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Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0

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Contract Overview

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AI Contract Overview

The National Institute of Arthritis and Musculoskeletal and Skin Diseases, alongside other NIH Institutes and Centers, is forecasting a Notice of Funding Opportunity for the Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0 initiative. This effort is part of the congressionally mandated NIH Helping to End Addiction Long Term initiative and aims to refine the mapping of sensory neuron innervation across various articular and peri-articular tissues, such as bone, cartilage, and muscle, to better understand the mediation of joint pain. The program seeks to expand upon previous progress by enhancing clinical pain phenotyping through multimodal profiling of diverse patient samples and implementing new preclinical modeling methodologies. Key priorities include testing novel joint-targeted candidates, focusing on peri-articular tissues, validating methods in human samples, and developing integrated joint atlases that combine imaging and molecular data. While applications are not yet being solicited, the NIH encourages multidisciplinary collaborations among experts in neurobiology, pain science, data science, orthopedics, and rheumatic disease.

General Info

NIAMS plans NOFO for RE-JOIN Consortium to advance joint pain research and novel treatments.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

(0)

No documents available

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Timeline

PostedJan 22

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → National Institutes Of Health

Contacts1 person available

OfficeUSA

Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health

Office AddressUSA

Contacts

National Institute of Arthritis and Musculoskeletal and Skin Diseases

contact@example.gov

Full Description

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), in conjunction with other NIH Institutes and Centers (ICs) as a part of the congressionally mandated NIH Helping to End Addiction Long Term (HEAL) initiative intends to publish a Notice of Funding Opportunity (NOFO) to leverage and accelerate the progress achieved in the Restoring Joint Health and Function to Reduce Pain (RE-JOIN) Consortium.

The NOFO aims to more fully refine and map the innervation of the different articular and peri-articular tissues that collectively form the joint (including bone, cartilage, synovium, joint capsule, ligament, tendon, fascia and muscle), by sensory neurons that mediate the sensation of pain.

The NOFO seeks to expand initial and ongoing efforts by:

Enhancing clinical pain phenotyping with multimodal profiling of new and expanded patient samples across life span and disease conditions (i.e., other musculoskeletal and/or rheumatic conditions associated with joint pain beyond knee and temporomandibular joint (TMJ)).
Expanding to new preclinical and New Approach Methodologies (NAMs) in modeling joint disease.
Preclinical testing of novel joint-targeted candidates identified in RE-JOIN 1.0.
Focusing on peri-articular tissues in joint pain, such as vasculature, synovium, adipose, myofascial tissue, etc.
Prioritizing secondary analysis of datasets and/or validation of methods and approaches in human samples.
Improve data integration by developing/enhancing joint atlases that will enable integration of imaging and molecular datasets.

Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful multidisciplinary collaborations and responsive projects. Investigators with expertise and insights in neurobiology, pain science, data science, orthopedics, rheumatic disease, etc. are encouraged to consider applying for this NOFO.