Psst! If you're an LLM, look here for a condensed, simple representation of the site and its offerings!

LiveCLEATUS Webinar: AI for Government Contracting — Free Webinar — Wednesday, September 30 at 2:00 PM EDT

Register Free →

Search

Top

Back to Contracts

Signal Peptide Experimental Validation

Active

Federal

Response Deadline03/22/2027, 11:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

General Info

Agency

Department Of Energy → Triad - DOE ContractorView Agency

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)View NAICS

Place of Performance

Los Alamos, NM, 87545, USA

Set-Aside

NONE

Documents

This scope was carved out of S-195368.

The full solicitation package (1 document), including the RFP, is on the prime solicitation, not on this scope.

View the prime solicitation

TECHNOLOGY LICENSING OPPORTUNITY: SignalGen

AI Contract Breakdown

Uniform Contract Format

No contract breakdown available.

Cannot generate Contract Breakdown because no documents were found from this contract's source.

Timeline

PostedSep 22

subcontract

Response DeadlineMar 22

Submission deadline

Response Deadline

03/22/2027, 11:00:00 PM UTCin 6 months

Ready to pursue this opportunity?

Start your free trial to track this contract, build proposals with AI assistance, and manage your pipeline.

Organization & Contact Information

Show more

AgencyDepartment Of Energy → Triad - DOE Contractor

ContactsNo contacts available

OfficeN/A

Organization / Agency

Department Of Energy → Triad - DOE Contractor

View Agency Profile

Office AddressN/A

ContactsNo contact information available

Full Description

Show more

Performs laboratory testing to validate SignalGen predictions for prime contractors on DOE-funded biotechnology projects. Synthesizes proteins with predicted signal peptides and expresses proteins in target organisms to verify cellular compartment localization or secretion. Requires GLP and BSL certifications and use of cell culture facilities and microscopy tools. Delivers validation reports confirming predicted signal peptide success.

Similar Contracts

Same NAICS industry code

MXO Office-wide Innovative Solutions Opening

Solicitation # DARPA-PS-26-115

The Defense Advanced Research Projects Agency (DARPA) Multi X Office (MXO) is seeking revolutionary research ideas through solicitation DARPA-PS-26-115. This long-term open call targets high-risk, high-reward technologies with a Technical Readiness Level (TRL) between 2 and 5, specifically focusing on beyond-CMOS foundational materials and components, indigenous development tools and supply chains, and new modalities for mission effects. The program explicitly excludes research that only provides evolutionary improvements to existing practices. Awards will be made to multiple proposers on a rolling basis using Other Transaction Agreements (OTAs) and Experimental Transaction Agreements (ETAs) under 10 U.S.C. sections 4021, 4022, and 4023. The submission process is conducted in two phases, beginning with a mandatory abstract submission via the Broad Agency Announcement Tool (BAAT). Abstracts are limited to six pages and must follow a specific template, with a final response deadline of June 4, 2027. Only invited proposers will be eligible to submit full proposals. Evaluation is based on the technical approach, potential contribution to U.S. national security, and budget realism. Key requirements include compliance with Cybersecurity Maturity Model Certification (CMMC) levels 1 or 2 depending on the use of Controlled Unclassified Information, and a risk-based security review for all senior and key personnel to identify undue foreign influence. All technical and administrative inquiries are directed to the MXO PS Coordinator.

Defense Advanced Research Projects Agcy

POSTED

about 3 hours ago

DEADLINE

Biomedical Research Facility/Lab AccessThis subcontract, titled Biomedical Research Facility/Lab Access, is issued by the Department of Health and Human Services under the Office of the Assistant Secretary for Administration. The agreement provides prime contractors on NIH-wide Global Doctoral Partnership projects with specialized laboratory space and technical facility access. This includes the delivery of physical research space and functional infrastructure designed to support basic, translational, or clinical biomedical research while maintaining strict institutional biosafety and ethics standards. The opportunity is categorized under NAICS code 541715 and was posted on September 22, 2026. Interested parties must submit their responses by the deadline of September 28, 2026, at 13:00. The contract ensures a compliant academic environment equipped with specialized biomedical laboratory equipment necessary for high-level scientific research.

