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Continuation of the Cardiovascular Repository for-Type 1 Diabetes (CARE-T1D) Consortium U01 (Open Competition)- Research (U01, Clinical Trial Not Allowed)

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RFA-DK-27-108Grant

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The contract outlines the continuation of the Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D) Consortium under the NIH, focusing on advancing research into cardiovascular disease (CVD) in individuals with type 1 diabetes (T1D). Cardiovascular complications remain the leading cause of death among people with T1D, and despite management of traditional risk factors such as blood glucose, blood pressure, and cholesterol, significant residual cardiovascular risk persists. The contract emphasizes the need to better understand the mechanisms behind atherosclerosis, cardiomyopathy, endothelial dysfunction, and cardiac autonomic neuropathy specific to T1D, as well as the fact that no targeted therapies currently exist to prevent or treat these cardiovascular complications. This solicitation, issued by the National Institutes of Health as part of the Special Diabetes Program, supports collaborative and interdisciplinary research efforts to deepen the understanding of CVD development unique to T1D by continuing the work of the CaRe-T1D consortium. The award mechanism is a U01 cooperative agreement for research without clinical trials, encouraging innovative research collaborations that aim to reduce morbidity and mortality associated with cardiovascular issues in T1D. The application deadline is March 10, 2027, and interested parties can direct inquiries to the NIH contact provided.

General Info

NIH contract continues CaRe-T1D research on cardiovascular disease mechanisms in type 1 diabetes.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)View NAICS

Place of Performance

Not specified

Set-Aside

NONE

Documents

(1)

RFA-DK-27-108 CARE-T1D Consortium U01 NOFO

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUSA
Organization / Agency
Department Of Health And Human Services → National Institutes Of Health
Office AddressUSA
Contacts
National Institutes of Health
contact@example.gov
+1 (555) 000-0000

Full Description

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The NIH Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D) was created to improve research on type 1 diabetes (T1D) and cardiovascular disease (CVD). Cardiovascular complications remain the top cause of death among people with T1D and greatly shorten lifespan. The mechanisms underlying atherosclerosis, cardiomyopathy, endothelial dysfunction, and cardiac autonomic neuropathy in T1D remain poorly understood. While managing traditional risk factors—such as high blood glucose, high blood pressure, and elevated cholesterol lower cardiovascular risk, a significant residual risk remains even with optimal control. In addition to atherosclerosis, both diastolic and systolic diabetic cardiomyopathy play a major role in morbidity and mortality among these patients. Currently, no therapies are specifically approved to prevent or treat these common and severe cardiovascular issues in T1D. The purpose of this NOFO is to promote collaborative and interdisciplinary research aimed at enhancing the understanding of the development of CVD in individuals with T1D and the differences with CVD in T1D by continuing the efforts of the CaRe-T1D consortium.This NOFO is associated with the Special Diabetes Program (https://www.niddk.nih.gov/about-niddk/research-areas/diabetes/type-1-diabetes-special-statutory-funding-program/about-special-diabetes-program) which funds research on the prevention, treatment, and cure of type 1 diabetes and its complications, including unique, innovative, and collaborative research consortia and clinical trials networks.

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