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DESIGN-ZYME LLC

UEI: RM33XDX5RRG4CAGE: 7KSG8

DESIGN-ZYME LLC is a federal contractor, registered under UEI RM33XDX5RRG4 and CAGE code 7KSG8. It has been awarded $4,778,819 in federal contracts. Primary work spans Research and Development in Biotechnology (except Nanobiotechnology), Unknown NAICS, and Research and Development in Biotechnology. Top awarding agencies include Department Of Health And Human Services and Department Of Defense.

Contact Information

Registration and classification details

Emailcontact@company.com

Phone+1 (555) 000-0000

Websitehttp://design-zyme.com

Address123 Main St, City, ST 12345

Registration

UEI Code

RM33XDX5RRG4

CAGE Code

7KSG8

Entity Structure

Corporate Entity (Not Tax Exempt)

Established

N/A

Business Classifications

For Profit OrganizationLimited Liability Company

NAICS Codes

541714Research and Development in Biotechnology (except Nanobiotechnology)(Primary)

Federal Contracting Overview

Award totals, agency breakdown, NAICS distribution, and geographic footprint.

AI Capability Profile

DESIGN-ZYME LLC specializes in the design and development of novel biotechnological adjuvants for next-generation vaccine platforms, with a focused expertise in covalent chemistry applied to polysaccharide-based immunomodulators. Their technical capabilities center on the synthesis and characterizat...

Key Performance Metrics

Awards Count

6

All time

Active

1

Currently performing

Completed

5

Past period of performance

Total Awards

All time

Contracts

Prime · all time

Subcontracts

Sub · all time

Grants

Prime · all time

Subgrants

Sub · all time

Award Analytics & Distribution

Awards by Agency

Department Of Health And Human Services$4.0M84.3%Department Of Defense$750.0K15.7%

Awards by NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)$3.0M62.8%

- Unknown NAICS$1.0M21.5%

541711 - Research and Development in Biotechnology$750.0K15.7%

Awards by Agency Over Time

Awards by Place of Performance

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U.S. Army Long Range Precision Munition Launched Effects Medium Range-Lethal Prototype Integration and Qualification

Solicitation # 11e09f87-099d-4282-abc4-f6a4ce589397

Department Of Defense

POSTED

about 19 hours ago

DEADLINE

Health & Life Sciences Data ProviderThis subcontract opportunity with the Government of Canada seeks a Health and Life Sciences Data Provider to supply medical datasets and health-related information products. The selected provider will support prime contractors on Public Services and Procurement Canada projects by delivering pharmaceutical data, healthcare statistics, and clinical research information, as well as specialized life sciences reports. Interested parties must be capable of entering into a Provider’s Master License Agreement to facilitate the delivery of these datasets. The solicitation is open for responses until March 31, 2027, with the place of performance located within Canada.

Government of Canada / Gouvernement du Canada

POSTED

about 21 hours ago

DEADLINE

Senior Advisor for Neurotherapeutic Network (Small Molecules)The Senior Advisor for Neurotherapeutic Network (Small Molecules) is a small business set-aside subcontract through the Department of Health and Human Services Omas Strategic Buying Center. The selected consultant will provide executive-level subject matter expertise to prime contractors supporting NIH NINDS Blueprint Neurotherapeutic Network projects. Primary responsibilities include reviewing program operations, offering strategic recommendations for pharmacology-related trials, and leading drug discovery teams focused on small molecules for nervous system conditions. Qualified candidates must possess a PhD in Pharmacology, an MD, or an advanced degree in Organic Chemistry. The role requires the delivery of high-level technical reports, detailed scientific analyses, and formal recommendations to meet project milestones. This opportunity was posted on October 28, 2026, with a response deadline of November 5, 2026, falling under NAICS code 541714.

