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POTOMAC AFFINITY PROTEINS, LLC

UEI: MD3PXLK9TCM6CAGE: 4GM56

POTOMAC AFFINITY PROTEINS, LLC is a federal contractor, registered under UEI MD3PXLK9TCM6 and CAGE code 4GM56. It has been awarded $8,643,338 in federal contracts. Primary work spans Unknown NAICS and Research and Development in Biotechnology (except Nanobiotechnology). Top awarding agencies include Department Of Health And Human Services, Department Of Defense, and Department Of Commerce (doc).

Contact Information

Registration and classification details

Websitehttps://www.potomac-affinity-proteins.com

Address123 Main St, City, ST 12345

Registration

UEI Code

MD3PXLK9TCM6

CAGE Code

4GM56

Entity Structure

Corporate Entity (Not Tax Exempt)

Established

N/A

Business Classifications

For Profit OrganizationSubchapter S Corporation

NAICS Codes

541714Research and Development in Biotechnology (except Nanobiotechnology)(Primary)

Federal Contracting Overview

Award totals, agency breakdown, NAICS distribution, and geographic footprint.

AI Capability Profile

POTOMAC AFFINITY PROTEINS, LLC specializes in advanced life sciences research and development services, with a primary focus on protein biochemistry and molecular analytics under NAICS 541714. The firm delivers specialized technical support in protein expression, purification, characterization, and ...

Key Performance Metrics

Awards Count

15

All time

Active

3

Currently performing

Completed

12

Past period of performance

Total Awards

All time

Contracts

Prime · all time

Subcontracts

Sub · all time

Grants

Prime · all time

Subgrants

Sub · all time

Award Analytics & Distribution

Awards by Agency

Department Of Health And Human Services$7.6M87.8%Department Of Defense$725.8K8.4%Department Of Commerce (doc)$215.0K2.5%

$110.0K1.3%

Awards by NAICS

- Unknown NAICS$8.4M97.5%

541714 - Research and Development in Biotechnology (except Nanobiotechnology)$220.0K2.6%

Awards by Agency Over Time

Awards by Place of Performance

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PEO-M Undersea Test Shape and Cradle Assessment Event (AE)

Solicitation # PEO_M_Undersea_Test__Shape_and_Cradle_AE

Department Of Defense

POSTED

about 14 hours ago

DEADLINE

Area of Interest (AoI) – Metal Cleaning and Finishing Services

Solicitation # W911KF25SC002-AoI0016

The Army Contracting Command Anniston Army Depot is seeking innovative commercial solutions for depot-level metal cleaning, surface preparation, and finishing services for combat vehicle components. This requirement, issued under solicitation W911KF25SC002-AoI0016, encompasses chemical stripping, alkaline immersion cleaning, and abrasive media cleaning to remove paint, corrosion, scale, and carbon. The scope includes a wide array of plating and coating processes such as anodizing, chromate conversion, black oxide, electroless nickel, hard chrome, zinc, tin, copper, and phosphate. The government anticipates utilizing a Multiple Award Task Order Contract structure to ensure technical redundancy and coverage. Key performance requirements include a strict seven-working-day turnaround time and the contractor's responsibility for the secure pick-up and delivery of parts to and from the depot in Alabama. Offerors must demonstrate significant facility capabilities, including specific tank and oven dimensions, crane clearances, and the capacity to handle high-volume part streams of varying sizes. A rigorous quality assurance approach is mandatory, requiring the ability to perform various ASTM and MIL-SPEC tests, such as salt spray, adhesion, and hydrogen embrittlement, either in-house or through certified laboratories. Evaluation will be based on technical feasibility, the safety and efficiency of cleaning methods, innovation in eco-friendly processing, and the robustness of quality control systems. Additionally, the government will assess the offeror's track record with hazardous material management and compliance with environmental regulations. Interested parties must submit a written Solution Brief by October 28, 2026, including a Rough Order of Magnitude or unit pricing structure for evaluation.

