This Solicitation opportunity from Department Of Health And Human Services was posted on September 27, 2024. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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A--Request for Proposals - Phase I Clinical Trials

Closed

75N95024R00086Federal

Submission Closed10/11/2024, 09:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

Active Opportunities Like This One

NAICS: 541715

New

Federal

U.S. Army Contracting Command – Watervliet Arsenal (ACC-WVA) Organic Industrial Base (OIB) Modernization Commercial Solutions Opening (CSO)

Solicitation # W911PT26SC001

The U.S. Army Contracting Command – Watervliet Arsenal (ACC-WVA) has issued solicitation W911PT26SC001, a Commercial Solutions Opening (CSO) authorized under the National Defense Authorization Act for Fiscal Year 2026 and DFARS Subpart 212.70. This competitive solicitation is open until September 30, 2027, and is designed to acquire innovative commercial products, technologies, and services to modernize the Army's Organic Industrial Base. The scope focuses on integrating manufacturing resources, linking legacy analogue systems with digital systems, and expanding modeling and simulation to enhance the delivery of materiel solutions. The CSO targets both traditional and non-traditional business entities, including small businesses and foreign-owned firms, provided they maintain an active System for Award Management (SAM) profile and a Unique Entity ID. The acquisition process follows a multi-phased approach consisting of a written solution brief, an optional presentation or pitch, and a final Request for Commercial Solution Proposal (CSP). Evaluation is based on responsiveness, technical merit, uniqueness, and price reasonableness. Successful responses may result in fixed-price contracts awarded under FAR Part 12 Commercial Item Procedures. Current Areas of Interest (AoIs) include advanced cannon technology, electrical infrastructure improvements at Building 120, chromium facility conversion, automated manufacturing for minor components, automated cooling tower treatments, advanced CNC vertical turning lathes, and advanced tooling for radial forging. Performance is primarily located at Watervliet Arsenal and Benet Laboratories, with a general period of performance not to exceed 12 months unless otherwise specified.

POSTED

DEADLINE

"Provide specialized piping expertise overseeing the Craft Labor/Corrosion Control subcontractor for field modifications at KSC including but not limited to fabrication and installation of piping spool pieces, piping & tubing supports, flared & welded tub

Solicitation # 80NSSC26945986Q

NASA Shared Services Center

POSTED

DEADLINE

Scientific Data Management and Publication SupportThe Scientific Data Management and Publication Support subcontract, issued by the National Institutes of Health under the Department of Health and Human Services, focuses on the dissemination of data, tools, and technologies for prime contractors involved in NIDCD medical research projects. The selected provider will manage resource sharing between laboratories and the NIDCD, assist in the preparation of scientific publications, and implement NIH Data Management and Sharing plans. These tasks must be executed using statistical software and secure data repositories while maintaining strict adherence to NIH cybersecurity guidelines. The primary deliverables for this engagement include the provision of disseminated data sets and the completion of published research papers. This opportunity falls under NAICS code 541715 and has a response deadline of March 5, 2027.

National Institutes Of Health

POSTED

DEADLINE

Human Temporal Bone and Fresh Ear Tissue Processing LaboratoryThis subcontract for the National Institutes of Health involves the receiving and processing of human temporal bones and fresh ear tissue to support research network projects for the NIDCD. The selected provider will be responsible for obtaining specimens from the National Hearing and Balance Organ Donor Program, processing inner and middle ear tissues, scanning slides, and summarizing donor medical records. Final deliverables include the processed specimens, high-resolution scanned images, and comprehensive annotated data. To execute these tasks, the contractor must possess specialized high-resolution slide scanning equipment and maintain strict biohazard containment protocols. Additionally, the provider is required to maintain an active IRB certification throughout the duration of the project. This effort falls under NAICS code 541715 and is managed under the Department of Health and Human Services.

National Institutes Of Health

POSTED

DEADLINE

Coordinating Center for National Resource Network for the Study of Human Auditory and Vestibular Disorders (U24 Clinical Trial Not Allowed)

Solicitation # RFA-DC-28-002

Solicitation RFA-DC-28-002 is a Notice of Funding Opportunity from the National Institutes of Health, specifically the National Institute on Deafness and Other Communication Disorders, to establish a Coordinating Center for the NIDCD National Human Ear Resource Network. This collaborative network provides human inner and middle ear tissues to researchers for basic and clinical studies aimed at advancing the treatment of auditory and vestibular disorders. The Coordinating Center is responsible for maintaining network cohesiveness through the planning of workshops, symposia, and regular meetings, providing updates to laboratories, and managing communication with the public and scientific community regarding tissue donation. The maximum project period is five years, with a budget limit of 200,000 dollars in direct costs per year. Applicants, including for-profit organizations and small businesses, must maintain active registrations in SAM, eRA Commons, and Grants.gov. Proposals are evaluated based on the significance of the proposed center and the qualifications of the investigators, with additional reviews for human subject protections, inclusion policies, and the use of vertebrate animals. Key requirements include a structured Data Management and Sharing Plan and adherence to cybersecurity guidelines, including a 48-hour incident reporting window. The application process is entirely electronic and requires several standard PHS and SF424 forms, with a response deadline of March 5, 2027.