Omas Strategic Buying Center - Professional Services

POSTED

about 24 hours ago

DEADLINE

High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)

Solicitation # DARPA-PA-27-01

The High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE) program, solicited by the DARPA Biological Technologies Office under DARPA-PA-27-01, seeks to develop an in-silico capability for mapping all protein-protein interactions. The primary objective is to create a comprehensive human interactome hypercatalog capturing over 10 million new interactions, shifting from static biomarkers to dynamic, context-aware interactomes. The utility of this capability will be demonstrated by identifying novel diagnostic and therapeutic targets for traumatic brain injury. Awards will be issued as Other Transaction (OT) for Research agreements with fixed, payable milestones. The program is structured in two phases, with Phase 1 estimated at 12 months and Phase 2 anticipated at 18 months, though current awards are limited to Phase 1. Proposers, including large and small businesses, universities, and research institutions, must submit a maximum six-page unclassified abstract via the Broad Agency Announcement Tool by November 5, 2026, to be considered for an Oral Proposal Package due December 11, 2026. Evaluation is based on technical comprehension, technical ability, and the realism of the cost rough order of magnitude. Prime proposers must be registered in the System for Award Management and demonstrate CMMC Level 1 compliance. Performance will be managed through a Task Description Document and a milestone-based payment schedule, with invoicing processed through the Wide Area Workflow system. Security requirements include the Fundamental Research Risk-Based Security Review Process for all senior and key personnel.

Defense Advanced Research Projects Agcy

POSTED

about 24 hours ago

DEADLINE

AIR FORCE CRYPTOLOGIC OFFICE COMMERCIAL SOLUTIONS OPENING

Solicitation # FA7037-21-S-C001

The Air Force Cryptologic Office (AFCO) Cyberspace Intelligence Surveillance and Reconnaissance and Multi-Domain Innovation Division is soliciting innovative commercial capabilities through Commercial Solutions Opening FA7037-21-S-C001. The agency is seeking mature technologies and innovative services in Electromagnetic Warfare, Information Operations, and electromagnetic digital communications, with a specific goal of achieving a field demonstration within one year. The procurement process is divided into two phases: Phase I requires the submission of a quad chart and a white paper, while Phase II consists of full proposals by invitation only. Awards may be issued as traditional contracts or Other Transactions (OT), with potential funding ranging from 50,000 dollars to 50 million dollars over a period of performance lasting between one and five years. The evaluation process is based on technical merit, importance to agency programs, and fund availability, utilizing peer or scientific review to select offerors. Successful projects are expected to follow a structure of base period tasks to demonstrate feasibility, followed by option tasks for design, fabrication, testing, and evaluation. Because the work supports DoD ISR-Cyber capabilities, offerors must possess the necessary personnel and facility security clearances to handle classified work independently. All acquired technologies are treated as commercial items under 10 USC 3458 and DFARS 212.70. Submissions are managed by Carissa Heuertz, and the performance location is identified as San Antonio, Texas.

Department Of Defense

POSTED

about 24 hours ago

DEADLINE

Pharmacology and Pain Drug Development SMEThis subcontract opportunity through the Department of Health and Human Services Omas Strategic Buying Center seeks a subject matter expert in pharmacology and pain to support prime contractors on NIH HEAL Initiative projects. The selected expert will provide executive-level guidance on small molecule and biologic therapeutics, focusing on drug discovery and pharmacology-related trials for nervous system conditions. Key responsibilities include performing strategic programmatic reviews, evaluating milestones, and providing mentorship. The role requires the delivery of strategic recommendations and milestone evaluations through formal committee reports. Performance will take place in Bethesda, and the opportunity is categorized under NAICS code 541714. Interested parties should note the response deadline of November 3, 2026.

Omas Strategic Buying Center - Professional Services

POSTED

DEADLINE

Precision Prevention & Biological Pathway ResearchThe Precision Prevention and Biological Pathway Research subcontract supports prime contractors on Defense Health Agency Alzheimer’s Research Program projects. The primary objective is to conduct research linking service-related exposures to AD/ADRD biological pathways by quantifying military-relevant risk factors. This technical work involves the use of proteomics tools and genomic sequencing to map these biological pathways, culminating in the delivery of detailed research reports and data. Performance of this contract takes place in Frederick, Maryland, under NAICS code 541714. Due to the nature of the study, the contractor must obtain IRB approval and maintain all necessary Human Subjects Research certifications. Interested parties should note the response deadline of December 4, 2026.

