This Subcontract opportunity from Department Of Defense was posted on September 24, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

Top

In-Silico Protein-Protein Interaction (PPI) Mapping Specialist

Closed

Federal

Submission Closed10/02/2026, 03:00:00 PM EDT

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

Active Opportunities Like This One

NAICS: 541715

New

Grant

Request for Information (RFI): Seeking New and Emerging Areas of Science Relevant to the NIDCD Mission, To Inform an Update of the NIDCD Strategic Plan for 2028-2032

Solicitation # NOT-DC-26-008

The National Institute on Deafness and Other Communication Disorders is issuing a Request for Information to gather input on new and emerging scientific areas to inform the development of its 2028-2032 Strategic Plan. In accordance with the 21st Century Cures Act, the agency is seeking suggestions from the general public, academic researchers, clinical practitioners, and advocacy groups regarding advancements in hearing, balance, taste, smell, voice, speech, and language that are not currently addressed in the 2023-2027 plan. Interested parties must submit their electronic responses by December 11, 2026. This process is voluntary and intended solely for planning purposes; it is not a solicitation for grant applications or proposals, and no awards will be made based on the submissions. Respondents are cautioned not to include proprietary or personally identifiable information, as the government cannot guarantee confidentiality and may use the submitted data in future reports or funding opportunity announcements.

National Institute On Deafness And Other Communication Disorders

POSTED

DEADLINE

Request for Information: Developing Menopause Common Data Elements

Solicitation # NOT-OD-26-111

The National Institutes of Health (NIH) has issued a Request for Information to gather input for the development of Common Data Elements (CDEs) focused on menopause. The goal is to create a standardized set of questions and response options to improve the consistency, interoperability, and reproducibility of data collected across research, clinical care, and public health settings. By harmonizing how menopause-related data is recorded, the NIH aims to better understand women's midlife health and the long-term impacts of various treatments. The NIH is seeking feedback on priority domains, including menstrual history, menopausal status, symptoms, biomarkers, and patient-reported outcomes. The proposed framework suggests a tiered approach consisting of core elements for universal collection, supplemental elements for specific thematic aims, and exploratory elements for emerging technologies and biomarkers. Additionally, the initiative seeks guidance on aligning these elements with existing health standards, ensuring representation across diverse populations, and minimizing the burden on participants and providers during implementation.

POSTED

DEADLINE

Guidance, Navigation, and Control (GNC) AlgorithmsThis subcontract focuses on the design and development of control systems and software algorithms for prime contractors supporting DARPA Anzio spacecraft projects. The scope of work includes the creation of flight control laws, autonomous guidance systems, and trajectory optimization algorithms, all developed using high-fidelity flight simulation software. The primary deliverables for this effort are control system software and detailed simulation performance reports. Managed under the Department of Defense for the Defense Advanced Research Projects Agency, the project falls under NAICS code 541715. Due to the sensitive nature of the work, contractors must maintain strict cybersecurity standards, specifically requiring compliance with NIST SP 800-171 and CMMC Level 2. The solicitation was posted on November 9, 2026, with a response deadline of December 1, 2026.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

HERMES BAA CALL: Rotating Detonation Rocket Engine-Combined Cycle (RDRE-CC) Flight Demonstration

Solicitation # FA9300-20-S-0001-CALL-RDRE-CC

The Air Force Research Laboratory Rocket Propulsion Division is seeking innovative research and development to advance Rotating Detonation Rocket Engine-Combined Cycle propulsion systems from TRL 3 to TRL 6. This effort aims to culminate in a ground-launched flight demonstration to support High-Speed Affordable Mass Munitions. The acquisition follows a two-step process, beginning with the submission of a technical white paper and rough order of magnitude cost, with selected offerors later invited to submit full technical and cost proposals. The anticipated period of performance is 36 to 48 months. Key submission requirements include a ten-page core white paper and an optional five-page technical appendix. While narrative text must be double-spaced, single-spacing is permitted within tables and graphics. Due to the presence of Controlled Unclassified Information, submissions must be sent via DoD SAFE drop requests to Contracting Officers Mathew Pierson and Kameelah Purdom, as the generic workflow inbox is no longer in use. Additionally, the government will utilize a non-government advisor from Sierra Lobo, Inc. for technical evaluation, and vetted contractors must use their CAGE code to access controlled technical Q&A documents via SAM.gov.

