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A--Roche - Seqcap EZ Human Exome Library 2.0

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VA24112P1297Federal

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

AI Contract Overview

The Department of Veterans Affairs Network Contracting Office 1 (NCO 1 New England) intends to award a sole-source, firm-fixed-price purchase order to Roche Diagnostics Corporation for specialized genomic sequencing supplies essential to a VA Connecticut HealthCare System research study. This study, part of the Cooperative Studies Program (CSP) #572, focuses on the genetics of functional disability in schizophrenia and bipolar illness. Specifically, the contract will supply Roche SeqCap EZ Human Exome Library v2.0 reagents and associated hybridization and washing kits, which are unique products available only from Roche, to support exome sequencing analysis on samples from enrolled veterans. The award, valued at approximately $158,000, supports sub-study analyses aimed at identifying genetic risk factors linked to psychiatric disorders and associated clinical phenotypes such as cognitive impairment and suicidality among veterans. The research involves a genome-wide association study comparing large cohorts of veterans with schizophrenia, bipolar illness, and healthy controls, with a sub-study processing 600 samples using advanced genotyping and exome sequencing technologies exclusively provided by Roche. The sole-source award justification aligns with federal acquisition regulations that permit non-competitive procurements when only one responsible source exists. Contract administration details, including contact information for the Contract Specialist, are provided, with encouragement for qualified veteran-owned and service-disabled veteran-owned small businesses to register with relevant federal systems to support future contracting opportunities. This action is a notice of intent to award and not a solicitation, reinforcing that no other vendors can meet the specialized technical requirements for this study.

General Info

Sole-source $158K contract to Roche for specialized genomic sequencing in veteran psychiatric disorder research.

Agency

Department Of Veterans Affairs → 241-NETWORK Contract Office 01 (36C241)

NAICS

541711 - Research and Development in Biotechnology

Place of Performance

Set-Aside

NONE

Documents

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Timeline

PhaseSources Sought

PostedSep 18

Sources Sought

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Organization & Contact Information

AgencyDepartment Of Veterans Affairs → 241-NETWORK Contract Office 01 (36C241)

ContactsNo contacts available

OfficeTOGUS, ME, 04330, USA

Organization / AgencyDepartment Of Veterans Affairs → 241-NETWORK Contract Office 01 (36C241)

Office AddressTOGUS, ME, 04330, USA

ContactsNo contact information available

Full Description

Notice of Contract Action (NOCA), notice of intent to award sole source contract. This is not a solicitation. The Department of Veterans Affairs Network Contracting Office 1 (NCO 1 New England) 90C/650/241 intends to negotiate and award a purchase order to ROCHE DIAGNOSTICS CORPORATION, 9115 Hague Road, Indianapolis, IN 46256-1025. (DUNS: 001824663.) VA Connecticut HealthCare System and the Clinical Epidemiology Research Center (CERC) is conducting a Central Institutional Review Board (CIRB) approved research study: Cooperative Studies Program (CSP) # 572, Genetics of Functional Disability in Schizophrenia and Bipolar Illness. Under the CSP#572 sub-study entitled, Preliminary Genome Analyses: Genotyping and Exome Sequencing VA is conducting Exome sequencing analysis on the enrolled and consented research population as funded in requisition number 689-12-3-2115-0128. The equipment/services are described as follows: The proposed action is a sole-source award of a Firm-Fixed Price (FFP) supply contract for the purpose of purchasing Roche SeqCap EZ Human Exome Library v2.0 and SEQCAP EZ HYB and Wash as required for Exome sequencing analysis under CSP#572 sub-study, Preliminary Genome Analyses: Genotyping and Exome Sequencing. The proposed awardee is ROCHE DIAGNOSTICS CORPORATION, 9115 Hague Road, Indianapolis, IN 46256-1025. (DUNS: 001824663.) Roche is the sole manufacturer of the Roche SeqCap EZ Human Exome Library v2.0, Roche is the only qualified vendor for this specific product as specified in the protocol. Purchase Roche SeqCap EZ Exome Library v2.0, 48 reactions (#05860504001) and 7 SEQCAP EZ HYB AND WASH, 96 RXN (#05634253001). The estimated dollar value is $158,000.00. The study (CSP# 572) purpose is to conduct a genomewide association analysis, comparing 9,000 veterans with schizophrenia and 9,000 veterans with bipolar illness to approximately 20,000 "psychiatrically healthy" veterans, thereby investigating genetic risk factors for these disorders. The VA Investigators, Philip Harvey (Miami VA); Larry Siever (Bronx VA); John Concato (CT VA); Michael Gaziano (Boston VA) and under approved VA Institutional Review Board ( VA Central IRB # 09-17) require the supplies in furtherance of the captioned sub-study. The second primary aim is to determine genetic risk factors underlying several phenotypes reflecting important clinical outcomes among patients with schizophrenia (SZ) and bipolar illness (BP)-including functional disability, cognitive impairment, suicidality, and tardive dyskinesia-and to determine whether/how they overlap with the susceptibility genes for the disorders themselves. As a sub-study of this project, VA is to conduct genotyping with exome chip processing of 600 samples (200 SZ, 200 BP and 200 controls) using 2.5M array and exome chips, followed by running Sequence Capture of the samples using Roche SeqCap EZ Human Exome Library v2.0, using oligo pool SeqCap EZ Hyb and Wash to complete the processing of the samples. The authority for this action is 41 USC §253(c)(1), as implemented by FAR 6.302-1, Only one Responsible Source and no other supplies or services will satisfy agency requirements. This notice contains information current through FAC 2005-61. The NAICS is 541711 The FSC/PSC is 6550 No solicitation will be posted to this site. Interested persons may contact the Contract Specialist regarding this procurement and may identify capabilities for items of this kind. Contract Specialist: John Young, +1 (555) 000-0000 x 1588, contact@example.gov. A decision not to compete this requirement is based upon this notice and the Justification and Approval (J&A) to be posted to this site. Service Disabled and Veteran-Owned Small Businesses (SDVOSB and VOSB) contracting with VA are be registered and certified by the Center for Veteran Enterprise (CVE) in VetBiz if seeking consideration under PL 109-461 (www.vetbiz.gov - Vendor Information Pages - VIP) All contractors are required to be registered in the System for Award Management (www.sam.gov). Consult your State Procurement Technical Assistance Center (PTAC) for technical assistance with these requirements. (http://www.dla.mil/db/procurem.htm).