99 -- NOI7132

This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR Part 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are not being requested and a written solicitation will not be issued. The solicitation number for this acquisition is NOI7132 AND THE SOLICITATION IS BEING ISSUED AS A NOTICE OF INTENT. This NOI is not a small business set aside. This solicitation document and its incorporated provisions are those in effect through the Federal Acquisition circular (FAC 2005-18). This acquisition will be processed under Simplified Acquisition Procedures. The associated North American Industry Classification System (NAICS) Code for this acquisition is 519190 and the small-business size is $6.5. The National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID) acquire a Conditional Knock out/in Mouse using the Artemice/Taconic platform. This contract is to generate a Conditional Knock In Mouse using the Artemice platform. The vendor must have a proven record of success with conditionalgene targeting technologies and provide the Cre-lox, CreER, and FLP-FRT systems to allow for further temporal or tissue specific gene modifications in vivo. The vendor must create the targeting vector incorporating these conditional knockout systems to the investigator?s specifications and transfect the vector into C57BL6 ES cells. Isolated targeted clones must be validated with both internal and external probes, and a minimum of 2 clones must be injected into diploid blastocysts. Chimeras must be crossbred to generate heterozygous conditional knockout mice and the selection marker must be deleted in vivo with the FLP-FRT system. The mouse model must be fully licensed to customer with positive/negative selection (PNS) and isogenic DNA patents. The expected time line for generation of heterozygous mice should be 46 weeks. This notice of intent is not a request for competitive proposals. Interested parties may identify their interest and capabilities in response to this requirement. The following FAR provisions and clauses apply to this acquisition: FAR 52.212-1 Instructions to offerors Commercial Items; FAR 52.212-2 Evaluation ? Commercial Item; FAR 52.212.3 offerors Representations and Certifications Commercial Items; FAR 52.212-4 Contractor Terms and Conditions Commercial Items; FAR 52.212-5 Contract Terms and Conditions Required to Implement Statutes or Executive Orders Commercial Items; and FAR 52.204-7 Central Contractor Registration (CCR). In order to be considered for an award, offeror must have completed the online electronic Representatives and Certifications located at (http://orca.bpn.gov/) in accordance with FAR 4.1201(a). By submission of an offer, the offeror acknowledges the requirement that a prospective awardee shall be registered in the CCR at (www.ccr.gov/) prior to award, during performance, and through final payment of any contract, basic agreement, basic ordering agreement, or blanket purchasing agreement resulting from this solicitation. Offers must be submitted no later than 5:00 P.M. Eastern Daylight Time (EDT), September 22, 2007 to Ms. Iris Johnson. Copies of the aforementioned clauses are available upon request by telephone to Ms. Iris Johnson at (301) 402-6684. For deliver through the Postal Service, the address is NIH/NIAID/AMOB, 10401 Fernwood Drive, Room 2NE70F, Bethesda MD 20892-4811. Electronic transmissions will not be accepted. Requests for information concerning this requirement are to be addressed to Ms. Iris Johnson. Collect calls will not be accepted. All responsible sources may submit an offer that will be considered by this agency.