Resistance Mitigation and Viral Escape Modeling

This subcontract focuses on the computational and experimental evaluation of viral resistance potential specifically targeting filoviruses, with the goal of designing antiviral agents that possess high genetic barriers to resistance. The project aims to understand and mitigate viral escape mechanisms through sophisticated modeling and laboratory assessments, thereby enhancing the effectiveness and durability of antiviral treatments. The work supports efforts to combat filovirus-related diseases by predicting potential resistance pathways and informing the development of therapeutics that are less susceptible to being undermined by viral mutations. Issued by the Department of Health and Human Services under the BARDA umbrella, this opportunity is classified under the NAICS code 541715, relating to research and development in the physical, engineering, and life sciences. The solicitation does not specify a set-aside status and has a response deadline of mid-July 2026. Though detailed location and contact information are not provided, the subcontract is poised to contribute valuable insights and tools for public health preparedness and biodefense through advanced scientific research and antiviral design strategies.