RNomics Outreach and Coordination (ROC) Center
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The NIH Common Fund, in collaboration with other NIH Institutes and Centers, is preparing to launch the RNomics program to advance the study of the complete RNA landscape in biological systems, encompassing sequences, modifications, structures, locations, interactions, and functions. This initiative will foster the development of transformative tools and resources to enable integrated analysis of the RNome, with the goal of deepening understanding of human health and disease. The program will consist of four components: technology enhancement centers, transformative technologies, molecular standards, and a coordinating center, though no applications are currently being accepted. This notice serves to inform potential applicants and encourage the formation of collaborations and robust research proposals ahead of future funding opportunities. The RNomics Outreach and Coordination (ROC) Center will act as the central hub for the consortium, responsible for data management, community engagement, and cross-project coordination. It will build and maintain a centralized data portal, establish and promote standardized data formats, coordinate the validation and benchmarking of RNA technologies, and lead large-scale data analyses across the program. The ROC Center will also drive outreach, training, and resource sharing initiatives to broaden adoption of RNomics tools and ensure the long-term accessibility and sustainability of all generated data assets. The National Institutes of Health, under the Department of Health and Human Services, is the issuing agency, with inquiries directed to the Common Fund RNomics Program via cfrnomics@od.nih.gov, and the forecasted posting date for the official solicitation is August 5, 2026.
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The NIH Common Fund, in partnership with other NIH Institutes and Centers, plans to issue Notices of Funding Opportunity (NOFOs) for the RNomics program, which seeks to develop tools for studying the full set of RNA molecules (the RNome) in cells and tissues. The program will support technologies and resources that enable integrated analysis of RNA sequences, modifications, structures, locations, interactions, and functions to advance understanding of health and disease. RNomics includes four initiatives: technology enhancement centers, transformative technologies, molecular standards, and a coordinating center. Applications are not being solicited at this time. This notice is being provided to give potential applicants time to develop meaningful collaborations and strong projects.
This NOFO will establish the RNomics Outreach and Coordination (ROC) Center. The ROC Center will serve as the consortium's hub for data management, coordination, and community engagement. It will develop a central RNomics data portal, support the development and use of data standards, coordinate technology validation and benchmarking, lead consortium-wide data analysis, and support outreach, training, and sharing of RNomics resources. The center will also plan for long-term availability and maintenance of RNomics data assets.
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