POSTED

DEADLINE

Venous Thrombosis (VT)

Solicitation # 80JSC026Q0014

Solicitation 80JSC026Q0014 is a combined synopsis and request for quotations issued by the NASA Johnson Space Center for a firm-fixed-price contract. The project seeks applied research and the development of current or novel approaches to surveil, reduce risk of, and prevent or treat venous thrombosis during spaceflight and exploration missions. The scope of work encompasses preflight medical screening, individual risk assessments, monitoring approaches, and both prophylactic and treatment countermeasures. Specifically excluded from this requirement are pharmaceutical treatments, AI/ML modeling, Earth-independent decision-making tools, and tissue chip or organoid pathophysiology development. The contract features a base period of performance from January 7, 2027, to September 30, 2031, with four optional years. This is a full and open competition for commercial products under NAICS code 541715. Award decisions will be based on a two-step evaluation process consisting of a compliance check followed by a trade-off analysis. Technical acceptability and past performance are weighted as significantly more important than price. Proposals must adhere to Dual-Anonymous Peer Review guidelines, separating attributable information from the technical quote. All responses must be submitted electronically by 1:00 PM CST on November 20, 2026, with technical and contractual questions due by October 30, 2026.

NASA Johnson Space Center

POSTED

DEADLINE

Solicitation # DARPA-SN-27-06

The Anzio program, managed by the Defense Advanced Research Projects Agency Tactical Technology Office, focuses on developing innovative aero-assist technologies for spacecraft to enable large, rapid, and precise orbit transfers while reducing propellant requirements. Key areas of interest include thermal protection systems, control systems and algorithms, atmospheric sensing, and lightweight aeroshells. The program specifically excludes technology areas such as communications, power management, spacecraft buses, payloads, propulsion systems, and existing orbital transfer vehicles. This specific notice, DARPA-SN-27-06, is a Special Notice for an Industry Day event scheduled for December 16-17, 2026, in Arlington, Virginia. It is not a formal solicitation for proposals or abstracts. Interested parties must register and submit PDF posters for approval by December 1, 2026. To handle Controlled Unclassified Information, participants must comply with NIST Special Publication 800-171 and maintain a CMMC Level 2 Self Assessment. All inquiries regarding the notice should be directed to [email hidden].

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

Airlift Efficiency Commercial Solutions Opening (CSO) - Amendment 01

Solicitation # FA4452-25-S-C001

The Airlift Efficiency Commercial Solutions Opening (CSO), solicitation FA4452-25-S-C001, is a competitive, unrestricted effort hosted by the 763rd Enterprise Sourcing Squadron for the Air Force Operational Energy Office. The program seeks innovative commercial technologies and services to improve airlift efficiencies for military and commercial transport aircraft. The solicitation follows a two-step process consisting of an initial Solution Brief and a subsequent Detailed Approach for invited participants. Awards will be made as Firm-Fixed Price contracts or Other Transaction Agreements, with evaluations weighted equally across technical merit, importance to the agency, and price. The first Area of Interest (AOI) focuses on a dual-use propulsion system engine with 35,000 to 50,000 lbs of thrust, intended for the C-17 Globemaster and Blended Wing Body (BWB) platforms. Key requirements include compliance with current and future emissions standards, entry into service by 2030, and a scalable production plan capable of delivering up to 80 engines per month by 2037. The government strongly encourages cost-share arrangements or unconventional project financing to mitigate development risks. Solution briefs for this AOI are due by March 13, 2025, and must be submitted as unclassified documents.

