This Government Contract opportunity from Department Of Health And Human Services was posted on March 9, 2023. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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Analysis of 95 compounds in automated patch clamp assay to record sodium current using ND7/23 (LoNav) cells stably expressing human Nav1.7

Closed

75N95023Q00152Federal

Submission Closed03/17/2023, 04:00:00 PM UTC

Contract Overview

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NAICS: 541380

New

DIBBS

Product Verification Testing and Source Inspection for Critical LightingThis subcontract involves providing product verification testing and source inspection services for critical lighting items under the DLA Weapons Support Nuclear Reactor Program. The selected contractor will be responsible for conducting inspections and tests using sampling methods per MIL-STD-1916 or ASQ H1331, while ensuring that identification markings comply with MIL-STD-130N. Specialized equipment capable of verifying MIL-DTL-16377/8C and MIL-DTL-16377K SUP 1 is required to complete these tasks, with the final deliverables consisting of detailed inspection reports and test results. The project is categorized under NAICS code 541380 and will be performed in New Cumberland, Pennsylvania. Interested parties must respond by November 9, 2026, to support the Department of Defense in maintaining the quality and compliance of critical components for nuclear reactor program projects.

DLA WEAPONS SUPPORT NUCLEAR REACTOR PROGRAM

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First Article Testing and Validation ServicesThis subcontract, titled First Article Testing and Validation Services, is a total small business set-aside issued by the Department of Defense under the DLA Weapons Support ASC Commodities Division. The project involves performing First Article Testing for prime contractors to ensure that initial production units meet strict close tolerance requirements and Navy-mandated safety specifications. Work is performed in San Diego and utilizes CMM and precision gauges to validate components before they are delivered for government approval. The selected contractor is responsible for providing comprehensive documentation and test results, culminating in the delivery of a First Article Test Report and an approved test unit. This effort falls under NAICS code 541380 and is critical for validating the quality and safety of supply contracts managed by DLA Weapons Support.

DLA WEAPONS SUPPORT ASC COMMODITIES DIVISION

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Aerospace Quality Compliance & Certification ServicesThe Aerospace Quality Compliance and Certification Services subcontract involves providing technical verification and quality documentation audits for prime contractors supporting DLA Weapons Support ASC projects. The primary scope of work includes validating technical data against the DLA Master List of Technical and Quality Requirements and verifying Critical Application Item certifications specifically for ITT Aerospace part number 57802M. The selected provider must possess specialized expertise in AS9100 standards and DLA R and I quality codes to deliver comprehensive quality certification reports and compliance documentation packages. This Department of Defense requirement is managed by the DLA Weapons Support ASC Supplier Oper AE and AF Div, with the place of performance located in Tracy, California. The project falls under NAICS code 541380. Interested parties should note the response deadline of November 6, 2026, for this specialized aerospace quality assurance engagement.

DLA WEAPONS SUPPORT ASC SUPPLIER OPER AE AND AF DIV

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First Article Test (FAT) Validation and CertificationThis subcontract opportunity, issued by the Department of Defense for the DLA Weapons Support Aviation Supply Chain, involves performing First Article Testing (FAT) for internally relieved body bolts. The selected contractor will be responsible for validating the dimensions, material properties, and overall performance of a single sample unit against the technical data package. This process requires the use of Coordinate Measuring Machine (CMM) and material testing laboratory equipment to ensure full compliance. To qualify for Navy CSI validation, the contractor must hold AS9100 or ISO 9001 certification. The final deliverables for this project include a comprehensive FAT report and the return of the tested sample unit. This is a total small business set-aside under NAICS code 541380, with the place of performance located in Cherry Point. Responses are due by November 6, 2026.

DLA WEAPONS SUPPORT AVIATION SUPPLY CHAIN

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First Article Testing and Inspection ServicesThis subcontract for First Article Testing and Inspection Services involves performing specialized testing and validation for prime contractors on DLA Troop Support aerospace projects. The scope of work requires the testing of three shoulder bolt units using metrology equipment to validate material properties and dimensions according to BAC drawings. The selected provider must apply sampling standards per MIL-STD-1916 or ASQ H1331, coordinate closely with the Quality Assurance Representative, and deliver a formal First Article Test Report. The project is managed by the Department of Defense under the DLA Weapons Support ASC Commodities Division and will be performed at Tinker AFB. To be eligible for this contract, the provider must hold AS9100 certification. The solicitation was posted on October 29, 2026, with a response deadline of November 6, 2026, falling under NAICS code 541380.

DLA WEAPONS SUPPORT ASC COMMODITIES DIVISION

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Aerospace Quality Inspection and SamplingThis subcontract opportunity, titled Aerospace Quality Inspection and Sampling, is issued by the Department of Defense under the DLA Weapons Support ASC Supplier Oper AE and AF Div. The project involves performing quality verification and sampling for prime contractors on aerospace projects, specifically executing sampling plans according to MIL-STD-1916 or ASQ H1331. The scope of work requires verifying critical, major, and minor attributes with AQLs of 0.1, 1.0, and 4.0, utilizing certified Measuring and Test Equipment for dimensional inspections and providing final inspection reports and certifications of conformance. The contract is designated as a Total Small Business Set-Aside under NAICS code 541380, with the place of performance located in New Cumberland, Pennsylvania. Interested parties should note the response deadline of November 6, 2026.

