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Computational Protein-Protein Interaction (PPI) Modeling

Active

Federal

Response Deadline11/05/2026, 12:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

AI Contract Overview

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This subcontract for the Defense Advanced Research Projects Agency involves the development of in-silico models to map protein-protein interactions in support of DARPA HUBBLE projects. The scope of work includes creating algorithms for energy landscape modeling and simulating contextual perturbations, such as small molecule interventions and PTM changes. To execute these tasks, the contractor will utilize GPU supercomputers and high-performance computing clusters. The primary deliverables for this effort are a functional in-silico PPI capability and a minimal interactome specifically for mild TBI. To qualify for this engagement, the contractor must maintain CMMC Level 1 compliance. The project falls under NAICS code 541715, with a response deadline set for November 5, 2026.

General Info

DARPA subcontract for in-silico protein interaction models and TBI interactome by November 2026.

Agency

Department Of Defense → Defense Advanced Research Projects Agcy

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

VA

Set-Aside

NONE

Documents

This scope was carved out of DARPA-PA-27-01.

The full solicitation package (7 documents), including the RFP, is on the prime solicitation, not on this scope.

View the prime solicitation

High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)

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Timeline

PostedOct 8

subcontract

Response DeadlineNov 5

Submission deadline

Response Deadline

11/05/2026, 12:00:00 PM UTCin 8 days

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Organization & Contact Information

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AgencyDepartment Of Defense → Defense Advanced Research Projects Agcy

ContactsNo contacts available

OfficeN/A

Organization / AgencyDepartment Of Defense → Defense Advanced Research Projects Agcy

Office AddressN/A

ContactsNo contact information available

Full Description

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Performs development of in-silico models to map protein-protein interactions for prime contractors on DARPA HUBBLE projects. Develops algorithms for energy landscape modeling and simulates contextual perturbations including PTM changes and small molecule interventions. Utilizes high-performance computing (HPC) clusters and GPU supercomputers. Requires CMMC Level 1 compliance. Delivers a functional in-silico PPI capability and a minimal interactome for mild TBI.

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