This Pre-Solicitation opportunity from Department Of Defense was posted on March 25, 2025. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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N00019-27-RFPREQ-JSFAV-0022Federal

Submission Closed04/15/2025, 09:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

Active Opportunities Like This One

NAICS: 541715

New

Grant

Notice of Change in Application Due Date for NHLBI NOFOs PAR-25-025 and PAR-25-026

Solicitation # NOT-HL-27-002

This notice announces updates to the key dates for two National Heart, Lung, and Blood Institute funding opportunities, PAR-25-025 and PAR-25-026. These opportunities support early phase clinical trials for therapeutics and diagnostics related to heart, lung, and blood disorders. The primary purpose of the update is to add one additional receipt date for new applications as well as resubmission and revision applications. As a result of these changes, the expiration date for both notices of funding opportunity has been extended to February 4, 2027. A new application deadline has been established for February 3, 2027, with a corresponding earliest start date of December 2027. All other terms, conditions, and requirements of the original funding opportunities remain unchanged.

National Heart, Lung, And Blood Institute

POSTED

DEADLINE

Notice of Change in Application Due Date for PAR-25-032 "NHLBI Clinical Trial Pilot Studies (R34 Clinical Trial Optional)"

Solicitation # NOT-HL-27-003

The National Heart, Lung, and Blood Institute has issued a notice regarding changes to the Notice of Funding Opportunity PAR-25-032 for Clinical Trial Pilot Studies. The primary purpose of this update is to extend the availability of the funding opportunity by adding an additional receipt date for new applications as well as resubmission and revision applications. As a result of these changes, the expiration date for the NOFO has been moved to March 17, 2027. All other terms, conditions, and requirements of the original solicitation remain unchanged. Applicants are reminded that all submissions must be received by 5:00 PM local time of the applicant organization.

National Heart, Lung, And Blood Institute

POSTED

DEADLINE

Notice of NHLBI Withdrawal from Participation in PA-25-305 "NIH Research Project Grant (Parent R01 Clinical Trial Required)"

Solicitation # NOT-HL-27-001

This notice announces that the National Heart, Lung, and Blood Institute (NHLBI) will withdraw its participation from the NIH Research Project Grant PA-25-305, which requires clinical trials. This withdrawal becomes effective for all application due dates occurring after July 5, 2026. While the NHLBI is exiting this specific funding opportunity, all other participating NIH organizations and institutes remain involved. No other terms or conditions of the original notice of funding opportunity have been changed.

National Heart, Lung, And Blood Institute

POSTED

DEADLINE

Notice of NIDCR Participation in PA-25-302, NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed)

Solicitation # NOT-DE-27-001

The National Institute of Dental and Craniofacial Research (NIDCR) has announced its participation in the NIH Small Research Grant Program, specifically under the Notice of Funding Opportunity PA-25-302. This program, which does not allow clinical trials, is effective for application due dates on or after February 16, 2027. The NIDCR joins a wide array of other NIH institutes and centers, including the National Cancer Institute and the National Center for Advancing Translational Sciences, in offering this funding opportunity. All submitted applications must align with the specific missions of the participating Institutes or Centers. Additionally, the Office of Data Science Strategy may provide co-funding for assigned applications. While the list of participating organizations and associated assistance listing numbers has been updated to include the NIDCR, all other terms and conditions of the original funding opportunity remain unchanged.

