This Government Contract opportunity from Government of Canada was posted on May 6, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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Method Development and Validation Support Services

Closed

International

Submission Closed05/15/2026, 10:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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NAICS: 541715

New

Federal

Research & Development – Advanced Technology PrototypingThis contract pertains to advanced technology prototyping under a DARPA-managed research and development initiative, focusing on technical development that integrates systems engineering, algorithm design, and hardware-software co-design. It is structured as a subcontract with a multi-phase execution approach, requiring innovative solutions that push the boundaries of current capabilities in defense-related technologies. The work will involve iterative prototyping and demonstration of novel systems, with each phase building on the outcomes of the prior one to validate technical feasibility and operational relevance. The opportunity is open for responses until October 19, 2026, and is classified under NAICS code 541715 for research and development in the physical, engineering, and life sciences. Performance is expected to be conducted under the auspices of the Department of Defense, though specific location details are not defined. The contract is part of a broader effort to accelerate the transition of cutting-edge research into practical prototypes, with an emphasis on rapid development cycles and cross-disciplinary collaboration. Respondents must demonstrate expertise in high-risk, high-reward technology development aligned with DARPA’s strategic goals, and proposals are expected to address scalability, manufacturability, and potential for operational deployment.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

Regenerative Medicine for Tissue RepairThe contract titled Regenerative Medicine for Tissue Repair is a subcontract issued by the Defense Health Agency under the Department of Defense to advance research into regenerative therapies aimed at accelerating tissue repair in combat-related injuries. The focus is on innovative approaches such as stem cell applications and biomaterials designed to restore function and reduce recovery time for severe battlefield trauma. The opportunity was posted on August 7, 2026, with a response deadline of October 30, 2026, at 4:00 PM, providing potential applicants a limited window to submit proposals. The North American Industry Classification System code 541715 indicates this effort falls under research and development in the life sciences, specifically in the biomedical field. Performance of the work is expected to be conducted in Frederick, Maryland, aligning with existing military and medical research infrastructure in the region. This subcontract represents a strategic Department of Defense initiative to bridge cutting-edge medical science with urgent battlefield medical needs.

Defense Health Agency

POSTED

DEADLINE

Pathogen-Agnostic Sepsis CountermeasuresThe contract centers on the research and prototype development of pathogen-agnostic countermeasures for sepsis, targeting treatments or diagnostics effective against multiple infectious agents including Pseudomonas aeruginosa and Shigella. This initiative seeks to identify novel therapeutic or diagnostic platforms that function independently of the specific causative pathogen, addressing the critical challenge of sepsis management in heterogeneous infection scenarios. The work is funded under a subcontract arrangement by the Defense Health Agency within the Department of Defense, reflecting a strategic focus on advancing military and civilian medical readiness through innovative biomedical solutions. The project is tied to NAICS code 541715, categorizing it under research and development in the physical, engineering, and life sciences. The opportunity was posted on August 7, 2026, with a response deadline of October 30, 2026, and the performance location is designated as Frederick. While no set-aside provisions or point of contact details are provided, the emphasis on broad-spectrum effectiveness underscores the need for scalable, broadly applicable technologies that can rapidly respond to complex, multi-pathogen sepsis cases. The contract aims to accelerate the transition from concept to prototype, prioritizing solutions with the potential for immediate deployment in clinical and operational settings.

Defense Health Agency

POSTED

DEADLINE

Rat PK for the DYT1 lead compound

Solicitation # 75N98026Q00987

The National Institutes of Health, Office of the Director, Office of Acquisitions, is soliciting proposals under solicitation number 75N98026Q00987 for research and development services related to rat pharmacokinetics for the DYT1 lead compound. This is a competitive combined synopsis and solicitation issued under FAR Subpart 12.6 for commercial items, utilizing full and open competition without a separate written solicitation. The contract will be awarded on a firm-fixed-price basis to the offeror providing the best value to the government, with no set-aside designated and the requirement remaining unrestricted. The North American Industry Classification System code is 541715, with a small business size standard of 1,000 employees, and the solicitation is conducted under the streamlined procedures authorized by FAR 12.603, not expected to exceed the simplified acquisition threshold. Proposals must be submitted by the deadline of August 24, 2026, and all terms and conditions are governed by the Federal Acquisition Circular effective August 7, 2026. The work is to be performed in support of the NIH in Bethesda, Maryland, with primary point of contact being John Johnston, reachable via email at jaddua.johnston@nih.gov. This acquisition is not tied to any specific location beyond the agency’s office in Bethesda and is intended to procure commercial services in the field of physical, engineering, and life sciences research, excluding nanotechnology and biotechnology. All interested parties must respond through the provided SAM.gov link and adhere to the submission requirements outlined in the solicitation document.

