This Government Contract opportunity from Department Of Health And Human Services was posted on July 27, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

Top

Whole-Brain Light-Sheet Microscopy Imaging

Closed

Federal

Submission Closed08/05/2026, 01:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

Active Opportunities Like This One

NAICS: 541715

New

Federal

Machine Learning & Predictive Analytics EngineeringThis subcontract, titled Machine Learning and Predictive Analytics Engineering, is issued by the Naval Air Systems Command under the Department of Defense. The project focuses on the development and deployment of production-ready machine learning algorithms to support prime contractors on F-35 Joint Program Office projects. Key objectives include creating solutions for supply-chain optimization, readiness forecasting, and predictive maintenance, utilizing ML engineering pipelines within AWS and Azure GovCloud architectures. The scope of work involves managing CI/CD/CT pipelines and delivering validated source code and predictive models. Due to the nature of the work, an active Top Secret clearance is required. The performance location for this contract is Arlington, Virginia, with a response deadline set for November 10, 2026.

Naval Air Systems Command

POSTED

DEADLINE

Digital Biomarker & Computational Modeling DevelopmentThis subcontract focuses on the development and validation of objective digital biomarkers and computational models to support prime contractors within the Defense Health Agency Alzheimer’s Research Program. The scope of work involves utilizing high-performance computing and AI/ML software frameworks to create algorithms for early disease detection and predictive models for disease forecasting. The project requires strict adherence to HIPAA compliance and FDA software validation standards to ensure the integrity and security of the delivered models. Performance will take place in Frederick, Maryland, with the primary objective of delivering validated digital biomarkers and predictive tools to the Department of Defense.

Defense Health Agency

POSTED

DEADLINE

TBI & Psychological Health Research Services

Defense Health Agency

POSTED

DEADLINE

Space Power and Reactor Capabilities (SPARC) - Sources Sought Notice

Solicitation # 80GRC026R0009_PS

NASA Glenn Research Center

POSTED

DEADLINE

Atomically Precise Molecules (APM)

Solicitation # DARPA-PS-26-141

The Atomically Precise Molecules (APM) program, solicitation DARPA-PS-26-141, is a 36-month initiative by the DARPA Multi X Office seeking innovative synthesis techniques for programmable precision polymers (PPPs) and nonlinear optical (NLO) materials. The program aims to develop scalable materials with strictly controlled monomer sequences and compositions, culminating in a prototype NLO material integrated into a government-provided electro-optic modulator capable of achieving greater than 1THz modulation. The effort is structured in two phases, with Phase I lasting 12 months and focusing on synthesis capabilities. Research limited to inorganic materials or incremental improvements to existing state-of-the-art practices is specifically excluded. Awards will be issued as Other Transaction for Prototype Agreements, with payments processed through the Wide Area Workflow system based on a schedule of milestones. Proposals are due by December 18, 2026, via the Broad Agency Announcement Tool and must include technical, management, and pricing volumes. Eligibility is restricted to U.S. organizations, and all performers must comply with CMMC Level 2 self-certification and NIST SP 800-171 standards for safeguarding Controlled Unclassified Information. Evaluation will be based on technical approach, relevance to the DARPA mission, budget realism, and the capability to transition the technology to military or commercial sectors.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

Sole Source to L3Harris ForceX, Inc | VAMPIRE Spares

Solicitation # SPRRA2-27-R-SP05

Al DLA Aviation At Huntsville

POSTED

DEADLINE

A-- TREDS III supporting DOE, NNSA and NFO

Solicitation # 89233127RNA000340

Nnsa Non-Mo Cntrctng Operations Division

POSTED

DEADLINE

Request for Proposal (RFP) - Resilient Missile Warning Tracking (RMWT) Low Earth Orbit (LEO) Ground Entry Points (GEPs)

Solicitation # FA240126R0003

The Space Development Agency is soliciting proposals under solicitation FA240126R0003 for the Resilient Missile Warning Tracking Low Earth Orbit Ground Entry Points effort. This acquisition is structured as an Indefinite Delivery Indefinite Quantity contract with a ceiling of 369 million dollars, covering the development, integration, test, operations, and maintenance of Tranche 3 Ground Entry Points at multiple globally dispersed locations. The scope of work encompasses civil engineering from detailed design through construction, the procurement and installation of communications shelters, antennas, optical terminals, and networking equipment, as well as the development of Ground Support Equipment and Auxiliary Development Units. The contract includes an ordering period from March 31, 2027, to September 30, 2031, with option periods extending through September 30, 2035. Award will be determined using a best value tradeoff process where technical, management, and past performance factors are combined and considered significantly more important than price. The technical evaluation focuses on the understanding of requirements, feasibility of approach, and scalability, while management is assessed based on project and schedule management, subcontractor oversight, and security handling. Proposals must be submitted in seven volumes via the DoD Secure Access File Exchange by 4:00 PM Eastern Time on November 23, 2026. Large business primes are required to meet a minimum quantitative requirement of 5 percent small business participation. The contract utilizes a mix of Firm Fixed Price for primary labor and materials and Cost Reimbursable arrangements for other direct costs and travel.