National Institute Of Dental And Craniofacial Research

POSTED

DEADLINE

Director's Fellowship Research SupportThe Director's Fellowship Research Support is a subcontract opportunity with the Defense Advanced Research Projects Agency under the Department of Defense. This initiative seeks high-level academic research expertise to support prime contractors on DARPA projects, specifically focusing on advanced research in plasma physics, thermomechanical resilience, and AI/ML. Work is to be conducted using institutional or university research facilities, with expected deliverables including technical contributions, academic publications, and fellowship research outputs. Qualified candidates must hold a PhD or an equivalent advanced degree and meet all established DARPA fellowship criteria. The solicitation was posted on October 20, 2026, and requires responses by January 13, 2027. This effort falls under NAICS code 541715, emphasizing the specialized nature of the scientific research required for these defense initiatives.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

Scalable Thermomechanical Resilience ResearchThe Scalable Thermomechanical Resilience Research subcontract, issued by the Defense Advanced Research Projects Agency under the Department of Defense, focuses on investigating fundamental mechanisms to improve the thermomechanical resilience of materials and devices. The project involves analyzing material behavior under thermal and mechanical stress through the use of stress-testing rigs, thermal imaging, and SEM/TEM characterization. The primary goal is to provide prime contractors with critical material specifications, performance reports, and resilience models. Qualified candidates must possess specialized expertise in Thermodynamics, Mechanical Engineering, or Materials Science. This opportunity was posted on October 20, 2026, with a response deadline of January 13, 2027. The work falls under NAICS code 541715, emphasizing the research and development nature of the technical requirements.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

Plasma Dynamic Heterostructure Layer ResearchThis subcontract, titled Plasma Dynamic Heterostructure Layer Research, supports prime contractors on DARPA research projects within the Department of Defense. The scope of work involves the research and development of plasma as a dynamic heterostructure layer for electron emission. The selected party will be responsible for designing and testing these layers and analyzing emission properties utilizing spectroscopy tools, plasma generation equipment, and vacuum chambers. The project requires specialized expertise in Quantum Electronics, Materials Science, or Plasma Physics. Key deliverables include prototype plasma layer configurations, technical reports, and comprehensive experimental data. This opportunity was posted on October 20, 2026, with a response deadline of January 13, 2027, falling under NAICS code 541715.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

Numerical Analysis of Iterative Prompt Engineering and AlignmentThis subcontract for the Defense Advanced Research Projects Agency focuses on the numerical analysis and research of iterative prompt engineering and Large Language Model alignment. The selected provider will support prime contractors on DARPA research projects by developing frameworks to quantify alignment effectiveness, utilizing high-performance computing clusters and specialized LLM frameworks. Key deliverables for the engagement include numerical models, alignment code, and detailed research reports. Qualified candidates must possess an advanced degree in Artificial Intelligence, Mathematics, or Computer Science. The opportunity was posted on October 20, 2026, with a response deadline of January 13, 2027. The work falls under NAICS code 541715, emphasizing the technical and scientific research nature of the requirements.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

Space & Ground Systems Engineering (V&V and Troubleshooting)This subcontract opportunity with the Department of the Air Force focuses on providing specialized systems engineering support for prime contractors working on Space Rapid Capabilities Office projects. The scope of work centers on the verification and validation of interface requirements, hardware integration and testing, and the execution of on-orbit troubleshooting for payloads on host vehicles. To ensure mission success, the contractor will utilize integration test beds and adhere to strict V&V standards. Key deliverables for this effort include comprehensive V&V reports, detailed integration test results, and anomaly resolution reports. The work is designated under NAICS code 541715 and is slated for performance in Dayton. Interested parties must submit their responses by the deadline of November 4, 2026.

Department Of The Air Force

POSTED

DEADLINE

Custom Synthesis of SYK Inhibitors (S1115 and S1213)This subcontract involves the custom chemical synthesis and scale-up of lead Spleen Tyrosine Kinase inhibitors, specifically compounds S1115 and S1213, to support NIH/NHLBI research projects. The selected contractor will utilize organic chemistry laboratories and scale-up reactors to optimize these compounds while strictly adhering to medicinal chemistry synthesis protocols and established laboratory safety standards. The primary deliverable for this engagement is the production of 3 to 5 grams of each synthesized compound. Managed under the Department of Health and Human Services for the National Institutes of Health, the project falls under NAICS code 541715, with a response deadline set for November 4, 2026.