POSTED

DEADLINE

Polar Rover for Observation, Mapping, and In-Situ Exploration (PROMISE) Mission

Solicitation # 2027_PROMISE

NASA Marshall Space Flight Center

POSTED

DEADLINE

Helmet-Mounted First-Person View Display System

Solicitation # SOFATL-KP_27-06

POSTED

DEADLINE

ACC-DTA Commercial Solutions Opening (CSO)

Solicitation # W912CH-26-S-0001

The Army Contracting Command – Detroit Arsenal (ACC-DTA) Commercial Solutions Opening (CSO), solicitation W912CH-26-S-0001, serves as a rapid-acquisition gateway to transition innovative commercial technologies into active defense programs. Supporting a diverse customer base including the Intelligence and Security Command (INSCOM) and six Portfolio Acquisition Executives, this vehicle focuses on enhancing the development, integration, and sustainment of ground vehicle systems to improve Army modernization and readiness. The CSO utilizes a streamlined, merit-based, multi-phased evaluation process consisting of solution briefs, presentations, and commercial solution proposals. Awards may be issued through 2028 as FAR Part 12 commercial contracts, non-FAR transaction agreements under 10 U.S.C. 4022, or Cooperative Agreements under 31 U.S.C. 6305. The scope of the CSO is broad and evolves through frequent amendments, encompassing various Areas of Interest (AoI). Key initiatives include the FALCONS prototype effort for long-range reconnaissance sensors with funding ceilings up to 30 million dollars, the TIGER Readiness and Hackathon programs focused on Abrams Main Battle Tank engine supply chain resilience, and the procurement of Mobile Camouflage Systems, Counter-UAS detection, and domestically produced hand tools. Evaluation is based on technical merit, the realism of the performance schedule, and price affordability. To be eligible for award, companies must be registered in the System for Award Management (SAM) with a Unique Entity ID and must comply with the Buy American Act and Specialty Metals clauses.

POSTED

DEADLINE

Systems for Phenotypic Evaluation, Clinical Trajectories, Response, and Agency (SPECTRA)

Solicitation # ARPA-H-SOL-26-163

The Systems for Phenotypic Evaluation, Clinical Trajectories, Response, and Agency (SPECTRA) program, issued by the Advanced Research Projects Agency for Health (ARPA-H) Proactive Health Office under solicitation ARPA-H-SOL-26-163, seeks innovative solutions to identify and act upon autism trajectories across the lifespan. The program focuses on the nonlinear interactions of genetic, biological, behavioral, and environmental factors to move toward personalized care. The scope is divided into four Technical Areas: TA1 focuses on multi-factor analysis and trajectory identification; TA2 involves population-scale modeling and data integration; TA3 centers on precision intervention and trajectory testing; and TA4 targets technologies for communication, quality of life, and embedded assessment. Awards will be made using Other Transaction (OT) instruments through a two-stage submission process consisting of a Solution Summary and a Full Proposal. Technical performance is monitored via a milestone-based system with evaluation gates at Month 10, Month 22, and a final evaluation at Month 46. Key requirements include strict adherence to HIPAA Privacy Rule de-identification standards, the implementation of independent data safety monitoring boards for harm surveillance, and the disclosure of any organizational conflicts of interest. Submissions must follow specific formatting guidelines, including the use of Avenir Next LT Pro font for summaries and a multi-volume structure for full proposals, with a response deadline of December 2, 2026.