National Institutes Of Health Olao

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Maximum Tolerated Dose (MTD) Evaluation of PIP4Kga

Solicitation # 75N98026Q00989

The National Institutes of Health, Office of the Director, Office of Acquisitions, is soliciting proposals under solicitation number 75N98026Q00989 for the Maximum Tolerated Dose (MTD) Evaluation of PIP4Kga, utilizing a commercial items acquisition process under FAR Subpart 12.6. This combined synopsis/solicitation is issued as a competitive, full and open opportunity using a firm-fixed-price contract structure, with no set-aside designated, and is not expected to exceed the simplified acquisition threshold. The requirement falls under NAICS code 541715 for Research and Development in the Physical, Engineering, and Life Sciences, with a small business size standard of 1,000 employees, and is unrestricted to all eligible offerors. Proposals must be submitted by the deadline of August 24, 2026, and the solicitation incorporates all applicable provisions and clauses in effect as of August 7, 2026. The NIH seeks the best value proposal from responsible vendors capable of delivering the required research and development services, which will involve evaluating the MTD of PIP4Kga through scientifically rigorous methodologies. The place of performance and specific technical requirements are not detailed in the public notice, but inquiries should be directed to the primary point of contact, Johnstons Johnston, at jaddua.johnston@nih.gov. The acquisition is being conducted under the streamlined procedures of FAR 12.603, eliminating the need for a separate written solicitation, and all responses must be submitted through the designated SAM.gov portal. The contract award will be made based on factors demonstrating overall value, including technical capability, past performance, and price competitiveness.

National Institutes Of Health Olao

POSTED

DEADLINE

Synthesis of compounds and intermediates

Solicitation # 75N98026Q00970

The National Institutes of Health, Office of the Director, Office of Acquisitions, is seeking proposals for the synthesis of compounds and intermediates under solicitation number 75N98026Q00970, issued as a combined synopsis and solicitation in accordance with FAR Subpart 12.6. This procurement is conducted under simplified procedures for commercial items, employing full and open competition without solicitation of small business set-asides, and is not anticipated to exceed the simplified acquisition threshold. The contract will be awarded on a firm-fixed-price basis to the offeror whose proposal provides the best value to the government, assessed on technical merit and cost-effectiveness. The requirement falls under NAICS code 541715 for research and development in the physical, engineering, and life sciences, with a small business size standard of 1,000 employees. Proposals must be submitted by the response deadline of August 24, 2026, and the solicitation incorporates all applicable Federal Acquisition Regulation clauses in effect as of August 7, 2026. The work is to be performed in Bethesda, Maryland, with all correspondence directed to the designated point of contact, Johnstons Jaddua C, via email or phone. This solicitation is not a request for a separate written document, as the announcement serves as the complete solicitation package under streamlined commercial procurement rules. Offerors are expected to respond directly through the SAM.gov portal using the provided link.