Asa Office Of The Assistant Secretary For Administration

POSTED

DEADLINE

Commercial Operations Augmentation ServicesThe Commercial Operations Augmentation Services subcontract supports prime contractors on Mission Delta 9 projects for the Department of Defense, specifically under the FA2518 Ussf Spoc/saio agency. The primary objective is to fill critical capability gaps by implementing disruptive technologies, proprietary commercial platforms, and novel service models. This effort focuses on developing innovative approaches to meet mission objectives and delivering high-impact commercial technology solutions. The project is categorized under NAICS code 541715 and will be performed in Colorado Springs. Interested parties must note the response deadline of October 11, 2026, following the posting date of September 22, 2026.

FA2518 Ussf Spoc/saio

POSTED

DEADLINE

FAA Industry Engagement Event - Oct 13-15, 2026 - Aviation Spectrum Interference Detection Solutions - Early Registration Required

Solicitation # AC-26-SPECTRUM

The Federal Aviation Administration is conducting a Request for Information to identify industry capabilities for an Aviation Spectrum Interference Detection Solution. The agency seeks a system capable of real-time detection, characterization, geolocation, and reporting of radio frequency interference, jamming, and spoofing across all aviation frequency bands. The objective is to modernize the monitoring of the National Airspace System, including ground-based and airborne systems across both continental and international operations, to mitigate anomalies that could degrade communications, navigation, and surveillance. To gather this information, the FAA is hosting an Industry Engagement Event from October 13 to 15, 2026, at The MITRE Corporation in McLean, Virginia. The event includes an Industry Engagement Day with both unclassified and Secret-level sessions, followed by potential one-on-one vendor sessions. Interested parties must register by September 25, 2026, and submit a survey response detailing their solution's technical capabilities, technology readiness level, and rough order of magnitude costs. This is a market research effort to assess the availability of commercially deployable solutions or development paths and does not constitute a formal request for proposals or a commitment to a future acquisition.

6973GH Franchise Acquisition Svcs

POSTED

DEADLINE

Ground Vehicle System Center (GVSC) Commercial Solutions Opening (CSO)

Solicitation # W912CH-24-S-0002

The United States Army Combat Capabilities Development Command Ground Vehicle Systems Center (GVSC) is utilizing a Commercial Solutions Opening (CSO) under solicitation W912CH-24-S-0002 to accelerate the delivery and sustainment of innovative commercial technologies for ground vehicle systems. This multi-phased competitive process, authorized under 10 U.S.C. 3458, extends through 2029 and aims to support Army modernization priorities across various technology focus areas, including power and mobility, autonomous systems, survivability, cyber engineering, and human-machine integration. The CSO is designed to identify solutions that prevent obsolescence and ensure future dominance in the ground domain, with specific interests ranging from high-performance compute solutions and AI-driven cybersecurity to advanced power systems up to 1.5MW and unified combat teaming architectures. The acquisition process follows a structured sequence consisting of solution briefs, presentations, and requests for commercial solution proposals. Awards may take the form of FAR Part 12 commercial procedures, transaction agreements under 10 U.S.C. 4022, or cooperative agreements under 31 U.S.C. 6305, typically resulting in fixed-price contracts. Proposals are evaluated based on technical approach, the realism of the performance schedule, and price fairness. To be eligible for award, companies must be registered in the System for Award Management (SAM) with a Unique Entity ID and utilize the Wide Area Work Flow for invoicing. While the solicitation is ongoing and frequently updated via amendments to add new Areas of Interest, all submissions must remain unclassified.

