Proactive Health Office (PHO) Mission Office Innovative Solutions Opening (ISO)
Contract Overview
Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.
AI Contract Overview
The ARPA-H Proactive Health Office (PHO) Mission Office Innovative Solutions Opening (ISO) solicitation (ARPA-H-SOL-24-106) is a broad, multi-year opportunity aimed at funding innovative projects designed to improve the healthspan and health outcomes of Americans before disease onset or decline in quality of life. The solicitation focuses on three key areas: enhancing population-level access to and participation in disease prevention and wellness behaviors; developing novel early-detection technologies and prophylactic interventions; and creating system-level innovations to enable effective delivery of proactive health solutions. ARPA-H seeks proposals that demonstrate strong scientific and technical merit, potential impact aligned with its mission, relevant proposer capabilities, and reasonable cost proposals. Submissions are accepted on a rolling basis through March 5, 2029, with proposals and solution summaries required to be submitted electronically via the ARPA-H Solution Submission Portal using prescribed templates. This solicitation is structured as an Other Transaction (OT) agreement rather than a traditional FAR-based contract, governed by a referenced model OT Agreement that allows negotiation of terms with sole discretion held by the government’s Agreements Officer (AO). The contract incorporates by reference numerous federal regulations, including standards for human subjects research, animal welfare, controlled unclassified information (CUI), and health IT protocols consistent with HHS mandates. Proposals involving human or animal subjects must comply with applicable federal protections and provide detailed disclosures. Organizational Conflicts of Interest, Research Security disclosures, and Intellectual Property assertions are mandatory parts of submissions, with detailed mitigation plans required for any conflicts or foreign influence considerations. The evaluation process is merit-based, emphasizing innovation and mission relevance over lowest cost, with multiple awards anticipated. Cost proposals must adhere to updated documentation requirements, including thresholds for supporting materials and equipment purchases. Payment will be handled via electronic invoicing through the Payment Management Services platform, with no specific payment office or accounting data provided upfront. The solicitation specifies clear marking requirements for proprietary and CUI information but does not impose physical packaging or bar-coding mandates due to the primarily electronic submission format. Award terms, milestones, performance periods, and place of performance are to be proposed by offerors and negotiated post-selection, with a preference for U.S.-based performance but allowance for non-U.S. participation except for entities affiliated with covered foreign countries as defined by law. Overall, this solicitation presents a flexible, innovative contracting vehicle designed to attract cutting-edge health solutions that address population health challenges through technology, prevention, and system transformation.
General Info
Agency
NAICS
Place of Performance
DC, USASet-Aside
Timeline
Response Deadline
Organization & Contact Information
Full Description
The Proactive Health Office (PHO) at ARPA-H is seeking solutions to improve the healthspan and health outcomes of Americans prior to the onset of disease and/or the development of diminished quality of life from illness. Specifically, PHO hypothesizes that 1) population-level improvements in access to and uptake of disease prevention and wellness-promoting behaviors and 2) development of novel early-detection methods and prophylactic interventions could drastically improve the health of American throughout their lives, and 3) that system level innovations are required for delivery of proactive health effectively.
- Solution summary submissions must be submitted to: https://solutions.arpa-h.gov
- Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/
- Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/
Amendment 4 is effective immediately; however, if an entity has previously submitted a Solution Summary and a proposal, no action is required related to changes described in the amendment. If only a Solution Summary has been submitted; any future proposal must comply with this amendment.
Amendment 04 includes the following changes:
- Updated Administrative and National Policy Requirements document (Note other Bundle of Attachment documents are unchanged)
- Minor changes throughout the ISO, including, but not limited to: Updating the name from ARPA-H Solution Submission Portal to ARPA-H Solutions Site, notation in paragraph 2.3, and revised language in Section 6.1 Research Security Disclosures to align with the updated Bundle of Attachments document.