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Brain Repair of Any Injured Neural Structure (BRAINS) - Proposers' Day

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ARPA-H-SN-26-153Federal

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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The Advanced Research Projects Agency for Health (ARPA-H) is initiating the Brain Repair of Any Injured Neural Structure (BRAINS) Exploratory Topic program to demonstrate the feasibility of regrowing region-specific brain tissue from transplanted precursor tissue. This initiative targets various brain regions, including the hippocampus, amygdala, thalamus, hypothalamus, striatum, cingulate cortex, substantia nigra, brainstem, and cerebellum, while specifically excluding the neocortex and spinal cord. The program is structured as an 18-month exploratory effort divided into two nine-month phases. Technical Area 1 focuses on designing tissue engineering methods to generate human iPSC-derived precursor cells, while Technical Area 2 seeks proof-of-concept for surgical engraftment of non-human fetal precursor tissues into adult brains. The program aims to deliver validated methods for generating precursor tissue and proof-of-concept surgical delivery demonstrating survival, vascularization, and appropriate connections in preclinical models. Approaches that closely mimic natural development are encouraged, while standard cell and organoid-based methods will not be considered. This specific notice serves as an announcement for a virtual Proposers Day held on June 9, 2026, to inform the scientific community ahead of the formal Innovative Solutions Opening (ISO). Interested parties must submit a mandatory solution summary in response to the ISO, with a final response deadline of February 6, 2027. Awards are anticipated to be issued as Other Transaction awards.

General Info

ARPA-H BRAINS program seeks feasible methods for regrowing region-specific brain tissue via transplantation.

Agency

Department Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)View Agency

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)View NAICS

Place of Performance

Washington, DC, USA

Set-Aside

NONE

Documents

(1)

Special Notice ARPA-H-SN-26-153 BRAINS Proposers' Day Announcement

PDF•special-notice

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)
Contacts1 person available
OfficeWashington, DC, 20005, USA
Organization / Agency
Department Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)
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Office AddressWashington, DC, 20005, USA
Contacts
BRAINS Team
contact@example.gov

Full Description

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The Advanced Research Projects Agency for Health (ARPA-H) posts this funding opportunity in support of the Brain Repair of Any Injured Neural Structure (BRAINS) Exploratory Topic program. ARPA-H anticipates multiple awards with Other Transaction award types resulting from this announcement. Interested parties are invited to review the BRAINS Special Notice ARPA-H-SN-26-153 and Innovative Solutions Opening (ISO) ARPA-H-SOL-26-148.


Parties interested in submitting a proposal in response to the ARPA-H BRAINS ISO are required (mandatory) to submit a solution summary. No awards will be made, or funding provided as a result of solution summary submissions.


The virtual Proposers' Day will be on June 9, 2026 and the recording will be available on the BRAINS program website. The event is intended to foster a greater understanding of the BRAINS program.  

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