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Somatic Mosaicism across Human Tissues (SMaHT) Program: Genome Characterization Centers (UM1 Clinical Trial Not Allowed)

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The National Institutes of Health, under the Department of Health and Human Services, is issuing a forecast for Stage 2 of the Somatic Mosaicism across Human Tissues (SMaHT) Genome Characterization Centers initiative. Building upon the multi-omic datasets established in Stage 1, this program aims to advance the understanding of biological processes and disease mechanisms driven by somatic mutations across various human tissues. The primary objective of the Stage 2 centers is to determine the functional consequences of somatic mutations within both healthy and clinically relevant tissue samples, specifically focusing on patients whose phenotypes are suspected to be driven by these mutations. This effort is designed to further characterize somatic mosaicism and its broader role in human biology and disease.

General Info

NIH Stage 2 SMaHT initiative studies functional consequences of somatic mutations in human tissues.

Agency

Department Of Health And Human Services → National Institutes Of HealthView Agency

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)View NAICS

Place of Performance

Not specified

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUSA
Organization / Agency
Department Of Health And Human Services → National Institutes Of Health
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Office AddressUSA
Contacts
SMaHT Program
contact@example.gov

Full Description

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The purpose of the Somatic Mosaicism across Human Tissues (SMaHT) Network is to advance the discovery of biological processes and disease mechanisms mediated by somatic mutations in human tissues. Since 2023, the program has generated multi-omic somatic mutation datasets from a standardized set of human tissues spanning all three germ layers. Building on the Stage 1 foundation, the NIH intends to issue a Notice of Funding Opportunity (NOFO) seeking support for Stage 2 of the SMaHT Genome Characterization Centers (GCCs) initiative.

The SMaHT Stage 2 GCCs will determine the functional consequences of somatic mutations in healthy and clinically relevant tissue samples, the latter comprising patients whose phenotype is suspected to be driven by somatic mutations. This work will support the SMaHT Network's efforts to characterize somatic mosaicism and its role in human biology and disease.

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