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Recombinant Antibody Discovery & Engineering Services

Active

Federal

Response Deadline08/03/2026, 01:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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The contract involves the discovery, humanization, and engineering of single domain antibodies designed to penetrate the blood-brain barrier using phage and yeast display platforms. This effort includes advanced antibody optimization through affinity maturation to enhance binding strength and specificity, as well as comprehensive stability testing to ensure functional integrity under physiological conditions. The work is scientifically focused on developing recombinant antibody formats capable of crossing the blood-brain barrier, a critical step for therapeutic applications targeting neurological diseases. This subcontract, issued by the National Institutes of Health under the Department of Health and Human Services, is classified under NAICS code 541714 for research and development in the physical, engineering, and life sciences. The opportunity was posted on July 24, 2026, with a response deadline of August 3, 2026. Performance is expected to take place in Bethesda, Maryland, 20892. The project does not specify a set-aside type or point of contact details, and the full solicitation can be accessed via the provided SAM.gov link for additional procedural or submission guidelines.

General Info

Developing blood-brain barrier-penetrating antibodies via phage/yeast display for neurological therapeutics in Bethesda, Maryland.

Agency

Department Of Health And Human Services → National Institutes Of Health OlaoView Agency

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)View NAICS

Place of Performance

Bethesda, MD, 20892, USA

Set-Aside

NONE

Documents

(0)

No documents available

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Timeline

PostedJul 24

subcontract

Response DeadlineAug 3

Submission deadline

Response Deadline

08/03/2026, 01:00:00 PM UTCin 9 days

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health Olao

ContactsNo contacts available

OfficeN/A

Organization / Agency

Department Of Health And Human Services → National Institutes Of Health Olao

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Office AddressN/A

ContactsNo contact information available

Full Description

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Discovery, humanization, and engineering of single domain antibodies for blood-brain barrier penetration using phage/yeast display platforms, including affinity maturation and stability testing.

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