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Somatic Mosaicism across Human Tissues (SMaHT) Program: Experimental and Computational Technology Development (RM1 Clinical Trial Not Allowed)

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The National Institutes of Health, under the Department of Health and Human Services, is issuing a forecast for the Somatic Mosaicism across Human Tissues (SMaHT) Program focusing on Experimental and Computational Technology Development. This initiative aims to advance the understanding of biological processes and disease mechanisms by developing, optimizing, and validating cost-effective technologies for somatic mutation detection and functional interpretation. Building upon the multi-omic datasets established in Stage 1, this second stage emphasizes the creation of rigorous benchmarks and the dissemination of tools to support the discovery of mutations across human tissues. Awardees will be expected to work collaboratively with other SMaHT Stage 2 initiatives to integrate these validated technologies into production workflows, data releases, and broader community resources. This multidisciplinary effort is designed to enhance the detection and analysis of somatic mutations across all three germ layers. Interested parties can contact the SMaHT Program via email for further information regarding this opportunity.

General Info

NIH SMaHT Program seeks technology development for somatic mutation detection and functional interpretation.

Agency

Department Of Health And Human Services → National Institutes Of HealthView Agency

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)View NAICS

Place of Performance

Not specified

Set-Aside

NONE

Documents

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Timeline

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUSA
Organization / Agency
Department Of Health And Human Services → National Institutes Of Health
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Office AddressUSA
Contacts
SMaHT Program
contact@example.gov

Full Description

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The purpose of the Somatic Mosaicism across Human Tissues (SMaHT) Network is to advance discovery of biological processes and disease mechanisms mediated by somatic mutations in human tissues. Since 2023, the program has generated multi-omic somatic mutation datasets from standardized human tissues spanning all three germ layers. Building on the Stage 1 foundation, the NIH intends to issue a Notice of Funding Opportunity (NOFO)supporting Stage 2 of the SMaHT Experimental and Computational Technology Development initiative. The Experimental and Computational Technology Development initiative supports multidisciplinary development, optimization, validation, benchmarking, and dissemination of rigorous, cost-effective technologies for somatic mutation detection and functional interpretation.

Awardees will collaborate with other SMaHT Stage 2 initiatives to incorporate validated technologies into production workflows, pipelines, data releases, and community resources.

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