Solid Phase Peptide Synthesis (SPPS) – Cyclic Peptide Manufacturing

The contract entails the full solid-phase peptide synthesis of the cyclic peptide NPC86 using Rink amide resin, encompassing all steps from synthesis through cleavage, purification, and final lyophilization to deliver a minimum of 2 grams of product with a purity threshold of at least 95% as determined by HPLC, though the method is not validated. The work is to be executed under subcontract specifications, with the manufacturing process adhering to standard SPPS protocols for cyclic peptides, including proper side-chain protection, coupling efficiency, cyclization, and purification techniques to isolate the target molecule. The final deliverable must meet strict purity requirements, with all analytical data provided to confirm compliance. The solicitation was posted on July 23, 2026, with a response deadline of July 28, 2026, and is administered by the Department of Veterans Affairs through the 248-NETWORK Contract Office 8. The NAICS code 325412 indicates the work falls under pharmaceutical and biological product manufacturing, aligning with the technical scope of peptide synthesis and purification. The place of performance and point of contact details are not specified, and the contract opportunity is publicly accessible via the SAM.gov portal, leaving potential offerors to confirm logistical and procedural details directly through the provided UI link.