National Institutes Of Health Olao

POSTED

DEADLINE

NextSTEP-3 Appendix B: Moon Base Demonstrations

Solicitation # M2M-MSFC-0001

The solicitation for NextSTEP-3 Appendix B: Moon Base Demonstrations, issued under solicitation number 80MSFC26R0003 by NASA Marshall Space Flight Center, seeks industry-led demonstrations to advance the development of a permanent lunar base at the Moon’s South Pole, aligning with national space policy goals of sustained lunar presence and deep space exploration readiness. This initiative targets technology readiness levels 6 and above to bridge the gap between innovation and operational mission needs, with an emphasis on architectural studies, risk reduction, and capability maturation rather than hardware production. The procurement employs a two-step process: initial White Paper submissions followed by invited full proposals under a Multi-Award Task Order Contract (MATOC) structure, with all awards structured as Firm-Fixed-Price contracts featuring performance-based milestone payments. The solicitation operates under a dual-path approach, combining Directed-Topic Calls that address specific, evolving mission needs with Open-Topic Calls that invite broader, unanticipated innovations—though submissions duplicating Directed-Topic concepts will be deemed ineligible. Evaluation is based on a non-trade-off, best-value selection process where Technical Capability (including Capability and Past Performance) is weighted at 1,000 points and must meet minimum thresholds for eligibility, while Price is assessed solely for reasonableness and completeness and does not factor into ranking. Proposals must adhere to strict formatting rules, including page limits and submission as a single searchable PDF, with key personnel qualifications, organizational conflict of interest plans, and intellectual property disclosures required as attachments. All contractors must maintain active SAM.gov registration, submit required certifications and representations, and comply with NASA-specific clauses related to data rights, payments, changes, subcontracting, whistleblower protections, and safety and liability waivers. Performance will be conducted under the NASA FAR Supplement, with invoicing required through the NASA Shared Services Center and all delivery and inspection terms left intentionally unspecified, reinforcing the analytical nature of deliverables—reports, models, simulations, and feasibility studies—rather than physical products. The contracting office at Huntsville, Alabama, remains the point of contact, with questions directed to the designated Contracting Officer, and submissions must be completed by the stated deadline to remain valid.

NASA Marshall Space Flight Center

POSTED

DEADLINE

Developing selective small-molecule inhibitors of

Solicitation # 75N98026Q00986

The National Institutes of Health, Office of the Director, Office of Acquisitions, is seeking proposals through a competitive combined synopsis and solicitation for the development of selective small-molecule inhibitors, issued under FAR Subpart 12.6 as a streamlined commercial acquisition not expected to exceed the simplified acquisition threshold. The solicitation number is 75N98026Q00986, with responses due by August 24, 2026, and the contract will be awarded on a firm-fixed-price basis to the offeror providing the best value to the government. This acquisition is unrestricted and intended for full and open competition, with the NAICS code 541715 indicating research and development in the physical, engineering, and life sciences, though the provided description references a different NAICS code which may reflect a discrepancy. The offering organization is located at 20892 Bethesda, MD, with John A. Johnston, Jr. as the primary point of contact via email and phone. The solicitation incorporates all Federal Acquisition Circular provisions and clauses effective August 7, 2026, and no separate written solicitation will be issued.

National Institutes Of Health Olao

POSTED

DEADLINE

MTEC Solicitation Summary: Fiscal Year 2026 Multi-Topic Request for Project Proposals

Solicitation # MTEC-26-04-MultiTopic

The Medical Technology Enterprise Consortium (MTEC) is soliciting innovative medical prototype solutions through its Fiscal Year 2026 Multi-Topic Request for Project Proposals, targeting critical gaps in military medical readiness across fourteen distinct Focus Areas. These areas span a broad spectrum of battlefield medical challenges, including prevention of infections from high-priority pathogens like Pseudomonas aeruginosa and Shigella, development of pathogen-agnostic sepsis countermeasures, reduction of barriers to mental health help-seeking, optimization of musculoskeletal injury treatment, advancement of non-addictive analgesics, and creation of sensor systems to monitor blast and blunt trauma exposure. Proposals must align strictly with one Focus Area and demonstrate clear military relevance, with solutions intended for use in austere or contested environments, supporting pre-hospital and early care stages (Roles 1 and 2). All submissions must be prototype-scale projects with a minimum Technology or Knowledge Readiness Level of 3, and must not have been previously submitted to MTEC within the last two years. Proposals are submitted via an Enhanced White Paper format as Stage 1 of a two-stage acquisition process, with selected candidates invited to submit detailed cost proposals in Stage 2. Funding is expected to range from $2 to $3.5 million per award over a 2 to 3-year performance period, contingent on available federal appropriations and technical merit. The solicitation encourages teaming among MTEC members to address complex technical requirements, and leverages a new member directory to facilitate collaboration. Proposals must adhere to the definition of a prototype under 10 U.S.C. § 4022 and may include medical devices, drugs, biologics, knowledge products, or novel delivery systems, but explicitly exclude vaccines, burn wound solutions, discovery-stage efforts, and IV-based interventions where specified. The deadline for Enhanced White Paper submissions is October 30, 2026, and successful projects may be eligible for non-competitive follow-on awards based on demonstrated progress and milestone achievement.