Department Of Defense

POSTED

about 14 hours ago

DEADLINE

MPS Platform Development & EngineeringThis subcontract focuses on the development and engineering of Microphysiological Systems and Organ-on-a-Chip platforms to support prime contractors on NIH/NIAID infectious disease projects. The scope of work involves engineering microfluidic devices, optimizing tissue-chip interfaces, and utilizing biocompatible polymers and precision pumps to integrate human variability into hardware and biological interfaces. The ultimate goal is to deliver a validated and reproducible platform that aligns with NIH and FDA guidance regarding New Approach Methodologies. Managed under the National Institutes of Health within the Department of Health and Human Services, the project falls under NAICS code 541714. The solicitation was posted on October 20, 2026, with a response deadline set for January 29, 2027.

National Institutes Of Health

POSTED

about 22 hours ago

DEADLINE

Translational Centers Using Microphysiological Systems for Infectious Diseases (U54 Clinical Trial Not Allowed)

Solicitation # RFA-AI-28-012

The National Institute of Allergy and Infectious Diseases (NIAID) has issued solicitation RFA-AI-28-012 to establish a consortium of Translational Centers Using Microphysiological Systems for Infectious Diseases (TCMID). The primary objective is to refine and validate human tissue models using Microphysiological Systems (MPS) to a level consistent with regulatory qualifications, thereby promoting their adoption by product developers and reducing reliance on laboratory animals. This initiative aligns with NIH and FDA guidance on New Approach Methodologies (NAMs) to accelerate the development of safer medical interventions by capturing human variability and patient-specific characteristics. The program is structured around an Administrative Core, a Qualification Core, and Scientific Cores, with a heavy emphasis on technical readiness, reproducibility, and regulatory acceptance. Key deliverables include the validation of assays for specific endpoints and the submission of regulatory packages. Applicants must be domestic entities, as foreign organizations and foreign subawards are strictly prohibited. Required personnel must possess deep expertise in infectious diseases, MPS platforms, bioinformatics, and FDA submission processes. Applications are due by January 29, 2027, and must be submitted via the NIH ASSIST system or approved institutional system-to-system solutions. Evaluation is based on an overall impact score considering the project's significance, the suitability of the investigators, and the quality of the institutional environment. Mandatory application components include a Data Management and Sharing Plan and a Benchmarks and Timeline PDF not exceeding six pages. Awardees must also adhere to strict cybersecurity incident reporting guidelines, notifying HHS within 48 hours of any discovery.

National Institutes Of Health

POSTED

about 22 hours ago

DEADLINE

Immune Tolerance Network (UM1 Clinical Trial Required)

Solicitation # RFA-AI-28-005

The National Institutes of Health, under the Department of Health and Human Services, is seeking applications through solicitation RFA-AI-28-005 to continue the Immune Tolerance Network (ITN). This cooperative agreement aims to develop tolerogenic therapies for immune-mediated disorders, specifically focusing on autoimmune diseases, allergic diseases and asthma, and the immune-mediated consequences of transplantation. The network operates through four integrated functional areas: Leadership, Clinical Operations, Core Laboratory, and Bioinformatics. Its primary objectives include designing and conducting clinical trials, performing integrated mechanistic studies, and sharing research results. Eligible applicants include small businesses and other for-profit organizations, though non-domestic entities are ineligible. Applications are evaluated based on scientific and technical merit, with a primary focus on significance and the likelihood of exerting a sustained influence on the research field. Key requirements include maintaining active registrations in SAM.gov, eRA Commons, and Grants.gov, as well as adhering to strict cybersecurity incident reporting and human subject protection protocols. The project requires a minimum effort of 3.6 person months per year for the PD/PI and mandates participation in a kick-off meeting in Bethesda, Maryland, and bi-annual steering meetings. Applications must follow specific page limits for the research strategy subsections and include detailed plans for clinical trial implementation, data management, and biorepository services.