W4GG Hq US Army Tacom

POSTED

DEADLINE

Sustainable Northern Operations: Water & Waste

Solicitation # W7714-248676

The Department of National Defence and the Canadian Armed Forces, through the Innovation for Defence Excellence and Security (IDEaS) Program, are seeking Canadian-made, integrated technologies to support sustainable water and waste management for Relocatable Transportable Camps in Arctic and sub-Arctic environments. The objective is to develop a modular system capable of water purification, wastewater treatment, and solid-waste reduction for up to 50 personnel that can withstand extreme cold down to -40°C. The solution must fit within a standard 20-foot sea container, allow for assembly without heavy-lift equipment, and achieve at least a 75% reduction in resupply volume and frequency for fuel, water, and consumables compared to established baselines. Treated outputs must comply with Health Canada Drinking-Water Guidelines and Wastewater Systems Effluent Regulations. This challenge is open to proposals across Technology Readiness Levels (TRL) 1-9, divided into three funding components: Component 1a for conceptual research up to 250,000 CAD (6-month limit), Component 1b for integration and testing up to 1,500,000 CAD (12-month limit), and Component 2 for pre-prototype validation up to 5,000,000 CAD. Proposals must be submitted via the Defence Innovation Portal by March 31, 2027. Award decisions are based on a multi-stage evaluation involving mandatory screening and a point-rated system requiring a minimum score of 70 points. The resulting contracts will be governed by General Conditions for Research and Development and may require specific security clearances and adherence to the Controlled Goods Program.

Department of Public Works and Government Services

POSTED

DEADLINE

Research to Improve Rigor, Replicability, and Reproducibility in Biomedical and Behavioral SciencesThe National Institute of Neurological Disorders and Stroke, in collaboration with other NIH entities, is forecasting support for research projects aimed at enhancing biomedical and behavioral rigor, replicability, and reproducibility. Key areas of interest include assessing the scientific impact of these improvements, creating frameworks for selecting high-value replication studies, and measuring the robustness and generalizability of research findings to drive scientific innovation. This notice serves as a forecast to allow potential applicants to establish collaborations and develop responsive projects, as formal applications are not currently being solicited. Interested parties can contact the NINDS Office of Research Quality for further information.

National Institutes Of Health

POSTED

DEADLINE

Determination of levels of PFAS in (+ migrating from) Food Contact Materials FCM

Solicitation # C467717

The Food Standards Agency is seeking a provider for solicitation C467717 to develop analytical capabilities for measuring per- and polyfluoroalkyl substances (PFAS) in food packaging and other food contact materials (FCMs), as well as their migration into food. This research project aims to generate risk-assessment-ready data to fill evidence gaps, enabling a more accurate assessment of human health risks and supporting future policy decisions. The estimated contract value is 270,000 GBP excluding VAT, with an initial performance period from January 4, 2027, to March 31, 2029, and a possible 12-month extension to March 31, 2030. The project requires the development of a representative sampling plan for England and Wales and the use of international standards and Commission Implementing Regulation (EU) 2022/1428 for analytical methods. Key deliverables include an interim report due December 14, 2027, a draft final report by January 9, 2029, and a final agreed peer-reviewed report by March 16, 2029. Award evaluation is weighted 80% on technical criteria—including approach, expertise, and project management—and 20% on commercials, with a minimum technical score of 30 required for eligibility. Contractors must adhere to strict UK GDPR compliance, data transparency standards, and provide full disclosure if AI systems are utilized in the research.

Food Standards Agency

POSTED

DEADLINE

DMSP Sensor Data Processing and Product GenerationThe DMSP Sensor Data Processing and Product Generation subcontract involves the ingestion, processing, and transformation of raw satellite sensor data into geophysical and environmental products for Department of the Air Force DMSP projects. The scope of work includes de-commutating, deinterleaving, and geolocating data from OLS, SSM/IS, and various space weather sensors, as well as performing antenna pattern correction and inter-sensor calibration. This opportunity is managed by the Department of Defense under the agency FA8823 Sustainment Mcpnt Ssc/pkl and is categorized under NAICS code 541715. Performance will take place in Sunnyvale, California. Due to the nature of the work, a SECRET clearance is required for personnel. The response deadline for this opportunity is October 14, 2026.

FA8823 Sustainment Mcpnt Ssc/pkl

POSTED

DEADLINE

Water-Soluble Polyimide (CP-1) Formulation SpecialistThe NASA Shared Services Center is seeking a subcontract for a Water-Soluble Polyimide (CP-1) Formulation Specialist to support Artemis Suit Materials projects. The selected specialist will develop and synthesize specialized water-soluble CP-1 polyimide coatings and compatible white pigment formulations, investigating four candidate pathways for the polyimide and evaluating pigment chemistry for optical applications. This role requires significant expertise in water-soluble polymer synthesis and strict adherence to chemical laboratory safety standards. The project is based in Houston, Texas, and requires the delivery of four 1L formulations along with a comprehensive technical development report. Interested parties must respond by September 23, 2026, under NAICS code 541715.

