Autonomous Physiological Control Algorithm Development

The contract seeks the development and validation of a Physiological Closed-Loop Control algorithm designed to autonomously adjust ventilator settings in real time using continuous patient physiological data. This system is intended for use in high-stakes environments such as aeromedical evacuation and prolonged field care, where access to expert medical personnel may be limited and dynamic patient conditions require immediate, precise interventions. The algorithm must be robust enough to operate reliably under challenging conditions, including variable motion, limited power, and intermittent connectivity, while ensuring patient safety and therapeutic efficacy without direct human oversight. Performance of the work is required at Frederick, Maryland, 21702, and the contract is structured as a subcontract under the Defense Health Agency, part of the Department of Defense. The solicitation was published on June 24, 2026, with a response deadline of July 15, 2026, at 4:00 PM Eastern Time. The NAICS code 541715 identifies this as a research and development service in the physical, engineering, and life sciences, indicating that the focus is on advanced algorithmic innovation rather than standard equipment procurement. The project demands rigorous validation processes to ensure clinical reliability, interoperability with existing military medical systems, and adaptability to diverse patient profiles under austere operational conditions.