National Institutes Of Health

POSTED

about 22 hours ago

DEADLINE

Army Contracting Command – Red River Army Depot (ACC-RRAD) Organic Industrial Base (OIB) Modernization Commercial Solutions Opening (CSO)

Solicitation # W911RQ-27-S-C001

The Army Contracting Command – Red River Army Depot (ACC-RRAD) has issued Commercial Solutions Opening (CSO) W911RQ-27-S-C001 to modernize its Organic Industrial Base (OIB). This initiative focuses on Convergent Manufacturing, seeking innovative commercial items, technologies, and services in areas such as digital twins, automation, cyber security, and agile facilities to enhance the Defense Manufacturing Base. The CSO utilizes a streamlined acquisition process authorized by DFARS Subpart 212-70, allowing both traditional and non-traditional defense contractors to compete for FAR Part 12 commercial item contracts. The overall solicitation remains open until September 30, 2027, with a general period of performance for awarded solutions typically not exceeding 12 months. The procurement is executed through specific Areas of Interest (AoIs), which have included requirements for micro trucks, industrial parts washer leasing and maintenance, and fire suppression system repairs for Building 431. The evaluation process is conducted in three phases: an initial solution brief, a presentation or pitch, and a final Commercial Solutions Proposal. Technical evaluations prioritize responsiveness to the AoI, technical merit, and innovation, while price proposals must be determined as fair and reasonable. Awardees must be registered in the System for Award Management (SAM) and possess a Unique Entity ID. Specific project requirements may include strict adherence to military marking standards, environmental liability insurance, and certification by registered professional engineers.

Department Of Defense

POSTED

DEADLINE

Pre-Clinical Models of Infectious Diseases

Solicitation # 75N93027R00003

The National Institute of Allergy and Infectious Diseases (NIAID) is issuing a ramp-on solicitation to award multiple IDIQ base contracts for the Preclinical Models of Infectious Diseases program. This initiative aims to expand the existing pool of contractors capable of developing and refining animal and animal replacement models to evaluate medical countermeasures, such as vaccines, therapeutics, and diagnostics. The program bridges the gap between in vitro testing and clinical evaluation, supporting regulatory submissions and the advancement of countermeasures against priority biodefense and emerging infectious agents. Successful offerors will be eligible to compete for task orders across four specific areas: Small Animal Models, Non-Human Primate Models, Animal Replacement and Non-traditional Animal Models, and the Generation and Distribution of Specialized Reagents. The scope of work emphasizes a wide array of pathogens, including pandemic-potential RNA viruses, antimicrobial-resistant infections, fungal diseases, and neglected tropical diseases. Proposals must be submitted electronically via the NIAID eCPS website, and applicants are required to have a valid NIH eRA Commons account for authentication and secure transmission.

National Institutes Of Health Niaid

POSTED

DEADLINE

in about 2 months

Alternative Protein Technologies for Military Field Feeding

Solicitation # W911QY27ALTPROTEINS

W6QK Acc-Apg Natick

POSTED

DEADLINE

in about 1 month

USDA SBIR/STTR Topic 8.2 — Plant Production and Protection - Biology

Solicitation # USDA-NIFA-TOPIC-8.2

The USDA National Institute of Food and Agriculture is soliciting proposals under Topic 8.2 for Plant Production and Protection - Biology. This initiative focuses on advancing crop production and protection through the development of innovative plant breeding methods, diagnostic technologies for diseases, and the creation of new food and non-food crop plants. Research efforts are directed toward improving plant characteristics to mitigate biotic and abiotic stresses, developing new genotypes for commercial applications, and creating tools to support the health of natural and domesticated pollinators. This opportunity is a total small business set-aside under the SBIR/STTR mandate, restricting eligibility to companies with fewer than 500 employees. Managed by the United States Department of Agriculture, the program is led by Dr. Christopher Philips. Interested parties can find further details and application guidelines through the NIFA website.

National Institute of Food and Agriculture

POSTED

DEADLINE

Artificial Blood and Medical Consumable InnovationThe Artificial Blood and Medical Consumable Innovation subcontract supports the Defense Advanced Research Projects Agency within the Department of Defense. The scope of work involves providing innovative medical consumables and conducting biochemical research specifically focused on the development of artificial blood for prime contractors on DARPA Biological Technologies Office projects. The contractor is responsible for engineering scalable manufacturing processes for these consumables using sterile manufacturing facilities and bio-reactors. Key deliverables include the production of artificial blood prototypes and the implementation of scalable medical consumable solutions. This effort falls under NAICS code 541714, with a response deadline set for November 15, 2026.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