National Institutes Of Health Olao

POSTED

DEADLINE

Academic and Research PartnersThe Academic and Research Partners subcontract supports the USMC Department of Defense by providing foundational research and conceptual development for prime contractors on PM TRASYS training systems projects. The scope of work involves identifying innovative commercial concepts, developing technical briefs, and validating technology maturity levels. Eligible participants must operate as academic institutions or Non-Traditional Defense Contractors. Key deliverables for this engagement include research reports, technical white papers, and validated concept demonstrations. The contract is categorized under NAICS code 541715 and remains open for responses until October 19, 2031.

POSTED

DEADLINE

Commercial Technology Providers (General AoI)This subcontract opportunity, titled Commercial Technology Providers (General AoI), seeks partners to supply and integrate mature or emerging commercial technologies for prime contractors supporting PM TRASYS training systems projects. The scope of work involves executing agile development activities, pilots, and concept demonstrations designed to address specific training gaps. Selected providers must deliver functional commercial solutions or prototypes that are fully integrated into Department of the Army or Defense systems. Managed under the USMC and Department of Defense, the contract emphasizes the need for long-term sustainability and integration readiness. The performance period extends through October 19, 2031, with the primary focus falling under NAICS code 541715 for research and development in the physical, engineering, and life sciences.

USMC

POSTED

1 day ago

DEADLINE

in almost 5 years

General Info

Agency

Department Of Defense → Naval Air Systems Command

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Fort Worth, TX, 76108, USA

Set-Aside

NONE

Documents

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Timeline

PhaseClosed

PostedMar 25

Presolicitation

Response DeadlineApr 15

Deadline has passed

Submission Closed

04/15/2025, 09:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Defense → Naval Air Systems Command

Contacts2 people available

OfficePATUXENT RIVER, MD, 20670-5000, USA

Organization / AgencyDepartment Of Defense → Naval Air Systems Command

Office AddressPATUXENT RIVER, MD, 20670-5000, USA

Contacts

Edwin Wilbert

contact@example.gov

Gina M. Bailey

contact@example.gov

Full Description

The F-35 - Lightning II Program Office intends to solicit offers for multiple contract actions from Lockheed Martin Aeronautics Company, Fort Worth, TX, for incremental F-35 Follow on Modernization Block 4 and subsequent Block 5 upgrades. This includes all developmental efforts necessary to deliver Block 4 and Block 5 upgrades; assessments and evaluations of the F-35 Air System's ability to meet future operational requirements; systems engineering and design; procurement and support for prototype construction; upgrade of existing hardware and test assets; correction of air system deficiencies; comprehensive test and evaluation to demonstrate the system integration, interoperability, supportability, safety, and utility; and acquisition of technical, administrative, and financial data. This acquisition is being pursued on a sole source basis under the statutory authority of 10 U.S.C. 2304(c)(1), as implemented by Federal Acquisition Regulation (FAR) 6.302-1, only one responsible source and no other supplies or services will satisfy agency requirements. This notice of intent is not a request for competitive proposals; however, any capability statements, proposals, or quotations received within fifteen (15) days after the date of publication of this synopsis will be considered by the Government. Lockheed Martin Aeronautics Company is the sole designer, developer, manufacturer and integrator of the F-35 aircraft and the related equipment. Lockheed Martin alone has the experience, special skills, proprietary technical documentation, software/algorithms, and technical expertise required to furnish the supplies and services within the required timeframe. Accordingly, Lockheed Martin is the only known qualified, responsible source that can fulfill the requirements specified herein. Subcontracting opportunities may be available and should be sought with Lockheed Martin through Sean Lightcap, 817-584-1276. This notice is not a commitment by the Government to issue a solicitation, make an award (or awards), or be responsible for any cost incurred by interested parties prior to award of a contract for the effort described above. Information provided herein is subject to change. The data associated with the F-35 JPO is export controlled and is not available to foreign sources or representatives.