Defense Health Agency

POSTED

DEADLINE

Multi-Domain Force Applications and Traffic Management for Unmanned Aircraft Systems (M-FAT)

Solicitation # FA8750-25-S-7004

The Department of the Air Force, through the Air Force Research Laboratory’s Rome Research Site, is soliciting white papers under Broad Agency Announcement FA8750-25-S-7004 for research and development in Multi-Domain Force Applications and Traffic Management for Unmanned Aircraft Systems, with an open submission window until August 4, 2030. This two-step process invites initial white papers that must be no longer than four pages, double-spaced, and must include a technical summary, task objective, and proposed deliverables; formal proposals are accepted only by invitation after the initial review. The BAA targets advancements in electronic warfare, cyberspace operations, command and control automation, and low-collateral defeat technologies to counter small unmanned aircraft systems, particularly swarms, with emphasis on blurring the lines between cyber and electronic attack, integrating AI and machine learning for automated decision-making, and developing autonomous interceptors with integrated effects. Additional focus areas include enhancing sensor systems for detection and tracking, creating a cyberspace effects library, and advancing unmanned aircraft traffic management systems to safely integrate with existing air traffic infrastructure. Communication resilience is also sought through novel waveforms, networking protocols, and AI-driven spectrum management. Estimated funding totals approximately $499 million, with individual awards typically ranging from $500,000 to $20 million, though awards up to $99 million are possible. Multiple awards are anticipated, and the government may issue FAR-based contracts, grants, cooperative agreements, or Other Transactions, including prototype agreements with potential follow-on production pathways. Submission deadlines are recommended by fiscal year through 2029, with the final deadline set for August 4, 2030. Offerors must be registered in SAM, disclose organizational conflicts of interest, submit required security documentation including senior and key person profiles, and comply with NIST SP 800-171 cybersecurity baselines. Proposals are evaluated primarily on technical merit and mission alignment, with cost as a lesser factor, and must pass pre-award assessments for science and technology protection and financial responsibility under 2 CFR 200.206. All communications regarding technical matters must be directed to designated points of contact, and only contracting officers may commit the government. Submission noncompliance with formatting, content, or procedural instructions may result in rejection or reduced scores.

POSTED

DEADLINE

REQUEST FOR INFORMATION: Solutions to Enhance US Rocket-Based Combined Cycle (RBCC) Propulsion Technologies

Solicitation # RFIFA930026R0001

This Request for Information (RFI) issued by the Air Force Research Laboratory’s Rocket and Space Propulsion Division seeks industry input to inform future development and demonstration efforts in Rocket-Based Combined Cycle (RBCC) propulsion technology, with a primary focus on Rotating Detonation Rocket Engines (RDRE) using storable, non-cryogenic propellants such as High Test Peroxide (HTP) combined with Rocket Propellant (RP) or Jet Fuel. The goal is to identify current capabilities, technology gaps, and viable pathways toward systems that minimize weight and logistics, maximize scalability and operational range, and enable flight demonstrations at relevant velocities and altitudes to achieve TRL-6. Key technical requirements include incorporating an RDRE as the primary combustor capable of ignition, throttling, and relight under flight conditions; utilizing thermal management systems for extended burn times; ensuring propellant compatibility with austere environments; and integrating a compact, scalable air inlet and flowpath that supports smooth mode transitions between rocket and air-breathing propulsion, with the air-breathing system providing primary thrust after acceleration. The RFI specifically excludes cryogenic propellants, turbine-based combined cycles, and systems requiring exotic materials or complex manufacturing. Respondents must provide written submissions not exceeding ten total pages in Microsoft Word using 11-point font, with administrative details—such as company name, NAICS business size, Cage Code/SAM UEI, organization address, and point of contact—excluded from the page limit. Responses are expected to address six core areas: overall RBCC system characteristics, state-of-the-art propulsion technologies requiring advancement, suitable storable propellants and their logistics and safety profiles, available ground and flight test facilities, computational modeling tools for design and analysis, and potential flight test platforms with estimated timelines and costs. All information submitted will be treated as market research and will not be used to select vendors for contract award, nor will the government compensate respondents for costs incurred. Proprietary information marked as such will be safeguarded in accordance with government regulations, though the government assumes no liability for improperly labeled proprietary data. Responses are due no later than August 10, 2026, and must be submitted electronically to the designated contracting officers. This RFI does not represent a commitment to issue a future solicitation, and any future contract opportunities will be announced on SAM.gov. Participation in this RFI does not guarantee eligibility for future procurements.