Pre-Award Synopsis Texas Shield

Solicitation # DARPA-SN-27-07

The Defense Advanced Research Projects Agency (DARPA), through its Biological Technologies Office (BTO), intends to enter into an agreement with The University of Texas System consortium of universities for the Texas Shield Program. This integrated research initiative, identified by solicitation number DARPA-SN-27-07 and NAICS code 541714, focuses on developing autonomous and semi-autonomous medical technologies and scalable solutions for critical medical consumables. The primary goal is to support lifesaving medical care in contested, austere, and resource-limited environments. Key technical areas of focus include autonomous medical and robotic surgical systems, casualty evacuation, artificial-blood and supply innovation, AI-enabled clinical decision support, and mass-casualty science and simulation. This notice is a pre-award synopsis and is not a request for proposals or a competitive solicitation. Interested entities are invited to submit information by November 15, 2026, to TexasShieldxBTO@darpa.mil detailing their technical expertise, integrated research infrastructure, clinical-validation capabilities, and multi-institutional coordination capacity. Additionally, respondents must describe their consortium organizational structure, commercialization capabilities, facility clearance levels, and their ability to handle Controlled Unclassified Information. The government will not reimburse any costs associated with the preparation or submission of information in response to this notice.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

Q--AMPLICON SEQUENCING SERVICES

Solicitation # 140G0226Q0047

Solicitation 140G0226Q0047 is a firm-fixed-price request for a Blanket Purchase Agreement (BPA) to provide next generation amplicon sequencing services for the USGS Upper Midwest Water Science Center’s Michigan Bacteriological Research Laboratory. The scope of work includes providing all equipment, labor, travel, and materials necessary to support research on bacterial pathogens, harmful algal blooms, microbial ecology, antibiotic resistance, and microbial source tracking. Key technical requirements include the use of Illumina MiSeq or AVITI sequencing technologies and the potential for library preparation for 16S V4 amplicon sequencing. The BPA has a total not-to-exceed value of 250,000 dollars with an estimated period of performance from September 17, 2026, to September 16, 2031. The award process prioritizes non-priced factors significantly over cost, focusing on the offeror's qualifications and technical performance. Evaluation criteria include a detailed listing of on-site equipment and calibration dates, personnel experience, internal quality assurance procedures, and a technical narrative not exceeding two pages. Performance will be executed in Lansing, Michigan, with delivery terms set as FOB Destination. Administrative requirements include electronic invoicing via the Internet Payment Platform and compliance with various federal regulations, including the Buy American Act and specific security prohibitions regarding telecommunications equipment. Proposals must be submitted to the USGS OAG Denver Acquisition Branch by September 11, 2026.

Ofc Of Acquisition Grants-Denver

POSTED

DEADLINE

USSPACECOM Command and Control Facility (C2F): Design-Build Contractor (DBC) for Collaborative Delivery

Solicitation # c3df0d41-753d-4399-a6e3-12b580d1bfa2

The United States Space Command is seeking a qualified Design-Build Contractor to develop an approximately 800,000 gross-square-foot Command and Control Facility at Redstone Arsenal, Alabama. Utilizing a Progressive Design-Build approach, the selected partner will be responsible for the comprehensive design and construction of a mission-ready warfighting platform. The scope of work encompasses secure facility infrastructure, C4IT integration, fixtures, furniture and equipment, commissioning, and final accreditation. This project aims to accelerate traditional military construction timelines by integrating complex security requirements and technical performance standards through a collaborative delivery model. The government requires a partner with multidisciplinary expertise capable of managing high technical complexity, risk, and cost while ensuring the facility is resilient and fully operational. Interested parties must submit their responses by December 3, 2026.

Department Of Defense

POSTED

DEADLINE

in about 1 month

RFI Lupus Research Program (LRP) Public

Solicitation # HT9427RFI2027LRP

The Defense Health Agency, through the Congressionally Directed Medical Research Programs, has issued a Request for Information regarding the Lupus Research Program for fiscal year 2027. This action is strictly for information and planning purposes to identify future research focus areas and funding opportunities; it is not a solicitation, and no contracts will be awarded based on this announcement. The program aims to cure lupus by funding research to improve diagnosis, prevention, and treatment, with a specific focus on understanding biological or genetic patient subsets, disease mechanisms, and enhancing overall patient quality of life. Interested parties from academia, industry, non-profit organizations, and the public are invited to provide feedback on critical research gaps and underfunded areas. Responses must be submitted via Survey Monkey by November 16, 2026. While historical appropriations from fiscal years 2017 through 2024 and 2026 totaled 75 million dollars, funds for fiscal year 2027 have not yet been appropriated. Respondents are cautioned not to submit proprietary or sensitive information through the survey portal, as the government cannot protect such data, and all costs associated with responding to this request are the responsibility of the participant.