Defense Health Agency

POSTED

DEADLINE

in about 1 month

Blood-Based Biomarker Validation & ScalingThis subcontract focuses on the validation and scaling of blood-based biomarkers to support prime contractors within the Defense Health Agency Alzheimer’s Research Program. The scope of work involves performing detailed laboratory analysis of blood samples, validating the sensitivity and specificity of assays, and establishing scalable testing protocols. These operations must utilize Simoa equipment and biobanking systems while adhering strictly to GLP standards and maintaining CLIA certification. The project is managed under the Department of Defense and is centered in Frederick, Maryland. The primary objective is the delivery of validated, scalable biomarker assays and protocols to advance research goals. Interested parties should note the response deadline of December 4, 2026, and the classification of the work under NAICS code 541714.

Defense Health Agency

POSTED

DEADLINE

in about 1 month

RFI Alzheimer’s Research Program (AZRP) Public

Solicitation # HT9427RFI2027AZRP

The Defense Health Agency, through the Congressionally Directed Medical Research Programs, has issued a Request for Information under solicitation number HT9427RFI2027AZRP to gather strategic feedback for the fiscal year 2027 Alzheimer’s Research Program. The primary objective is to identify research focus areas and funding opportunities aimed at mitigating the impact of Alzheimer's and related dementias, specifically those associated with traumatic brain injury, military service, and diverse risks. The program seeks to improve the quality of life for Service Members, Veterans, and their families by funding solution-oriented research, including the development of digital and blood-based biomarkers for early diagnosis and the creation of precision prevention strategies. This action is strictly for information and planning purposes and does not constitute a formal solicitation, request for proposals, or request for quotations. No contracts will be awarded based on this announcement, and FY27 funds have not yet been appropriated. Interested parties from academia, industry, non-profit organizations, and federal agencies are invited to provide feedback via Survey Monkey by December 4, 2026. Respondents are cautioned not to submit proprietary or sensitive information through the survey portal as it cannot be protected. The effort is categorized under NAICS code 541714 and is managed by the Department of Defense in Fort Detrick, Maryland.

Defense Health Agency

POSTED

DEADLINE

in about 1 month

Traumatic Brain Injury and Psychological Health Research Program Public Request for Information

Solicitation # HT9427RFI2027TBIPHRP

The Defense Health Agency, under the Department of Defense and the Congressionally Directed Medical Research Programs, has issued a Request for Information under solicitation number HT9427RFI2027TBIPHRP. This action is strictly for strategic planning and is not a formal solicitation, request for proposals, or request for quotations. The primary objective is to gather feedback from academia, industry, non-profit organizations, and the public to inform the research focus areas and funding opportunities for the fiscal year 2027 Traumatic Brain Injury and Psychological Health Research Program. The program aims to optimize the prevention, assessment, and treatment of psychological health conditions and traumatic brain injuries to benefit Service Members, Veterans, and the general public. Interested parties are asked to provide input on research gaps and funding priorities, specifically regarding the prevention, screening, diagnosis, and treatment of these conditions. Responses must be submitted via Survey Monkey by December 11, 2026. Because the government cannot protect proprietary or sensitive information submitted through the survey platform, such data should not be included. This inquiry does not commit the program to incorporating the feedback into future funding opportunities, and no contract will be awarded based on this specific announcement. All inquiries regarding this RFI should be directed to Patrick M. Younkins.