POSTED

DEADLINE

RFI for Next Generation Hypersonic Cruise Missiles

Solicitation # DARPA-SN-26-93

The U.S. Defense Advanced Research Projects Agency is seeking industry input through a Request for Information to shape the future acquisition strategy for a potential program focused on next-generation hypersonic cruise missiles. This RFI, issued under solicitation number DARPA-SN-26-93 and posted on August 7, 2026, with responses due by October 6, 2026, aims to refine technical specifications, validate programmatic assumptions, and guide the development of a competitive solicitation. The agency is particularly interested in fostering innovative partnerships between traditional defense contractors, non-traditional industry players, technology developers, and specialized test and evaluation providers to advance capabilities in this high-priority domain. Responses will directly inform DARPA’s understanding of current industry capabilities and potential pathways for innovation. The effort falls under NAICS code 541715, indicating a focus on research and development in the physical, engineering, and life sciences. All submissions must be directed to the TTO Acquisition Team at DARPA-SN-26-93@darpa.mil, and no set-aside status is anticipated, meaning the opportunity is open to all eligible entities regardless of size or status. The office is located in Arlington, Virginia, and while the place of performance has not been specified, the program is expected to involve nationwide collaboration and testing. This RFI serves as a precursor to a future formal solicitation, positioning industry to align its capabilities with DARPA’s strategic goals in hypersonic systems and to position itself for upcoming contract opportunities.

Defense Advanced Research Projects Agcy

POSTED

about 20 hours ago

DEADLINE

in about 2 months

AI Contract Overview

The contract seeks services to develop, validate, and document analytical methods for emerging contaminants or novel food matrices, with the explicit requirement that these methods achieve equivalency to those approved by the Canadian Food Inspection Agency. The work must adhere to rigorous scientific standards to ensure accuracy, reliability, and regulatory acceptance within the Canadian food safety framework. All deliverables must include comprehensive documentation to support implementation and verification by CFIA personnel or authorized third parties. The contract is classified as a subcontract under NAICS code 541715, indicating it relates to scientific research and development services. It is issued by the Government of Canada through the Canadian Food Inspection Agency, with the place of performance located in Canada. The solicitation was posted on May 6, 2026, and responses are due by May 15, 2026, at 10:00 PM Eastern Time. While details such as set-aside status and point of contact are not provided, the focus remains squarely on advancing analytical capabilities in food safety testing through scientifically sound and CFIA-compliant methodologies.

General Info

Develop and validate analytical methods for emerging contaminants ensuring CFIA-approved equivalency.

Agency

Government of Canada → Canadian Food Inspection AgencyView Agency

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)View NAICS

Place of Performance

Canada, CAN

Set-Aside

NONE

Documents

(0)

No documents available

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Timeline

PhaseClosed

PostedMay 6

subcontract

Response DeadlineMay 15

Deadline has passed

Submission Closed

05/15/2026, 10:00:00 PM UTC

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Organization & Contact Information

AgencyGovernment of Canada → Canadian Food Inspection Agency

ContactsNo contacts available

OfficeN/A

Organization / Agency

Government of Canada → Canadian Food Inspection Agency

View Agency Profile

Office AddressN/A

ContactsNo contact information available

Full Description

Develop, validate, and document analytical methods for emerging contaminants or new food matrices, ensuring equivalency to CFIA-approved methodologies.