This Government Contract opportunity from Department Of Health And Human Services was posted on May 19, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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TCR Construct Optimization and Genetic Engineering

Closed

Federal

Submission Closed06/03/2026, 01:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

Active Opportunities Like This One

NAICS: 541715

New

Federal

Advanced Capability Research & Development

Missile Defense Agency (mda)

POSTED

DEADLINE

U.S. Army Contracting Command – Sierra Army Depot (ACC-SIAD) Organic Industrial Base (OIB) Modernization Commercial Solutions Opening (CSO)

Solicitation # W912GY-25-S-C001

The U.S. Army Contracting Command – Sierra Army Depot (ACC-SIAD) has issued Commercial Solutions Opening (CSO) solicitation W912GY-25-S-C001 to modernize its Organic Industrial Base (OIB). This initiative focuses on enhancing the speed of battle and force projection through the procurement of innovative commercial items, technologies, and services. Key priority areas include advanced manufacturing, connected digital enterprises, automation and robotics, digital twins, cybersecurity, and agile or flexible facilities. The program is structured around several continuously open Areas of Interest (AoI), which include logistics and inventory management modernization, airfield maintenance, energy and environmental management, and public-private partnerships. Authorized under DFARS Subpart 212.70 and 10 U.S.C. § 3458, this streamlined acquisition process is open to both traditional and non-traditional defense contractors. The solicitation remains open until June 30, 2030, utilizing a multi-phased evaluation process consisting of solution briefs, presentations or pitches, and commercial solution proposals. Awards are intended to be fixed-price contracts issued under FAR Part 12 Commercial Item Procedures. Eligible respondents must be registered in the System for Award Management (SAM) and the PIEE invoicing system. Specific requirements for individual needs, such as the procurement of a Roll Off Truck under AoI W912GY-26-S-C0001, are managed through separate technical specifications and submission deadlines.

W6QK Siad Contr Office

POSTED

DEADLINE

Synthetic Training Environment (STE) Virtual Software (VSW)

Solicitation # STE-VSW-26-0006

The Army Contracting Command - Aberdeen Proving Grounds Orlando Division, on behalf of the Capability Program Executive Simulation, Training, Test and Threat, is issuing a Call for Solutions for the Synthetic Training Environment Virtual Software program. This effort seeks a modernized virtual software ecosystem to achieve four primary operational outcomes: a doctrinal gate to live fire, a true combined arms environment, full mission command concurrency, and an open system architecture with published SDKs and APIs. The total combined value of all awarded lots is approximately 250 million dollars. The acquisition is structured around five capability lots, including Common Core Software and Simulation Application Software, with a phased selection process involving initial technical validation, down-selects, and demonstration pitches. The evaluation process prioritizes technical schedule, technical approach, and recent relevant experience from the last three years. A key requirement is the blind assessment of technical concepts to ensure objectivity, requiring offerors to genericize all identifying company information in their submissions. Technical solutions must demonstrate high commercial maturity, typically TRL 8 or 9, and adhere to strict security-by-design principles, including the delivery of Software Bill of Materials and alignment with RMF and FedRAMP authorizations. To prevent organizational conflicts of interest, any entity performing on Lot 5 is prohibited from participating in Lots 1, 2, or 4. The anticipated award date for the lots is November 13, 2026, following a rigorous schedule of industry days, solution submissions, and technical demonstrations.

POSTED

DEADLINE

Missile Defense Agency - Advanced Capability Concepts

Solicitation # HQ0860-25-S-C001

The Missile Defense Agency (MDA) has issued solicitation HQ0860-25-S-C001 for its Advanced Capability Concepts program, an ongoing opportunity open from May 9, 2025, to May 8, 2030. The agency seeks innovative concepts, scientific breakthroughs, and prototype demonstrations to enhance the robustness and effectiveness of all Missile Defense System elements. Key focus areas include kinetic and hypersonic defense, command and control battle management, integrated non-kinetic and electronic warfare, and disruptive technologies such as AI/ML, resilient networking, and advanced sensors. This is a two-step process where industry is invited to submit white papers on a rolling basis, which are then evaluated for potential negotiation and award. Submissions must follow strict formatting guidelines, including a 10-page limit for the combined executive summary and program description, and must include a Rough Order of Magnitude cost estimate and a program summary quad chart. Awards may be structured as either FAR-based procurement contracts or Other Transaction (OT) agreements, depending on the offeror's recommendation and eligibility. Evaluation is based on a trade-off process prioritizing technical achievement, research capabilities, and program management. Offerors must maintain active SAM.gov registration, disclose any organizational conflicts of interest, and comply with NIST SP 800-171 for safeguarding controlled unclassified information. Performance is centered in Huntsville, Alabama, though the agency emphasizes rapid development and compressed timelines for the transition of breakthroughs into acquisition programs.

Missile Defense Agency (mda)

POSTED

DEADLINE

R3PEATS Multi-Team Triangulation: Collaborative Cross-Method Approaches to Scientific Discovery (RM1)The R3PEATS Multi-Team Triangulation initiative, managed by the National Institutes of Health under the Department of Health and Human Services, focuses on collaborative cross-method approaches to scientific discovery. This program supports coordinated teams investigating central biomedical research questions using complementary populations, model systems, or methods. A primary objective is to enhance scientific excellence by identifying signal robustness and biological variability while integrating replication directly into the research design. This effort is part of the broader NIH Common Fund program dedicated to Rigor, Replicability, and Reproducibility to Promote Excellence, Accuracy, and Translation in Science. The opportunity is currently listed as a forecast with a posted date of September 11, 2026, and interested parties can contact the R3PEATS Program for further information.

