This Solicitation opportunity from Department Of Health And Human Services was posted on August 7, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

Top

Developing selective small-molecule modulators of

Closed

75N98026Q00988Federal

Submission Closed08/24/2026, 12:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

Active Opportunities Like This One

NAICS: 541715

New

International

Science, Technology & Innovation Data ProviderThis subcontract opportunity with the Government of Canada seeks a Science, Technology and Innovation Data Provider to support prime contractors on Public Services and Procurement Canada information product projects. The selected provider will be responsible for delivering technical datasets, innovation reports, patent data, technical specifications, and comprehensive R&D trend analysis. A critical requirement for this engagement is the provider's ability to enter into a Provider’s Master License Agreement. The project falls under NAICS code 541715 and will be performed within Canada. Interested parties must submit their responses by the deadline of March 31, 2027. This contract focuses on equipping prime contractors with the necessary technical data and innovation metrics to enhance the delivery of government information products.

Government of Canada / Gouvernement du Canada

POSTED

DEADLINE

Highway Safety Research & AnalysisThis subcontract opportunity involves providing specialized research and analysis for prime contractors working on South Dakota Department of Transportation highway safety projects. The primary objective is to evaluate flagger operations to identify safety gaps and establish effectiveness metrics. The selected provider will utilize traffic simulation software to generate data-driven operational recommendations and deliver comprehensive research reports and data analysis summaries. The project is managed under the South Dakota State Government with a response deadline of December 17, 2026. Classified under NAICS code 541715, the contract focuses on technical research and analysis to enhance highway safety protocols within the state.

South Dakota State Government

POSTED

DEADLINE

Computer Vision Algorithm Development for Aerial RefuelingThis subcontract for the U.S. Air Force focuses on the development and training of computer vision AI/ML models to support aerial refueling projects. The scope of work involves implementing object detection and tracking for aircraft and refueling booms, as well as utilizing spatial analysis to ensure precise alignment measurements. To execute these tasks, the contractor must utilize high-compute GPU clusters and advanced AI frameworks to train models based on aerial footage. The project is designated as a Total Small Business Set-Aside under NAICS code 541715, specifically targeting firms with fewer than 500 employees. Key deliverables include the final trained AI models, all associated source code, and comprehensive validation reports. Due to the nature of the defense work, strict adherence to DFARS 252.204-7012 and CMMC cybersecurity standards is mandatory. Responses are due by November 25, 2026.

POSTED

DEADLINE

Optical Design & Photonics ConsultingThis subcontract for Optical Design and Photonics Consulting supports U.S. Navy Office of Naval Research HUD projects by providing specialized optical engineering and design services for prime contractors. The scope of work involves utilizing Zemax or Code V software to design light-engine configurations, holographic optical elements, and waveguides. Key deliverables include feasibility analyses, simulation reports, and detailed optical design specifications. The opportunity is a total small business set-aside under NAICS code 541715, specifically mandated for SBIR/STTR entities with fewer than 500 employees. Contractors must adhere to NIST SP 800-171 cybersecurity requirements to ensure data protection. The response deadline for this requirement is November 25, 2026.

POSTED

DEADLINE

Information Assurance (IA) and Secure Data Exchange SpecialistThis subcontract opportunity for the U.S. Air Force focuses on research and development for Technical Data Package modernization projects. The selected specialist will develop technical frameworks for secure data exchange, conduct feasibility studies on Information Assurance protocols, and design secure transmission workflows. Key deliverables include secure exchange architecture designs and technical feasibility reports intended to support prime contractors. The contract is a Total Small Business Set-Aside under NAICS code 541715, specifically mandating SBIR/STTR compliance for firms with fewer than 500 employees. Due to the sensitive nature of the work, strict adherence to ITAR and EAR regulations is required, and all data handling systems must be CMMC-compliant. Responses are due by November 25, 2026.

