This Special Notice opportunity from Department Of Health And Human Services was posted on February 6, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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Agentic AI-EnableD CardioVascular CAre TransfOrmation (ADVOCATE) Question and Answer Webinar Special Notice

Closed

ARPA-H-SN-26-148Federal

Submission Closed02/10/2026, 05:00:00 PM EST

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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NAICS: 541714

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The Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office is hosting a virtual Industry Day on December 9, 2026, for the Laguna program under Special Notice DARPA-SN-27-18. The program's primary objective is to develop and demonstrate integrated manufacturing approaches that convert abundant domestic feedstocks, such as sugars, ethylene, and BTX, into application-ready specialty chemical formulations. By minimizing intermediate processing steps and separations, the initiative seeks to reduce reliance on vulnerable foreign supply chains. The anticipated 36-month effort is divided into two technical areas: Make and Formulate, which focuses on developing defense-relevant specialty products from U.S. raw materials, and Model, which aims to create predictive tools to optimize the relationship between feedstocks, synthesis, and final product performance. This notice is issued for information and program planning purposes and does not constitute a formal solicitation for proposals. Interested parties must register for the Industry Day event by December 2, 2026. The program requires that resulting products meet or exceed the performance of current military materials, with deliverables including technoeconomic analyses, life cycle assessments, and commercialization strategy plans. Technical and administrative inquiries are managed by Dr. William Mounfield and can be directed to [email hidden]. A draft program solicitation is expected to be released on sam.gov prior to the Industry Day event.

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Drug Development Infrastructure Supporting the Research Community in Medication Repurposing for Substance Use DisordersThe National Institutes of Health, through the National Institute on Drug Abuse, is forecasting a grant opportunity to establish a drug-development infrastructure aimed at accelerating the repurposing and repositioning of medications for substance use disorders. This initiative will provide academic and biotech investigators with essential scientific expertise and shared resources, spanning the entire development continuum from in silico discovery and preclinical validation to regulatory guidance and market-access planning. The infrastructure is designed to support user-led projects through a structured selection process and community outreach to move promising therapeutics toward clinical application. The program has a total estimated funding amount of 2,500,000 dollars with one expected award. The project is estimated to begin on April 1, 2028, and does not require cost sharing. Interested parties can coordinate with the NIDA OTIPI Program Staff regarding this effort to advance treatment options for various substance use disorder indications.

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Pre-solicitation Notice: On-Ramp for the Department of Defense OMNIBUS IV Multiple-Award Contract

Solicitation # HT942627RE002

The Defense Health Agency Contracting Activity intends to issue a Request for Proposal in early November 2026 for an on-ramp to the OMNIBUS IV Multiple Award, Indefinite Delivery, Indefinite Quantity contract vehicle. This opportunity is specifically set aside for small businesses certified under the Small Business Administration 8(a) Program and will focus on providing military medical research and development services. Multiple new awards are expected, all of which will align with the existing unrestricted contract vehicle. The OMNIBUS IV vehicle operates with a cumulative ceiling of 10 billion dollars and a performance period extending through June 19, 2032, including option years. To date, the contract has seen over 690 million dollars awarded across 61 task orders to various end users, including the Naval Supply Systems Command and the Uniformed Services University of the Health Sciences. Task orders may be competed via fair opportunity or through specific exceptions such as small business set-asides.

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Solicitation # USDA-NIFA-TOPIC-8.2

The USDA National Institute of Food and Agriculture is soliciting proposals under Topic 8.2 for Plant Production and Protection - Biology. This initiative focuses on advancing crop production and protection through the development of innovative plant breeding methods, diagnostic technologies for diseases, and the creation of new food and non-food crop plants. Research efforts are directed toward improving plant characteristics to mitigate biotic and abiotic stresses, developing new genotypes for commercial applications, and creating tools to support the health of natural and domesticated pollinators. This opportunity is a total small business set-aside under the SBIR/STTR mandate, restricting eligibility to companies with fewer than 500 employees. Managed by the United States Department of Agriculture, the program is led by Dr. Christopher Philips. Interested parties can find further details and application guidelines through the NIFA website.

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POSTED

DEADLINE

Solicitation # DARPA-PS-26-137

The Firefox program, managed by the DARPA Biological Technologies Office, is a 36-month, three-phase initiative seeking to develop a 100-channel, non-invasive brain-computer interface with 50-micron spatial and 100-microsecond temporal resolution. The program focuses on two primary technical hurdles: the creation of components for dynamic rastering and scanning of coherent optical signals to target multiple regions of interest, and the development of non-digital data processing architectures capable of handling high data rates and computational burdens. Multiple awards are anticipated, with funding ranging between 4 million and 7 million dollars per award. Awards will be issued as Other Transaction for Prototype agreements under 10 U.S.C. 4022, utilizing a milestone-based payment schedule. The selection process is multi-staged, beginning with an abstract evaluation based on technical comprehension, technical ability, and budget realism, followed by an Oral Presentation Proposal for selected candidates. Proposers must be registered in the System for Award Management and possess a Unique Entity Identifier. Key compliance requirements include adherence to ANSI laser safety limits for human tissue exposure, Cybersecurity Maturity Model Certification, and strict guidelines regarding organizational conflicts of interest and foreign influence risk assessments.