FA2401 Space Development Agency Sda

POSTED

DEADLINE

Pioneering Aerospace Capabilities, Engineering and Research

Solicitation # FA2391-23-S-2403

The Pioneering Aerospace Capabilities, Engineering and Research (PACER) program, under solicitation FA2391-23-S-2403, is a comprehensive Broad Agency Announcement issued by the Air Force Research Laboratory (AFRL) Aerospace Systems Directorate. This open, two-step solicitation is designed to fund research and development efforts that mature novel aerospace concepts and technologies to appropriate technology readiness levels, specifically targeting transformative capabilities for the warfighter. The program encompasses a wide array of specialized calls, including efforts for hypersonic weapon concepts (HAMWC), automated air-to-air refueling (CRONUS), advanced propulsion and power systems (SNAPP, AEPO, MSIPPT, HITEMP, INNATE), and multidisciplinary design and structures (MASTR, VOLARE, CC DROIDS). The acquisition process typically involves an initial white paper submission followed by full proposals from selected offerors, though some calls utilize a one-step process. Awards may take the form of contracts or assistance instruments, with anticipated types including Cost Plus Fixed Fee (CPFF), Firm-Fixed-Price (FFP), and IDIQ task orders. Due to the sensitive nature of the research, strict security protocols are enforced, requiring offerors to comply with AFRLI 61-113 for Science and Technology Protection and meet CMMC Level 2 and NIST SP 800-171 standards to access Controlled Unclassified Information (CUI). Proposals are evaluated based on the uniqueness and innovation of the approach, understanding of scope, technical soundness, and transition potential, with cost realism serving as a secondary substantial factor.

FA2391 USAF Afmc Afrl Pzl Afrl Rqkp

POSTED

DEADLINE

Technical Research, Engineering, and Development Services (TREDS) III supportin

Solicitation # 89233127RNA000340

The Technical Research, Engineering, and Development Services (TREDS) III contract, solicitation number 89233127RNA000340, is a cost-reimbursement no-fee acquisition managed by the National Nuclear Security Administration (NNSA) for the Department of Energy. The contract provides multidisciplinary technical research, engineering, and operational support focusing on nuclear nonproliferation, cultural resources management, community environmental monitoring, and hydrologic science. Work is performed across the Nevada National Security Site, the Nevada Test and Training Range, and over 24 monitoring locations in Nevada, Utah, and California. The total estimated value exceeds 89 million dollars over a ten-year period of performance, which consists of a two-year base period and four subsequent two-year options, with a potential six-month extension per FAR 52.217-8. The government is currently pursuing a proposed sole-source award to the Nevada System of Higher Education, doing business as the Desert Research Institute, under NAICS 541715. However, a Notice of Intent has been issued to determine if a competitive procurement is necessary based on the receipt of capability statements. Key requirements for any provider include active organizational Facility Security Clearances and personnel with DOE Q or DoW Top Secret clearances. Additionally, the contractor must demonstrate scientific independence and trust with state regulatory authorities, such as the Nevada Division of Environmental Protection, and adhere to strict worker safety and security requirements under DEAR 952.204-2 and NNS-H-1019.

Contracting Operations Division

POSTED

DEADLINE

Statistical ExpertiseThis small business set-aside subcontract, titled Statistical Expertise, supports prime contractors on NIH/NHGRI projects within the Department of Health and Human Services. The scope of work involves providing advanced statistical analysis and design for clinical research protocols, specifically requiring expertise in SAS or R for statistical programming, sample size calculations, and the interpretation of trial results. Key deliverables include validated statistical outputs, final analysis reports, and Statistical Analysis Plans. The performance of this contract takes place in Bethesda and is subject to strict HIPAA compliance, necessitating a mandatory Business Associate Agreement. Interested parties should note the response deadline of November 13, 2026, and the classification under NAICS code 541715.

National Institutes Of Health Olao

POSTED

DEADLINE

Protocol Monitoring and Data Management SupportThis subcontract opportunity, titled Protocol Monitoring and Data Management Support, involves providing clinical trial protocol monitoring and research data management for prime contractors on NIH/NHGRI clinical research projects. The scope of work includes monitoring clinical research protocols, managing data services, and developing transition and startup documentation to deliver validated research datasets and monitored protocol reports. Performance will take place in Bethesda, and the project is categorized under NAICS code 541715. The contract is designated as a Total Small Business Set Aside for the National Institutes of Health under the Department of Health and Human Services. To ensure regulatory compliance, the selected provider must adhere to NIH ICO Information Security and Privacy certifications and execute a Business Associate Agreement for HIPAA compliance. Responses are due by November 13, 2026.

National Institutes Of Health Olao

POSTED

2 days ago

DEADLINE

in 16 days

AI Contract Overview

This contract seeks to perform high-resolution 3D fluorescence imaging of cleared whole mouse brains using light-sheet microscopy to capture detailed neural activity patterns. The work involves advanced imaging techniques to visualize and analyze brain-wide neural circuits with precision, requiring specialized equipment and expertise in optical clearing, fluorescence labeling, and microscopy. The project is structured as a subcontract under the National Institutes of Health, operating through the Department of Health and Human Services, with performance located in Bethesda, Maryland, and a NAICS code of 541715 indicating it falls under research and development in the physical, engineering, and life sciences. The solicitation was posted on July 27, 2026, with a response deadline of August 5, 2026, at 1:00 PM Eastern Time. The contract does not specify a set-aside type or organizational preferences, and no point of contact information is provided in the data. Interested parties must submit proposals prior to the deadline to be considered for award, and the performance location is fixed at Bethesda, ensuring delivery of imaging services and related data analysis within this designated federal research hub. All work must align with the scientific objectives of capturing comprehensive neural activity patterns across entire brains with high spatial and temporal resolution.