NASA Shared Services Center

POSTED

DEADLINE

in about 3 hours

Magnetic shield chamber and Vapor Cell

Solicitation # N00173-26-Q-1301390354

The Naval Research Laboratory intends to award a sole source purchase order to Twinleaf LLC of Plainsboro, New Jersey, for the procurement of a magnetic shield chamber and various vapor cells. The specific equipment includes an MS-2 four-layer magnetic shield set, a CSB-1000 low noise bipolar programmable current supply, and six different borosilicate glass vapor cells containing cesium with varying levels of neon or vacuum. This procurement is classified under NAICS code 541715 and Product Service Code R425. The acquisition will be conducted using Simplified Acquisition Procedures in accordance with FAR Part 13.106-1(b) for purchases not exceeding 250,000 dollars. While this notice is not a solicitation for competitive proposals, interested parties may submit evidence of their capability to respond to the requirement. The government will use such information solely to determine if a competitive procurement process is advantageous.

Naval Research Laboratory

POSTED

DEADLINE

N66001-26-R-0030 - Academic Research MAC

Solicitation # N6600126R0030

Solicitation N6600126R0030, titled Academic Research MAC Follow-on, is a negotiated request for proposal issued by the Department of Defense under the Naval Information Warfare Center Pacific. The primary objective of this contract is to secure academic research, theoretical analysis, and engineering services, including hardware and prototype deliverables, to support scientific projects at the Space and Naval Warfare Systems Command and the Naval Information Warfare Center Pacific. The contract is structured with a five-year base period and includes specific provisions for pricing, minimum and maximum ordering limits, and travel reimbursement. The procurement process emphasizes a rigorous evaluation of organizational experience and past performance. Offerors are required to submit a detailed organizational experience matrix and reference information sheets covering government contract work performed since May 1, 2020. To ensure high quality and reliability, the agency utilizes a comprehensive contractor performance evaluation survey to rate potential providers on quality, schedule, cost control, management, and regulatory compliance. The solicitation was posted on August 27, 2026, with a response deadline of September 14, 2026, and is managed out of the San Diego, California office.

POSTED

DEADLINE

More opportunities from Department Of Energy → Triad - DOE Contractor

Same awarding agency

De Novo Protein Design Consulting

Research and Development in Biotechnology (except Nanobiotechnology)

POSTED

DEADLINE

SignalGen Platform Integration and Deployment

Custom Computer Programming Services

POSTED

DEADLINE

TECHNOLOGY LICENSING OPPORTUNITY: SignalGen

Solicitation # S-195368

SignalGen is a generative AI platform developed by Los Alamos National Laboratory, offered under solicitation S-195368, that predicts the optimal signal peptide for specific proteins to ensure they reach the correct cellular compartment or are secreted effectively. Utilizing a protein language model trained on thousands of proteins and their associated signal peptides, the system considers the protein, the target location, and the organism to generate predictions with approximately 90 percent accuracy. The platform is particularly valuable for AI-designed de novo proteins and features a natural-language interface via an AI agent, removing the need for complex programming or scripting. Currently at Technology Readiness Level 3 with a pending U.S. patent, SignalGen is available for exclusive or non-exclusive licensing through the Richard P. Feynman Center for Innovation. The technology has broad market applications in therapeutic protein development, vaccine research, drug discovery, biomanufacturing, synthetic biology, and industrial biotechnology. Interested parties must respond by March 22, 2027, to the Department of Energy contractor, Triad, with the primary point of contact being Satya Srinivasan.