Defense Health Agency

POSTED

DEADLINE

Solicitation # W91QV127RA006

The Department of Defense, specifically the Office of Army Cemeteries and Army National Military Cemeteries, is seeking a small business contractor to provide professional soft skills training for approximately 250 civilian and military personnel. This effort, classified under NAICS 611430, involves a fixed-fee contract to deliver six specific training courses via MS Teams between December 2, 2026, and September 7, 2027. The curriculum includes sessions on the 10 essential soft skills, civility in the workplace and conflict resolution, emotional intelligence, goal setting, managing workplace anxiety, and handling difficult people and conversations. While the government initially intended to award a sole source contract to DrTinaTalksWork, the identification of multiple capable vendors has shifted the action toward a 100 percent small business set-aside competitive action. To be considered, vendors must demonstrate specific qualifications, including a Doctorate in Management and Organizational Leadership or equivalent, prior Department of Defense affiliation, and accreditation through the International Accreditors for Continuing Education and Training. Interested small businesses were required to submit a capability statement of no more than five pages by October 24, 2026.

Department Of Defense

POSTED

DEADLINE

AIR FORCE CRYPTOLOGIC OFFICE COMMERCIAL SOLUTIONS OPENING

Solicitation # FA7037-21-S-C001

The Air Force Cryptologic Office Cyberspace Intelligence Surveillance and Reconnaissance and Multi-Domain Innovation Division is soliciting innovative commercial capabilities through Commercial Solutions Opening FA7037-21-S-C001. The agency is seeking mature technologies and services in Electromagnetic Warfare, Information Operations, and electromagnetic digital communications, with a specific goal of achieving a field demonstration within one year. This effort emphasizes the use of novel material approaches and innovative services, including a recent update to incorporate Super Intelligence. Awards may be issued as contracts or Other Transactions with periods of performance typically ranging from one to five years. The procurement follows a competitive two-phase submission process governed by 10 USC 3458 and DFARS 212.70. Phase I requires the submission of Quad Charts and White Papers, which are evaluated based on technical merit, importance to the AFCO mission, and fund availability. Offerors who are determined to be technically qualified may be invited to submit full Phase II proposals, including a detailed Statement of Work and a price proposal. All submissions are treated as commercial items, and offerors must possess the necessary personnel and facility security clearances to handle classified work in accordance with the National Industrial Security Program Operating Manual.

Department Of Defense

POSTED

DEADLINE

Clinical Trial Site Operations and Participant ManagementThis subcontract for Clinical Trial Site Operations and Participant Management supports prime contractors on NIH/NIDDK projects through the direct execution of clinical trials. The scope of work includes recruiting and enrolling study participants, implementing lifestyle intervention weight loss programs, and conducting scheduled study visits and clinical procedures. To ensure compliance and quality, the provider must maintain IRB approval, active SAM/eRA Commons registration, and utilize specialized clinical trial facilities equipped with medical-grade ultra-low temperature freezers for biospecimen storage. The primary deliverables for this engagement consist of completed participant visits, curated patient data, and the collection of biospecimens. This opportunity is associated with NAICS code 541714 and falls under the jurisdiction of the National Institutes of Health within the Department of Health and Human Services. The response deadline for this requirement is November 17, 2026.

National Institutes Of Health

POSTED

DEADLINE

replacement skidsteerutility vehicle and attachmentsThe US Geological Survey, under the Department of the Interior, is forecasting the acquisition of a replacement skidsteer utility vehicle and associated attachments. This procurement is intended to support the National Wildlife Health Center located in Madison, Wisconsin, specifically benefiting the Midcontinent Region and Ecosystems Mission Area. The project is categorized under NAICS code 541714 and is listed as a forecast with a posted date of October 14, 2026. Sean Jones serves as the primary point of contact and small business specialist for this requirement.

US Geological Survey

POSTED

DEADLINE