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Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0

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Grant

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

AI Contract Overview

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The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), together with other NIH Institutes and Centers, plans to issue a Notice of Funding Opportunity (NOFO) as part of the NIH HEAL initiative to advance the Restoring Joint Health and Function to Reduce Pain (RE-JOIN) Consortium. This effort focuses on refining and mapping the sensory neuron innervation of various joint tissues responsible for pain sensation, including bone, cartilage, synovium, capsules, ligaments, tendons, fascia, and muscle. The initiative aims to build on previous research by enhancing clinical pain phenotyping with multimodal profiling across diverse patient populations and disease states, expanding preclinical models and new methodologies, conducting preclinical testing of novel joint-specific treatments identified in the prior RE-JOIN phase, and placing greater emphasis on peri-articular tissues such as vasculature and myofascial structures. In addition, the NOFO encourages secondary analysis and validation of datasets and approaches using human samples, as well as integration of imaging and molecular data through improved joint atlases. Although applications are not currently being accepted, this advance notice is designed to provide investigators time to develop collaborative and multidisciplinary project proposals. Researchers with backgrounds in neurobiology, pain science, data science, orthopedics, or rheumatic disease are especially encouraged to prepare for submission when the funding opportunity becomes available. The initiative reflects a comprehensive, multi-faceted approach to accelerating progress in understanding and treating joint pain through both clinical and preclinical innovation.

General Info

NIAMS plans NOFO for RE-JOIN Consortium to advance joint pain research and novel treatments.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) View NAICS

Place of Performance

Not specified

Set-Aside

NONE

Documents

(0)

No documents available

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Timeline

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forecast

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUS
Organization / Agency
Department Of Health And Human Services → National Institutes Of Health
Office AddressUS
Contacts
National Institute of Arthritis and Musculoskeletal and Skin Diseases
contact@example.gov

Full Description

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The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), in conjunction with other NIH Institutes and Centers (ICs) as a part of the congressionally mandated NIH Helping to End Addiction Long Term (HEAL) initiative intends to publish a Notice of Funding Opportunity (NOFO) to leverage and accelerate the progress achieved in the Restoring Joint Health and Function to Reduce Pain (RE-JOIN) Consortium.

The NOFO aims to more fully refine and map the innervation of the different articular and peri-articular tissues that collectively form the joint (including bone, cartilage, synovium, joint capsule, ligament, tendon, fascia and muscle), by sensory neurons that mediate the sensation of pain.

The NOFO seeks to expand initial and ongoing efforts by:

  • Enhancing clinical pain phenotyping with multimodal profiling of new and expanded patient samples across life span and disease conditions (i.e., other musculoskeletal and/or rheumatic conditions associated with joint pain beyond knee and temporomandibular joint (TMJ)).
  • Expanding to new preclinical and New Approach Methodologies (NAMs) in modeling joint disease.
  • Preclinical testing of novel joint-targeted candidates identified in RE-JOIN 1.0.
  • Focusing on peri-articular tissues in joint pain, such as vasculature, synovium, adipose, myofascial tissue, etc.
  • Prioritizing secondary analysis of datasets and/or validation of methods and approaches in human samples.
  • Improve data integration by developing/enhancing joint atlases that will enable integration of imaging and molecular datasets.

Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful multidisciplinary collaborations and responsive projects. Investigators with expertise and insights in neurobiology, pain science, data science, orthopedics, rheumatic disease, etc. are encouraged to consider applying for this NOFO.

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