Advanced Research Projects Agency For Health (arpa-H)

POSTED

DEADLINE

Exploratory Advanced Research (EAR) Program FY 2027 Data Science Solicitation

Solicitation # 693JJ3-27-BAA-0002

The Exploratory Advanced Research (EAR) Program FY 2027 Data Science Solicitation, identified as 693JJ3-27-BAA-0002, is a Broad Agency Announcement issued by the Federal Highway Administration (FHWA) within the Department of Transportation. The program seeks to identify and fund high-risk, high-payoff research focused on applying emerging and advanced data analytic techniques to improve the safety, durability, efficiency, and environmental impact of highway and intermodal transportation systems. Key objectives include expanding the community of researchers in data science for transportation and increasing the availability of well-documented highway transportation data. The expected period of performance for awarded projects is 60 months, with most instruments anticipated to be firm-fixed-price contracts, although cost-reimbursement arrangements may be permitted for awardees with approved accounting systems. The government will utilize a best-value determination based on an integrated evaluation of technical capability, past performance, and cost/price. Technical capability is the most important non-price factor, and combined non-price factors are approximately equal in weight to cost/price. The selection process involves a two-phase approach, beginning with a project concept paper rated as acceptable or not acceptable, followed by a formal project proposal. While there are no exclusive set-asides, the solicitation strongly encourages submissions from small businesses, including disadvantaged, veteran-owned, and woman-owned concerns, as well as Historically Black Colleges and Universities and Minority Institutions. Proposals must be submitted in electronic PDF format and organized into three volumes: a technical proposal with a 20-page limit, cost and pricing data, and supplemental information regarding intellectual property. Key requirements include registration in the System for Award Management (SAM), the provision of a Unique Entity Identifier (UEI), and the submission of a Small Business Subcontracting Plan for non-small business entities with awards exceeding 900,000 dollars. Additionally, the FHWA will maintain unlimited rights to any software and source code delivered under the contract. The response deadline for this solicitation is December 21, 2026.

693JJ3 Acquisition And Grants Mgt

POSTED

about 23 hours ago

DEADLINE

in about 1 month

AI Contract Overview

This subcontract for the Defense Advanced Research Projects Agency involves the computational development of in-silico capabilities to map protein-protein interactions for DARPA HUBBLE projects. The specialist will utilize high-performance computing clusters and molecular dynamics simulation tools to develop predictive models for PPI fingerprinting and map interaction spaces specifically related to traumatic brain injury. The primary deliverables include a functional mapping capability and a comprehensive report identifying diagnostic and therapeutic targets for traumatic brain injury. This opportunity is categorized under NAICS code 541715 and requires CMMC Level 1 compliance. The place of performance is located in Arlington, with a response deadline of October 2, 2026.

General Info

DARPA subcontract for TBI protein-protein interaction mapping using HPC and molecular dynamics.

Agency

Department Of Defense → Defense Advanced Research Projects Agcy

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Arlington, VA, USA

Set-Aside

NONE

Documents

This scope was carved out of DARPA-PA-26-10_DRAFT.

The full solicitation package (1 document), including the RFP, is on the prime solicitation, not on this scope.

View the prime solicitation

HUBBLE DRAFT Program Announcement (PA)

AI Contract Breakdown

Uniform Contract Format

No documents to break down

The breakdown needs solicitation documents. None were found from this contract's source.

Timeline

PhaseClosed

PostedSep 24

subcontract

Response DeadlineOct 2

Deadline has passed

Submission Closed

10/02/2026, 03:00:00 PM EDT

Find active opportunities like this

Get full access to discover similar active contracts, track opportunities, and build proposals with AI assistance.

Organization & Contact Information

AgencyDepartment Of Defense → Defense Advanced Research Projects Agcy

ContactsNo contacts available

OfficeN/A

Organization / AgencyDepartment Of Defense → Defense Advanced Research Projects Agcy

Office AddressN/A

ContactsNo contact information available

Full Description

Performs computational development of in-silico capabilities to map protein-protein interactions for prime contractors on DARPA HUBBLE projects. Develops predictive models for PPI fingerprinting and maps interaction spaces associated with traumatic brain injury (TBI) using HPC clusters and molecular dynamics simulation tools. Requires CMMC Level 1. Delivers a functional mapping capability and a report identifying TBI diagnostic and therapeutic targets.