POSTED

DEADLINE

Technical Research Subcontractor / ConsultantThis subcontract opportunity, issued by the U.S. Air Force under the Department of Defense, seeks a Technical Research Subcontractor or Consultant to support prime contractors on Department of War SBIR projects. The selected entity will be responsible for conducting specialized research and technical analysis to determine feasibility, developing methods to meet technical objectives, and delivering comprehensive data and research findings for final reports. The contract is a total small business set-aside under NAICS code 541715, requiring the subcontractor to have fewer than 500 employees. Key compliance requirements include adherence to CMMC standards for handling Controlled Unclassified Information and Federal Contract Information, the implementation of OCI mitigation plans, and strict following of protocols regarding Recombinant DNA or Human and Animal Subjects. Responses are due by November 25, 2026.

POSTED

DEADLINE

Senior Advisor Consultant (Biological Therapeutics SME)The Senior Advisor Consultant (Biological Therapeutics SME) is a small business set-aside subcontract under the Department of Health and Human Services, specifically within the Omas Strategic Buying Center for Professional Services. The selected consultant will provide subject matter expertise to prime contractors supporting NIH NINDS BPN-Biologics program projects. Primary responsibilities include leading biologic drug discovery for nervous system conditions, reviewing operations, and offering strategic recommendations and technical feedback on biotherapeutics trials and project milestones. Qualified candidates must possess specialized expertise in pharmaceutical development, pain management, and FDA regulatory review processes concerning toxicology and safety pharmacology. This engagement focuses on delivering high-level technical guidance to ensure the success of biologic drug discovery and development initiatives. The opportunity was posted on October 28, 2026, with a response deadline of November 5, 2026.

Omas Strategic Buying Center - Professional Services

POSTED

DEADLINE

GEO Geophysical Retrieval Algorithm DevelopmentThis subcontract, titled GEO Geophysical Retrieval Algorithm Development, involves the creation and implementation of geophysical retrieval algorithms for geostationary sensors supporting NASA Goddard Space Flight Center projects. The selected provider will work with prime contractors to develop, implement, and provide technical support for the integration and evaluation of spaceborne cloud and precipitation retrieval datasets. The project requires specialized expertise in satellite remote sensing and atmospheric science to deliver validated algorithms and comprehensive integration support. Managed through the NASA Shared Services Center under NAICS code 541715, the opportunity was posted on October 28, 2026, with a response deadline of November 2, 2026.

NASA Shared Services Center

POSTED

DEADLINE

Epidemiological Analysis & Public Health ResearchThis subcontract, titled Epidemiological Analysis and Public Health Research, supports prime contractors on CDC DNPAO projects through the Department of Health and Human Services. The scope of work involves performing advanced epidemiological analyses and public health research, specifically focusing on maternal-child nutrition. Key responsibilities include downloading and formatting surveillance data from sources such as NHANES, NHIS, BRFSS, YRBS, and NSCH, as well as designing hypothesis tests using regression models, conducting microsimulation modeling, and performing systematic reviews. The successful provider must demonstrate proficiency in R and Python to deliver critical outputs, including data tables, scientific manuscripts, and surveillance reports. The work is based in Atlanta and falls under NAICS code 541715. Interested parties should note the response deadline of November 10, 2026.

CDC Office Of Acquisition Services

POSTED

DEADLINE

Research Institution Partner (Non-Profit)This subcontract opportunity is for a registered non-profit research institution to partner with prime contractors on U.S. Air Force STTR projects. The primary objective is to conduct core scientific research to evaluate the technical feasibility of cyber resiliency within edge computing environments. Selected partners will be expected to leverage university laboratories, high-performance computing clusters, and specialized academic research software to produce research data, peer-reviewed findings, and contributions to technical reports. The opportunity is designated as a total small business set-aside under the SBIR/STTR mandate for organizations with fewer than 500 employees, falling under NAICS code 541715. Interested parties must submit their responses by November 25, 2026, at 5:00 PM. This effort is managed through the U.S. Department of Defense on behalf of the U.S. Air Force.

