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Protein Engineering and Modular Domain Design

Active

Federal

Response Deadline12/31/2026, 12:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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This subcontract, titled Protein Engineering and Modular Domain Design, supports prime contractors on projects for the DARPA Biological Technologies Office within the Department of Defense. The scope of work involves the design and engineering of bio-compatible, modular protein domains, specifically focusing on the development of signal transduction mechanisms for in vivo expression and novel domains that allow for rapid, repeatable protein regulation. The project requires specialized expertise in protein engineering and domain design to ensure all deliverables meet specific kinetic metrics. The final outputs of the contract consist of engineered protein domain sequences and detailed structural designs. The solicitation was posted on July 21, 2026, with a response deadline of December 31, 2026, under NAICS code 541715.

General Info

DARPA subcontract for engineering bio-compatible modular protein domains and signal transduction mechanisms.

Agency

Department Of Defense → Defense Advanced Research Projects Agcy

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

VA

Set-Aside

NONE

Documents

This scope was carved out of DARPA-SN-26-89.

The full solicitation package (2 documents), including the RFP, is on the prime solicitation, not on this scope.

View the prime solicitation

Non-Optical Methods for High Speed Protein Control

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Timeline

PostedJul 21

subcontract

Response DeadlineDec 31

Submission deadline

Response Deadline

12/31/2026, 12:00:00 PM UTCin 2 months

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Organization & Contact Information

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AgencyDepartment Of Defense → Defense Advanced Research Projects Agcy

ContactsNo contacts available

OfficeN/A

Organization / AgencyDepartment Of Defense → Defense Advanced Research Projects Agcy

Office AddressN/A

ContactsNo contact information available

Full Description

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Performs the design and engineering of bio-compatible, modular protein domains for prime contractors on DARPA Biological Technologies Office projects. Designs novel protein domains for rapid, repeatable protein regulation and develops signal transduction mechanisms for in vivo expression. Requires expertise in protein engineering and domain design to meet specific kinetic metrics. Delivers engineered protein domain sequences and structural designs.

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