Defense Health Agency

POSTED

DEADLINE

in about 1 month

Request for Proposals (RFP) - BARDA Vaccine Medical Countermeasures for Pandemic Influenza Preparedness & Response

Solicitation # 75A50126R00001_RFP_NPIVS_27

The Biomedical Advanced Research and Development Authority (BARDA) is soliciting proposals for the Vaccine Medical Countermeasures for Pandemic Influenza Preparedness and Response Program. The objective is to maintain a permanent readiness posture against high-threat influenza and other viruses with pandemic potential. Selected contractors will provide essential services, personnel, and facilities to produce vaccines, antigens, and adjuvants, while generating the necessary analytical, nonclinical, clinical, and chemistry, manufacturing, and controls data for FDA submission to support rapid regulatory decisions. To be eligible, offerors must be capable of producing vaccines against influenza strains with pandemic potential and demonstrate success through a U.S. influenza vaccine license or a submitted Biologics License Application. The government intends to award contracts to four offerors based on the Highest Technically Rated Offerors with a Fair and Reasonable Price methodology. Evaluation focuses on capabilities, past performance, and price, with a minimum requirement of a High Confidence rating for technical capabilities. The contract structure consists of a 60-month base period and a 60-month option period, with a minimum guarantee of 50,000 dollars. Key requirements include the development of comprehensive manufacturing and business continuity plans, adherence to strict ASPR security and cybersecurity standards, and the use of the Department of Treasury Invoice Processing Platform for quarterly invoicing. Performance is monitored through a BARDA dose tracker, and final acceptance is triggered by the submission of a final report and updated dose tracking data.

Barda - Aspr / Daappo / Barda Dcma

POSTED

DEADLINE

USDA SBIR/STTR Topic 8.2 — Plant Production and Protection - Biology

Solicitation # USDA-NIFA-TOPIC-8.2

The USDA National Institute of Food and Agriculture is soliciting proposals under Topic 8.2 for Plant Production and Protection - Biology. This initiative focuses on advancing crop production and protection through the development of innovative plant breeding methods, diagnostic technologies for diseases, and the creation of new food and non-food crop plants. Research efforts are directed toward improving plant characteristics to mitigate biotic and abiotic stresses, developing new genotypes for commercial applications, and creating tools to support the health of natural and domesticated pollinators. This opportunity is a total small business set-aside under the SBIR/STTR mandate, restricting eligibility to companies with fewer than 500 employees. Managed by the United States Department of Agriculture, the program is led by Dr. Christopher Philips. Interested parties can find further details and application guidelines through the NIFA website.

National Institute of Food and Agriculture

POSTED

DEADLINE

MANAGE AND OPERATE THE NATIONAL RENEWABLE ENERGY LABORATORYThe Department of Energy, through the Golden Field Office, is forecasting a contract to manage and operate the National Renewable Energy Laboratory located in Colorado. This initiative falls under NAICS code 541711 and is currently associated with the incumbent contractor, Alliance for Energy Innovation, LLC. The opportunity is listed as a forecast with a posted date of October 25, 2026. Yolanda Dixon serves as the Small Business Program Manager and primary point of contact for this requirement.

Golden Field Office

POSTED

DEADLINE

USSF SLD 30: Integrated Development Planning and Environmental Readiness Process Prototype

Solicitation # 61fb4c07-b7d0-4646-987e-dbc1c624d7cf

Space Launch Delta 30 is seeking industry, academic, and non-profit partners to prototype an integrated development planning and environmental readiness process. The goal is to replace the Department of the Air Force's fragmented legacy planning system, which currently takes over nine months to produce low-fidelity concepts, with a unified methodology. This effort focuses on the creation of a repeatable business process rather than physical construction or facility delivery. The objective is to utilize agile design charrettes and concurrent environmental analysis to compress the planning lifecycle, aiming to produce a high-fidelity 30% to 35% conceptual planning package and complete environmental documentation in under five months. This multi-phase prototype begins with Phase I, focusing on Small-Scale Project Process Prototype support for SLC-9. The final deliverable is a government-owned Technical Data Package that codifies this accelerated planning process.

