their responses by November 25, 2026, to support prime contractors operating under the U.S. Department of Defense.

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Research Institution Collaborative PartnerThe Research Institution Collaborative Partner subcontract, issued by the U.S. Air Force under the Department of Defense, focuses on primary research and development for STTR projects. The selected partner will be responsible for conducting laboratory research, theoretical modeling, data analysis, and technical validation to assess the feasibility of proposed concepts. Key deliverables include technical reports, research findings, and comprehensive feasibility data. This opportunity is specifically set aside for small businesses under the SBIR/STTR mandate with fewer than 500 employees, and it requires the partner to be a non-profit research institution, such as a university or a Federally Funded Research and Development Center. Interested parties must submit their responses by November 25, 2026.

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Luminescence-Based Sensor Development SpecialistThis subcontract opportunity for the U.S. Air Force involves the research and development of luminescence-based surface measurement techniques specifically for hypersonic ground test facility projects. The selected specialist will be responsible for creating theoretical frameworks, identifying stable luminescent phosphors suitable for non-oxygen environments, and designing optical measurement systems utilizing high-speed sensors and spectrometers. The primary deliverables include comprehensive technical data and feasibility analyses to support prime contractors. This is a Total Small Business Set-Aside under NAICS code 541715, requiring the contractor to have fewer than 500 employees. Due to the nature of the defense work, strict adherence to ITAR/EAR compliance and NIST SP 800-171/CMMC cybersecurity standards is mandatory. Interested parties must submit their responses by November 25, 2026.

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DEADLINE

RF and Signal Processing Engineering ServicesThis subcontract for RF and Signal Processing Engineering Services supports U.S. Air Force telemetry projects by providing research and design for signal synchronization architectures. The scope of work includes developing synchronization algorithms, analyzing signal drift, and designing clock distribution networks utilizing tools such as MATLAB/Simulink or ADS. The primary deliverables consist of synchronization architecture designs and technical feasibility reports. This opportunity is a total small business set-aside under NAICS code 541715. Due to the nature of the work, contractors must be U.S. citizens to comply with ITAR/EAR export controls and must maintain CMMC compliance for handling Controlled Unclassified Information. Responses are due by November 25, 2026.

U.S. Air Force

POSTED

about 4 hours ago

DEADLINE

in 28 days

General Info

Agency

Department Of Health And Human Services → National Institutes Of Health Nida

Contract Value

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Set-Aside

NONE

Awardee

UNIVERSITY OF ILLINOIS

Award Issued Date

09/30/2022, 12:00:00 AM UTC

Documents

Attachment No. 20 – Employee Separation Checklist

other

Low

Amendment0001_75N95022R00003-S.pdf

Attachment+No.+10+Business+Proposal+Budget+Templates.xlsx

Attachment+No.+11+Offeror+Pts+of+Contact.pdf

Attachment+No.+12+Wage+Determination+November+2021.pdf

Attachment+No.+13+Disclosure+of+Lobbying.pdf

Attachment+No.+13+Disclosure+of+Lobbying_revised.pdf

Attachment+No.+14+NIH+Customer+Perf+Survey.pdf

Attachment+No.+15+NIH%28RC%29-2-2.pdf

Attachment+No.+15+NIH%28RC%29-2-2_revised.pdf

Attachment+No.+16+NIH+%28RC%29-4.pdf

Attachment+No.+17+Privacy+Act+SORN+09-25-0124.pdf

Attachment+No.+18+Nondisclosure+Agreement.pdf

Attachment+No.+19+Suitability+Roster.xlsx

Attachment+No.+21+Electronic+Invoicing+Instructions+20210210.pdf

Attachment+No.+22+Project+Objectives+NIH-1688-1.pdf

Attachment+No.+22+Project+Objectives+NIH-1688-1_revised.pdf

Attachment+No.+23+Financial+Questionnaire.pdf

Attachment+No.+23+Financial+Questionnaire_revised.pdf

Attachment+No.+2+Propsal+Intent+Response+Sheet.pdf

Attachment+No.+3+Statement+of+Work_revised.pdf

Attachment+No.+4+Section+K+Reps.pdf

Attachment+No.+5+Technical+Proposal+Budget+Templates_revised.xlsx

Attachment+No.+5+Technical+Proposal+Budget+Templates.xlsx

Attachment+No.+6+Summary+of+Related+Activities.pdf

Attachment+No.+7+VAS+Contracts+worksheet.pdf

Attachment+No.+8+Propos+Summary+NIH-2043.pdf

Attachment+No.+8+Propos+Summary+NIH-2043_revised.pdf

Attachment+No.+9+Small+Business+Subcontracting+Plan.pdf

RFP+75N95022R00003+PTTP+Ramp-On.pdf

RFP+75N95022R00003+PTTP+Ramp-On_revised.pdf

AI Contract Breakdown

Uniform Contract Format

Contract not broken down yet

CLEATUS splits the solicitation into Uniform Contract Format (UCF) sections: scope, pricing, deliverables, and evaluation criteria.

Timeline

10 updates

PhaseAwarded

PostedOct 28

Presolicitation

Notice updatedNov 12

Response deadline changed from Nov 12, 2021 to Nov 17, 2021. The notice description changed.

Deadline changedNov 18

Response deadline changed from Nov 17, 2021 to Nov 19, 2021.

Notice updatedNov 18

The notice description changed.

Notice updatedNov 23

Response deadline changed from Nov 19, 2021 to Nov 24, 2021. The notice description changed.

Notice updatedNov 24

Response deadline changed from Nov 24, 2021 to Dec 1, 2021. The notice description changed.

Notice updatedDec 1

Response deadline changed from Dec 1, 2021 to Dec 3, 2021. The notice description changed.

Notice updatedDec 4

Response deadline changed from Dec 3, 2021 to Dec 7, 2021. The notice description changed.

Notice updatedDec 9

Response deadline changed from Dec 7, 2021 to Jan 3, 2022. The notice description changed.

Notice updatedDec 20

The notice description changed.

Type ChangedJan 4

Presolicitation → Solicitation

Deadline changedJan 25

Response deadline changed from Feb 4, 2022 to Feb 25, 2022.

AwardedSep 30

Contract was awarded

Submission Closed

02/25/2022, 10:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → National Institutes Of Health Nida

Contacts2 people available

OfficeBethesda, MD, 20892, USA

Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health Nida

Office AddressBethesda, MD, 20892, USA

Contacts

Sneha Singh

Nancy Lamon-Kritikos

Full Description

The National Institute on Neurological Disorders and Stroke (NINDS) is pursuing the Ramp-On of Multiple Award Indefinite Delivery/Indefinite Quantity (IDIQ) type contracts to assess the pharmacokinetics, toxicology and safety of promising compounds to support their eventual use as therapeutics. Awardees will support the Pharmacology and Toxicology for Therapeutics Program (PTTP) in all preclinical pharmacology and toxicology testing needed to inform lead discovery and the selection of a clinical candidate. Awardees will also support the NINDS in all comprehensive studies needed for regulatory filings such as FDA Investigational New Drug (IND) applications to allow for clinical evaluation of the candidates. If you are interested in this opportunity and wish to be considered for award, please review all attachments and submit all requested information and documentation. If you have questions regarding any of the contents of this Request for Proposals (RFP), please reach out to the Government's identified points of contact.

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Pharmacology and Toxicology for Therapeutics Program (PTTP)

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