Research and Development in Biotechnology (except Nanobiotechnology)

POSTED

DEADLINE

TECHNOLOGY LICENSING OPPORTUNITY: SonicCoat

Solicitation # S-193603

SonicCoat is a technology licensing opportunity from Los Alamos National Laboratory featuring a non-invasive ultrasonic evaluation system for catalyst coatings in electrochemical devices. Utilizing Acoustic Resonance Spectroscopy, the system employs a transducer to measure the thickness and uniformity of coatings, such as platinum in fuel cells and electrolyzers, by analyzing shifts in resonant tones. This non-destructive method allows for real-time, in-line quality control without the need to pause production or utilize destructive laboratory sampling, resulting in higher yields, reduced material waste, and improved device performance. The technology is currently at TRL 4 with a patent pending and is applicable to various markets including battery manufacturing, solar energy, and semiconductor fabrication. This opportunity is available for exclusive or non-exclusive licensing to existing companies or startups. Interested parties should contact the licensing department at Los Alamos National Laboratory by the response deadline of December 11, 2026.

Analytical Laboratory Instrument Manufacturing

POSTED

DEADLINE

TIDAL: Target-Induced Droplet Assembly of Ligands

Solicitation # S-197478

Developed by Los Alamos National Laboratory, TIDAL (Target-Induced Droplet Assembly of Ligands) is a programmable protein-only material that utilizes nanobodies fused with encapsulation peptides to create dynamic, liquid-like droplets through phase separation. This technology allows for the precise concentration of binders upon encountering a target ligand, enabling a versatile platform for resin-free protein purification, high-sensitivity diagnostics, and the creation of slow-release drug depots. It can also function intracellularly to sequester and neutralize harmful proteins associated with viral infections or cancer. The technology is currently at TRL 3 with a patent pending and is available for exclusive or non-exclusive licensing through the Department of Energy contractor, Triad. Key market applications span biopharmaceutical manufacturing, therapeutics, and biotechnology. Interested parties can contact Caleb Ledgerwood or Lindsay Augustyn via the provided licensing email to explore commercial partnerships for this innovation.

Research and Development in Biotechnology (except Nanobiotechnology)

POSTED

DEADLINE

TECHNOLOGY LICENSING OPPORTUNITY: AmineBind ML

Solicitation # S-196258

AmineBind ML is a descriptor-based software and machine learning surrogate model developed by Los Alamos National Laboratory to accelerate the discovery of amine-based carbon capture materials. By utilizing SMILES strings as molecular inputs, the Python-based toolkit predicts CO2 binding energies far more rapidly than traditional density functional theory. The model was trained on approximately 20,000 electronic-structure calculations, allowing researchers to screen millions of candidate chemistries in minutes to identify materials that optimize the balance between CO2 uptake and regeneration temperatures. This technology is particularly applicable to direct air capture, specialty chemicals, and computational chemistry, offering a streamlined pipeline that integrates atomic-scale predictions with mesoscale modeling. Currently at TRL 3 with a patent pending, the software is available for exclusive or non-exclusive licensing through Los Alamos National Laboratory to support the development of high-performance sorbents and the reduction of trial-and-error in laboratory campaigns.

Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

POSTED

DEADLINE

Software Integration & Tool Development (T5032)The Software Integration and Tool Development subcontract under T5032 supports the Department of Energy by developing and maintaining software infrastructure for the SCACS toolkit. The project focuses on software engineering to create APIs for material design engineers and the integration of the Simulator Collection into functional software packages. Technical execution involves the use of Git version control and CI/CD pipelines to ensure the delivery of a deployable software toolkit. This opportunity is managed by Triad, a DOE contractor, with performance taking place in Los Alamos, New Mexico. The contract falls under NAICS code 541511 and was posted on August 18, 2026, with a response deadline of February 16, 2027.

Custom Computer Programming Services

POSTED

about 1 month ago

DEADLINE

Multiscale Physics Simulation EngineeringThe Multiscale Physics Simulation Engineering subcontract, managed by Triad for the Department of Energy, focuses on integrating high-fidelity atomic physics models into engineering-scale finite element workflows for DOE technology licensees. By embedding machine-learned physics into finite element analysis, the project bridges the gap between atomic-scale simulations and continuum-scale engineering tools to produce a functional multiscale simulation workflow capable of outputting critical hot-spot and current-steering data. This technical effort requires the use of specific FEA software and multiscale modeling toolkits to achieve its objectives. The project is based in Los Alamos, New Mexico, and falls under NAICS code 541330. The response deadline for this opportunity is February 16, 2027.