DLA WEAPONS SUPPORT ASC SUPPLIER OPER AE AND AF DIV

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First Article Testing (FAT) and Production Lot Testing (PLT)This subcontract, managed by the Department of Defense under the DLA Weapons Support Land Supply Chain, involves providing technical validation and testing services for prime contractors on US Navy aerospace projects. The scope of work focuses on conducting First Article Tests and Production Lot Tests using specialized rigs to ensure the structural and functional integrity of launch bar drive links. Because these components are classified as Navy Critical Safety Items, the contractor is responsible for delivering formal test reports and certifications of compliance. The project is categorized under NAICS code 541380 and will be performed in New Cumberland. Interested parties must adhere to the timeline established by the posting date of October 29, 2026, with a response deadline set for November 9, 2026. The primary deliverables for this engagement are the FAT Certification and the corresponding PLT Test Reports.

DLA WEAPONS SUPPORT LAND SUPPLY CHAIN

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First Article Testing and Quality CertificationThis subcontract for First Article Testing and Quality Certification supports prime contractors on DLA Weapons Support ASC projects. The selected provider will perform inspections and certifications, specifically conducting First Article Testing according to PGN-09-01, preparing DD1222 forms for ESA submissions, and ensuring strict compliance with MIL-STD-129 and MIL-STD-2073-1E. Technical execution requires the use of precision gauges and Coordinate Measuring Machines to deliver certified inspection reports and First Article Test Reports. To qualify for this engagement, contractors must hold SAE AS9100 certification and maintain CMMC Level 2 compliance. The project falls under NAICS code 541380 and is managed by the Department of Defense under the DLA Weapons Support ASC Supplier Oper AE and AF Div. Responses are due by November 13, 2026, for performance located in the 17070-5002 zip code area.

DLA WEAPONS SUPPORT ASC SUPPLIER OPER AE AND AF DIV

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First Article Testing (FAT) Services

DLA WEAPONS SUPPORT FLUID HANDLING DIVISION

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Specialized Testing Services (FAT & PLT)This subcontract for Specialized Testing Services supports the DLA Weapons Support Land Supply Chain by providing First Article Test and Production Lot Test services for prime contractors. The scope of work involves validating ten initial units and all subsequent production lots in strict accordance with DI-NDTI-80809B standards. The contractor is responsible for coordinating witness testing with Government Quality Assurance Representatives and delivering all necessary signed reports and DD Form 1222/250 documentation. The project is categorized under NAICS code 541380 and will be performed in New Cumberland. Interested parties must respond by November 9, 2026, regarding this Department of Defense requirement.

DLA WEAPONS SUPPORT LAND SUPPLY CHAIN

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Production Lot Testing (PLT) for Adapter AssembliesThis subcontract involves performing Production Lot Testing for adapter assemblies to support prime contractors on DLA Weapons Support Maritime Supply Chain projects. The selected provider will execute quality and functionality validation tests in accordance with Quality Assurance Plan QAP 1TLH0 ICS3185-1, utilizing specialized laboratory equipment and testing rigs. The primary deliverable is a comprehensive test report and certification verifying that each production lot adheres to all required specifications. The project falls under NAICS code 541380 and is managed by the Department of Defense. Performance will take place in New Cumberland, Pennsylvania. Interested parties must respond by November 9, 2026, regarding this requirement posted on October 29, 2026.

DLA WEAPONS SUPPORT MARITIME SUPPLY CHAIN

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Production Lot Testing (PLT) and Validation ServicesThis subcontract, titled Production Lot Testing (PLT) and Validation Services, involves performing quality conformance validation for regulator kits on US Navy aviation projects. The selected contractor will be responsible for selecting and preparing PLT samples from production lots and managing the traceable shipping of these materials to NAWC Patuxent River for evaluation. All activities must strictly adhere to the specific PLT protocols mandated by NAWC Patuxent River, culminating in the delivery of validated samples and comprehensive test reports. Managed by the DLA Weapons Support Fluid Handling Division under the Department of Defense, the work is categorized under NAICS code 541380. The place of performance is located in Jacksonville, Florida. Interested parties should note the response deadline of November 9, 2026, for this specialized technical support requirement.

DLA WEAPONS SUPPORT FLUID HANDLING DIVISION

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in 11 days

General Info

Agency

Department Of Health And Human Services → National Institutes Of Health Nida

NAICS

541380 - Testing Laboratories and Services

Place of Performance

Set-Aside

NONE

Documents

Notice of Intent to Sole Source - Solicitation 75N95023Q00152

presolicitation

Low

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Timeline

PhaseClosed

PostedMar 9

special-notice

Response DeadlineMar 17

Deadline has passed

Submission Closed

03/17/2023, 04:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → National Institutes Of Health Nida

Contacts2 people available

OfficeBethesda, MD, 20892, USA

Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health Nida

Office AddressBethesda, MD, 20892, USA

Contacts

Kaitlyn Landi

KJ Shaikh

Full Description

PURPOSE AND OBJECTIVES: Automated patch clamp recording will be performed in 384-well plates using ND7/23 cells that are pre-treated 18 hours with compound or vehicle. Current density, voltage-dependence of activation, and voltage-dependence of inactivation, inactivation kinetics, recovery from inactivation, and use-dependent block will be measured on a minimum of 16 cells per compound. Single concentration (10 - M) experiments will be performed on 95 compounds plus two controls (vehicle, positive control compound) per plate. Cell viability will be determined before electrophysiological recording. Delivery/Deliverables: The study requires analysis of 95 compounds in an automated patch clamp assay dose dependently at least 6 concentrations) to determine IC50 for each compounds using ND7/23 (LoNav) cells stably expressing human Nav1.7. The designed study is crucial to investigate the potency of the compounds against Nav1.7 target before triaging compounds for animal studies. The deliverable will be to provide all the data generated including raw data and reports. The test materials are not transferable and shall not be used for any other purposes

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Analysis of 95 compounds in automated patch clamp assay to record sodium current using ND7/23 (LoNav) cells stably expressing human Nav1.7

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