POSTED

DEADLINE

Edge and Fog Computing Architecture SpecialistThis subcontract opportunity for the U.S. Air Force focuses on research and development for cyber resiliency projects, specifically targeting the design of resilient architectures for fog and edge computing devices. The selected provider will be responsible for conducting feasibility studies, establishing technical milestones, and utilizing edge gateways, fog computing nodes, and embedded hardware. Key deliverables include a technical feasibility report and a Final Scientific or Technical Report. The project is a total small business set-aside under NAICS code 541715, requiring the contractor to have fewer than 500 employees. Due to the sensitive nature of the work, strict security compliance is mandatory, including CMMC Level 2 and adherence to NIST SP 800-171 and NIST SP 800-172 standards. Responses are due by November 25, 2026.

POSTED

DEADLINE

Quantum Algorithm & Benchmark DevelopmentThe Quantum Algorithm and Benchmark Development subcontract involves performing technical research and development for prime contractors on projects for the Defense Advanced Research Projects Agency. The scope of work focuses on developing benchmark instances for commercial application workloads, defining resource estimates, and translating high-value use cases into technical quantum algorithm requirements. These tasks will be executed using quantum computing simulators or early-stage quantum hardware, requiring specialized expertise in algorithm optimization and quantum complexity theory. The primary objective of the contract is the delivery of validated commercial application benchmarks. This opportunity is categorized under NAICS code 541715 and is associated with the Department of Defense. Interested parties should note the response deadline of December 30, 2026.

Defense Advanced Research Projects Agcy

POSTED

about 16 hours ago

DEADLINE

in 2 months

AI Contract Overview

The National Institutes of Health, Office of the Director, Office of Acquisitions, is seeking proposals for the development of selective small-molecule modulators through a competitive combined synopsis and solicitation issued under FAR Subpart 12.6. The solicitation, identified by number 75N98026Q00988, is open to full and open competition and intends to award a firm-fixed-price contract to the offeror providing the best value to the government. This acquisition is conducted under streamlined procedures for commercial products or services and does not exceed the simplified acquisition threshold. The requirement is unrestricted, with no set-aside provisions, and is classified under NAICS code 541715 for research and development in the physical, engineering, and life sciences, with a small business size standard of 1,000 employees. Proposals must be submitted by the deadline of August 24, 2026, and the solicitation incorporates all applicable provisions and clauses effective through the Federal Acquisition Circular dated August 7, 2026. The primary point of contact for inquiries is Johnston, Jaddua C, reachable via email at [email hidden], with the performance location based in Bethesda, Maryland.

General Info

NIH seeks firm-fixed-price contracts for small-molecule modulators via open competition, deadline August 24, 2026, Bethesda, Maryland.

Agency

Department Of Health And Human Services → National Institutes Of Health Olao

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Set-Aside

NONE

Documents

RFQ 75N98026Q00988 Developing selective small-molecule modulators of PIP4Kgamma

rfq

High

AI Contract Breakdown

Uniform Contract Format

Timeline

PhaseClosed

PostedAug 7

Solicitation

Response DeadlineAug 24

Deadline has passed

Submission Closed

08/24/2026, 12:00:00 PM UTC

Find active opportunities like this

Get full access to discover similar active contracts, track opportunities, and build proposals with AI assistance.

Organization & Contact Information

AgencyDepartment Of Health And Human Services → National Institutes Of Health Olao

Contacts1 person available

OfficeBETHESDA, MD, 20892, USA

Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health Olao

Office AddressBETHESDA, MD, 20892, USA

Contacts

JOHNSTON JADDUA C

contact@example.gov

+1 (555) 000-0000

Full Description

(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes only solicitation; proposals are being requested, and a separate written solicitation will not be issued.

(ii) The solicitation number is 75N98026Q00988. This solicitation is issued as a competitive combined synopsis/solicitation for commercial products or commercial services. The Government intends to award a contract or purchase order resulting from this solicitation using full and open competition.

This acquisition is conducted under the authority of FAR 12.603, Streamlined Solicitation for Commercial Products or Commercial Services, and is not expected to exceed the simplified acquisition threshold (if applicable).

The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, seeks to award a (Firm-Fixed-Price) to the offeror responsible whose proposal represents the best value to the Government.

(iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular effective August 7, 2026

(iv) The associated NAICS code is 541715 Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) and the small business size standard is 1000 employees.

This requirement is unrestricted.