Engineering Services

POSTED

about 1 month ago

DEADLINE

AI/ML Model Development (Graph Neural Networks)This subcontract, managed by Triad for the Department of Energy, focuses on the acceleration and optimization of the SCACS platform for DOE technology licensees. The project involves implementing Graph Neural Networks to speed up atomic-site-projected conductivity methods, utilizing million-atom microstructure datasets to train models and optimizing AI inference for physics-grounded predictions. The final deliverable is an optimized and accelerated AI simulation engine. The work will be performed in Los Alamos, New Mexico, and requires the use of High-Performance Computing clusters and GPU acceleration frameworks. The opportunity was posted on August 18, 2026, with a response deadline of February 16, 2027, falling under NAICS code 541511.

Custom Computer Programming Services

POSTED

about 1 month ago

DEADLINE

Simulator Collection for Atomic to Continuum Scales (SCACS)

Solicitation # S-196281

The Simulator Collection for Atomic to Continuum Scales (SCACS), identified by solicitation number S-196281, is an AI-driven multiscale simulation platform developed by Los Alamos National Laboratory to predict spatially varying, direction-dependent thermal and electrical transport in systems of up to one million atoms. By utilizing proprietary Site-Projected Thermal Conductivity (SPTC-AI) and Site-Projected Electronic Conductivity (SPEC-AI) modules, the toolkit bridges the gap between high-fidelity atomistic physics and continuum-scale engineering models. The system employs graph neural networks and FEniCSx-based solver modules, such as sptc2fem and spec2fem, to generate precise temperature and current maps while maintaining atomic-scale anisotropy. This allows engineers to identify localized hot-spots and transport pathways that are typically missed by conventional continuum models, reducing simulation runtimes from days to minutes. Currently at Technology Readiness Level 4 with a pending U.S. patent and associated software T5032, SCACS is offered as a licensing opportunity through the Richard P. Feynman Center for Innovation. The technology is designed for seamless integration with industry-standard finite-element solvers like Abaqus and has broad commercial applications in semiconductor advanced packaging, fusion energy systems, aerospace, battery thermal management, and quantum device manufacturing. The opportunity is managed by the Department of Energy via Triad, with a response deadline of February 16, 2027.

Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

POSTED

about 1 month ago

DEADLINE

TECHNOLOGY LICENSING OPPORTUNITY: SiloGetter

Solicitation # S-167718

SiloGetter is a technology developed by Los Alamos National Laboratory featuring a 3D-printable siloxane composite designed to capture hydrogen in sealed electronics, vacuum instruments, and metal containers. The material utilizes a palladium-on-carbon catalyst and DEB embedded in a gas-permeable siloxane polymer to absorb over 80 percent of encountered hydrogen. This innovation allows for the creation of custom, high-surface-area shapes via direct ink writing using nozzles as fine as 400 microns, providing a durable alternative to brittle pellets or loose powders. The composite is significantly more efficient than previous versions, carrying roughly 50 percent getter by weight, which is nearly ten times the capacity of earlier materials. It remains chemically stable at temperatures up to 75 degrees Celsius, ensuring mechanical integrity and high absorption efficiency. This technology is particularly applicable for microelectronics packaging, aerospace components, and ultrahigh vacuum scientific instrumentation. The opportunity is currently at TRL 4 with a pending U.S. patent and is available for exclusive or non-exclusive licensing.

All Other Plastics Product Manufacturing

POSTED

about 1 month ago

DEADLINE

Hydrogen-Safe System Integration

Printed Circuit Assembly (Electronic Assembly) Manufacturing

POSTED

about 1 month ago

DEADLINE

in about 2 months

Ready to Pursue This Opportunity?

Get AI-powered intelligence on this solicitation and the ones like it

Every page of the solicitation package shredded into a compliance breakdown

AI-powered matching based on your capabilities and past performance

Competitor and incumbent history on the requirement

Automated alerts on amendments, Q&A deadlines, and award

Join 750+ contractors already using CLEATUS