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POSTED

DEADLINE

Future Program: Laguna

Solicitation # DARPA-SN-27-15

Special Notice DARPA-SN-27-15, issued by the Defense Advanced Research Projects Agency Biological Technologies Office, serves as a public notification for the forthcoming Laguna program. This notice is intended for information and program planning purposes and does not constitute a formal solicitation for proposals. The program is anticipated to be a 36-month effort focused on the development and demonstration of defense-relevant specialty products formulated from U.S.-produced raw materials. These products must meet or exceed the critical performance requirements of existing military materials. Key deliverables for the program include predictive tools for material properties, life cycle assessments, technoeconomic analyses, and commercialization strategy plans. The primary point of contact for the initiative is Dr. William Mounfield. While this notice provides an overview of research interests, DARPA will not accept submissions at this time. Formal solicitation details and submission instructions will be posted on sam.gov upon release. All communications regarding this notice must remain unclassified.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

Leveraging NAMs to understand disease triggers, discover early biomarkers and develop new classes of therapeutic strategies for Type 1 Diabetes (U01 Clinical Trial Not Allowed)The National Institutes of Health is seeking research projects to investigate the initiation and early progression of Type 1 Diabetes using human-relevant New Approach Methodologies. Utilizing human cells, tissues, organoids, and microphysiological systems, the initiative aims to identify early biomarkers and therapeutic targets to prevent significant pancreatic beta cell loss. This effort focuses on combining innovative experimental and computational approaches to uncover the cellular and molecular mechanisms driving the disease. Selected awardees will join the Human Islet Research Network to foster collaboration, share data and tools, and coordinate the use of limited human pancreatic tissues. With total program funding of 12 million dollars and an expected 12 awards, the project is scheduled to begin around November 1, 2027. The overarching goal is to accelerate the translation of research discoveries into practical preventive and treatment strategies through a harmonized, multi-laboratory effort.

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Cooperative Agreement for affiliated Partner with Rocky Mountain Cooperative Ecosystem Studies Unit

Solicitation # G27AS00062

The U.S. Geological Survey is seeking a partner within the Rocky Mountain Cooperative Ecosystem Studies Unit to establish a cooperative agreement for research aimed at improving Chronic Wasting Disease surveillance. The project focuses on developing a robust, automated, and reproducible analytical pipeline to standardize Real-Time Quaking Induced Conversion assay data analysis, reducing the reliance on subjective interpretation. Key deliverables include the creation of machine-learning models using LSTM, CNN-LSTM, or hybrid architectures to classify fluorescence curves, the development of an open-source application via R-Shiny or Streamlit/Python for data ingestion and visualization, cross-laboratory validation across at least three independent facilities, and a peer-reviewed publication. The total program funding is estimated at 145,220 dollars for a single award, with an anticipated period of performance from April 1, 2027, to March 31, 2032. Applications must be submitted through grants.gov by December 8, 2026, and are evaluated based on purpose and relevance, technical approach, qualifications and past performance, and budget clarity. Recipients must comply with Department of the Interior general terms, geospatial data standards under the Geospatial Data Act of 2018, and federal regulations regarding financial reporting and conflict of interest. Required submission documents include a Project Abstract Summary, Biographical Sketches, and Current and Pending Support forms for all senior key personnel.

US Geological Survey

POSTED

9 days ago

DEADLINE

in 24 days

General Info

Agency

Department Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance

Washington, DC, 20005, USA

Set-Aside

NONE

Documents

special-notice

Low

AI Contract Breakdown

Uniform Contract Format

Timeline

PhaseClosed

PostedFeb 6

special-notice

Response DeadlineFeb 10

Deadline has passed

Submission Closed

02/10/2026, 05:00:00 PM EST

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)

Contacts1 person available

OfficeWashington, DC, 20005, USA

Organization / AgencyDepartment Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)

Office AddressWashington, DC, 20005, USA

Contacts

SEE DESCRIPTION SECTION

Full Description

This Special Notice (SN) is intended to alert the scientific community to an Advanced Research Projects Agency for Health (ARPA-H) Program and notify potential proposers of the ADVOCATE Question and Answer (Q&A) Webinar. The Scalable Solutions Office (SSO) is sponsoring a non-mandatory Q&A Webinar for the planned proposer community in support of the ADVOCATE program. This session is intended to provide additional clarification on the ADVOCATE Innovation Solutions Opening (ISO), ARPA-H-SOL-26 142, and to address questions that may have arisen following the Proposers’ Day held on January 23, 2026.

See attached SN ARPA-H-SN-26-148 for further details.