Department Of Defense

POSTED

DEADLINE

Quantitative Analysis of Longitudinal MR Images

Solicitation # 75N98027R00005

Solicitation 75N98027R00005 is a Sources Sought notice issued by the National Institute on Aging (NIA) to identify qualified companies capable of performing quantitative analysis of longitudinal Magnetic Resonance (MR) images. The project supports the Baltimore Longitudinal Study of Aging (BLSA) by processing 300 newly acquired MR datasets to characterize brain aging trajectories and identify predictors of cognitive decline and Alzheimer’s disease. The selected contractor will provide specialized, non-commercial services to deliver global and regional tissue volumes, lesion quantification, and machine learning-derived scores, such as SPARE-AD, while ensuring longitudinal consistency with data acquired since 1994. The anticipated contract will be a firm fixed price award with a period of performance of one year. Key deliverables include quantitative volumetric results, intermediate processing files, and registration maps for PET overlay, submitted every six months, concluding with a final report. Technical requirements emphasize the use of established image analysis tools and adherence to FISMA/FedRAMP-aligned data security controls to protect participant confidentiality. Interested respondents must submit a capability statement by November 9, 2026, to Contract Specialist Sneha Singh. The submission must be limited to ten pages and include the company's Unique Entity ID, NAICS code 541714, professional qualifications of personnel, and any applicable GSA schedules or government-wide acquisition contracts. Small businesses are encouraged to respond to this market research effort to help the government determine the appropriate acquisition method.

National Institutes Of Health Olao

POSTED

DEADLINE

Tactical ISR Processing, Exploitation and Dissemination (PED): Adaptive AI and Autonomy at the Tactical Edge

Solicitation # 1f829fd0-4f36-4a90-a3b7-d05d41483223

The National Geospatial-Intelligence Agency is seeking prototype solutions under an Other Transaction Authority vehicle to develop edge-deployable computer vision capabilities for unclassified small unmanned aerial systems. The primary goal is to enable sustained tactical intelligence, surveillance, and reconnaissance operations in contested and austere environments where connectivity is limited. By focusing on object detection, tracking, and re-identification, the project aims to eliminate the current dependency on enterprise cloud infrastructure for model retraining, allowing warfighters to maintain continuous custody of objects of interest. The required solution must utilize low-shot learning approaches, enabling operators with minimal coding expertise to adapt models at the point of need using limited labeled data on size, weight, and power constrained hardware. Success will be measured by specific precision, recall, and F1 thresholds, as well as the ability to re-identify objects after a loss of custody. To ensure operational utility, the prototype must integrate with standard GEOINT data formats, REST API architectures, and tactical dissemination systems such as the TAK ecosystem.

Department Of Defense

POSTED

DEADLINE

Development and Implementation of a Tactical Innovation Training Program for XVIII Airborne Corps Division

Solicitation # 86085f9a-9f52-4cb7-849f-ebf46cc5b296

The XVIII Airborne Corps is seeking a partner to co-develop and implement a comprehensive tactical innovation training program designed to operationalize innovation within Division innovation labs. The initiative aims to bridge a critical capability gap by establishing a formalized, scalable framework that empowers Soldiers to serve as tactical innovation officers. Participants will be trained in essential methodologies, including problem identification, experimentation, modernization pathways, defense acquisition, and program management, to ensure the organization can systematically solve complex operational challenges from the tactical level up. The required training program will consist of a blended learning approach, featuring approximately three to four months of remote instruction culminating in a mandatory in-person intensive scheduled for December 7-11. The selected partner must tailor the curriculum to align with specific organizational priorities and operational requirements, utilizing practical exercises and facilitation to ensure actionable results. The ultimate goal is to build a sustainable internal capacity for structured problem-solving that enhances mission effectiveness and maintains a competitive operational advantage.

Department Of Defense

POSTED

DEADLINE

AI-Assisted Chatbot and TA Knowledge Base DevelopmentThis subcontract opportunity with the Department of Health and Human Services focuses on the development and implementation of a curated knowledge repository and an AI-driven interface for prime contractors working on Administration for Community Living projects. The selected provider will be responsible for building a searchable Technical Assistance Knowledge Base and deploying an AI-assisted chatbot designed to automate the delivery of authoritative guidance. The project requires specialized expertise in AI/ML development and Knowledge Management architecture to ensure the successful delivery of a functional chatbot and a comprehensive knowledge base. Performance for this contract will take place in Rockville, Maryland, with a response deadline set for November 3, 2026.

Department Of Health And Human Services

POSTED

DEADLINE