National Institutes Of Health

POSTED

DEADLINE

R3PEATS Rigor Scholar Cohort Awards (K12)The R3PEATS Rigor Scholar Cohort Awards (K12) are offered by the National Institutes of Health under the Department of Health and Human Services. These awards are designed to support early-career researchers in enhancing their expertise in rigorous scientific practices, including randomization, blinding, preregistration, and transparent dissemination. This initiative is part of the broader NIH Common Fund program aimed at promoting excellence, accuracy, and translation in science. Participants will work within local and national cohorts to co-develop procedures and share knowledge, fostering the skills necessary to champion high-quality scientific practices through multi-institutional collaboration. This opportunity is currently listed as a forecast with a posted date of September 11, 2026, and inquiries can be directed to the R3PEATS Program.

National Institutes Of Health

POSTED

DEADLINE

R3PEATS Grassroots Rigor Projects: Individual Metascience and Individual Laboratory Capacity-Building (RP1)The National Institutes of Health, under the Department of Health and Human Services, is issuing a forecast for R3PEATS Grassroots Rigor Projects focusing on Individual Metascience and Individual Laboratory Capacity-Building. This initiative is part of the NIH Common Fund's broader program to promote excellence, accuracy, and translation in science by enhancing rigor, replicability, and reproducibility. The program supports two distinct project types designed to improve research practices. Metascience projects focus on the development and evaluation of infrastructure, metrics, guidelines, and tools to ensure high-quality research. Laboratory Capacity-Building projects assist labs in implementing new processes and techniques related to replicability while documenting the factors that impact research outcomes.

National Institutes Of Health

POSTED

DEADLINE

Climate Program Office (CPO) FY2026 Earth System Science and Services Partnership

Solicitation # NOAA-OAR-CPO-2026-33326

The Climate Program Office FY2026 Earth System Science and Services Partnership is a federal solicitation by the Department of Commerce NOAA to support research and activities aligned with understanding and predicting changes in the Earth's atmosphere, oceans, coasts, land, and ice. The program focuses on collaborative efforts involving numerical modeling, observations, monitoring, data impact evaluations, and stakeholder engagement to assess effects on ecosystems, weather, hazards, and infrastructure. Total available funding for this initiative is anticipated to be approximately 10 million dollars. Eligible applicants are limited to non-profit research institutions or academic institutions of higher learning that offer doctoral degrees in NOAA-related sciences, though multi-institution applications are not permitted. Interested parties must submit their responses by October 26, 2026.

Department Of Commerce Noaa

POSTED

DEADLINE

Specialized HPC Support (AI/ML & Quantum)

W2R2 USA Engr R & D Ctr

POSTED

DEADLINE

Physiological and Cognitive Testing Services

NASA Shared Services Center

POSTED

DEADLINE

RNA-Seq Bioinformatics Analysis

Office Of Acquisiton Grants

POSTED

DEADLINE

Industrial Security Technologies, Strategy, and Research (ISTS/ISSR)

Defense Ci And Security Agency

POSTED

1 day ago

DEADLINE

in 10 days

AI Contract Overview

This contract involves the design and optimization of the A11 HERV-E T-cell receptor construct, aiming to improve its antigen specificity, binding affinity, and T-cell activation capabilities. The work includes genetic engineering tasks such as codon optimization and vector design, alongside comprehensive in vitro validation to ensure the enhanced functionality of the T-cell receptor. The project is focused on advancing the efficacy of this receptor construct for potential therapeutic applications. The subcontract is issued by the National Institutes of Health under the Department of Health and Human Services, with the place of performance located in Bethesda. The contract falls under the NAICS code 541715, which pertains to research and development in the physical, engineering, and life sciences. Proposals for this work were to be submitted by June 3, 2026, following the solicitation posted on May 19, 2026.

General Info

Design and optimize A11 HERV-E T-cell receptor for improved specificity and activation, with in vitro validation.

Agency

Department Of Health And Human Services → National Institutes Of Health OlaoView Agency

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)View NAICS

Place of Performance

Bethesda, MD, 20892, USA

Set-Aside

NONE

Documents

This scope was carved out of 75N98026Q00392.

The full solicitation package (1 document), including the RFP, is on the prime solicitation, not on this scope.

View the prime solicitation

Modification to the A11 HERV-E TCR and T cell product to improve the therapeutic efficacy for ccRCC patients.

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Timeline

PhaseClosed

PostedMay 19

subcontract

Response DeadlineJun 3

Deadline has passed

Submission Closed

06/03/2026, 01:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → National Institutes Of Health Olao

ContactsNo contacts available

OfficeN/A

Organization / Agency

Department Of Health And Human Services → National Institutes Of Health Olao

View Agency Profile

Office AddressN/A

ContactsNo contact information available

Full Description

Design and optimization of the A11 HERV-E T-cell receptor construct to enhance antigen specificity, binding affinity, and T-cell activation, including codon optimization, vector design, and in vitro validation.