Whole-Brain Light-Sheet Microscopy Imaging

This contract seeks to perform high-resolution 3D fluorescence imaging of cleared whole mouse brains using light-sheet microscopy to capture detailed neural activity patterns. The work involves advanced imaging techniques to visualize and analyze brain-wide neural circuits with precision, requiring specialized equipment and expertise in optical clearing, fluorescence labeling, and microscopy. The project is structured as a subcontract under the National Institutes of Health, operating through the Department of Health and Human Services, with performance located in Bethesda, Maryland, and a NAICS code of 541715 indicating it falls under research and development in the physical, engineering, and life sciences. The solicitation was posted on July 27, 2026, with a response deadline of August 5, 2026, at 1:00 PM Eastern Time. The contract does not specify a set-aside type or organizational preferences, and no point of contact information is provided in the data. Interested parties must submit proposals prior to the deadline to be considered for award, and the performance location is fixed at Bethesda, ensuring delivery of imaging services and related data analysis within this designated federal research hub. All work must align with the scientific objectives of capturing comprehensive neural activity patterns across entire brains with high spatial and temporal resolution.