National Institutes Of Health

POSTED

DEADLINE

National Resource Network for the Study of Human Auditory and Vestibular Disorders (U24 Clinical Trial Not Allowed)

Solicitation # RFA-DC-28-001

Solicitation RFA-DC-28-001 is a Notice of Funding Opportunity issued by the National Institutes of Health under the Department of Health and Human Services to support the NIDCD National Human Ear Resource Network. The objective is to maintain a collaborative network of laboratories that serve as a national technological resource, providing human inner and middle ear tissues to researchers for basic and clinical studies to advance the treatment of auditory and vestibular disorders. The scope of work includes processing human temporal bones from the National Hearing and Balance Organ Donor Program, uploading images and medical data to EarBase, sharing gene-expression data via the gEAR repository, and providing technical instruction to increase the number of skilled researchers in the field. The NIDCD intends to commit 3.6 million dollars in FY 2028 to fund up to six awards, with a maximum project period of five years. Individual awards are limited to 450,000 dollars in direct costs per year, with an additional 150,000 dollars available for specific subawards. Applications are due on March 05, 2027, and November 01, 2027, with staggered start dates ranging from July 2027 to July 2028. Evaluation is based on the experience of the investigators, the adequacy of the institutional environment, and the protection of human subjects. Applicants must maintain active SAM registration and a Unique Entity Identifier, and they must provide a Data Management and Sharing Plan and a Material Transfer Agreement. Compliance with the Cybersecurity Act of 2015 is required, including the development of an incident response plan and notification of cybersecurity incidents within 48 hours of discovery.

National Institutes Of Health

POSTED

DEADLINE

Silviculture Growth & Yield Modelling SpecialistThe Silviculture Growth and Yield Modelling Specialist subcontract supports prime contractors on projects for the Province of British Columbia's Ministry of Forests. The selected specialist will perform advanced statistical analysis and growth and yield modelling, specifically utilizing the Mixedwood Growth Model to establish stocking standards for conifer, broadleaf, mixedwood, and successional forests. A primary objective of the role is the creation of algorithms designed to project stand attributes based on data gathered from free growing surveys. Candidates must possess advanced proficiency in statistical analysis software and extensive expertise with the Mixedwood Growth Model to successfully deliver the required projection algorithms and modelled results. This opportunity was posted on October 19, 2026, with a response deadline of October 29, 2026.

POSTED

DEADLINE

Mental Health Screening Tool Array DesignThis subcontract, titled Mental Health Screening Tool Array Design, involves providing clinical content and validated screening tools to prime contractors working on Illinois State Board of Education projects. The primary objective is to develop specialized tool arrays capable of identifying childhood mental health challenges related to internalizing, externalizing, and trauma. To ensure clinical efficacy and legal compliance with Public Act 104-0032, the tools must be optimized for administration in under ten minutes. The final deliverable consists of a validated set of screening tools fully integrated into the designated platform. This project is managed under the Community Residential Services Authority for the state of Illinois.

COMRESSERVAUTH586 - Community Residential Services Authority

POSTED

DEADLINE

Notice of Correction to Award Information and Application and Submission Information for PA-27-037 "Predoctoral to Postdoctoral Transition Award (Parent F99/K00 - Clinical Trial Not Allowed)"

Solicitation # NOT-OD-26-091

This notice provides corrections to the award and application information for the Predoctoral to Postdoctoral Transition Award (Parent F99/K00), specifically for solicitation NOT-OD-26-091 issued by the National Institutes of Health. The primary updates involve the removal of Kirschstein-NRSA support period limitations. Eligible individuals may now receive up to five years of aggregate support, consisting of up to two years at the F99 predoctoral level and up to three years at the K00 postdoctoral level. Additionally, the notice clarifies that a Certification Letter is no longer required for these applications, and corresponding instructions have been removed from the SF424(R&R) Other Project Information section. These changes are effective for the application due date of August 8, 2026. For further inquiries, the Division of Biomedical Research Workforce serves as the primary point of contact.

National Institutes Of Health Office Of The Director

POSTED

DEADLINE

Notice of NIBIB Participation in PA-27-037: Predoctoral to Postdoctoral Transition Award (Parent F99/K00 - Clinical Trial Not Allowed)

Solicitation # NOT-EB-26-005

The National Institute of Biomedical Imaging and Bioengineering is joining the Predoctoral to Postdoctoral Transition Award (Parent F99/K00), effective for applications received on or after December 08, 2026. This funding opportunity is designed for researchers transitioning from predoctoral to postdoctoral training, provided that clinical trials are not involved. All submitted applications must align with the specific missions of the participating Institutes and Centers. This update expands the list of participating organizations and agency contacts to include the National Institute of Biomedical Imaging and Bioengineering and its Chief Grants Management Officer. The award is supported by a wide array of National Institutes of Health offices and centers, including the National Cancer Institute and the National Institute on Aging, among others. All other terms and conditions of the original notice of funding opportunity remain unchanged.

National Institute Of Biomedical Imaging And Bioengineering

POSTED

DEADLINE

Notice of FIC Participation in PA-26-002 "NIH Collaborative International Research Project (Parent PF5 Clinical Trial Optional)"

Solicitation # NOT-TW-26-002

The Fogarty International Center is participating in the NIH Collaborative International Research Project, identified as PA-26-002. This funding opportunity is effective for applications submitted on or after January 25, 2027. The program is designed for collaborative international research projects and allows for optional clinical trials. A wide array of NIH Institutes and Centers are participating organizations, and applications must align with their specific missions. Additionally, the Office of Research on Women's Health, the INCLUDE Project, and the Office of Data Science Strategy may provide co-funding for assigned applications. All other terms and conditions of the original notice of funding opportunity remain unchanged.

POSTED

DEADLINE

Thermal Performance & Dielectric Testing LaboratoryThis subcontract opportunity is for a Thermal Performance and Dielectric Testing Laboratory to provide independent testing and validation services for prime contractors supporting USAF AFLCMC/WAR F-22 cooling fluid projects. The selected provider will be responsible for evaluating low-temperature viscosity, high-temperature stability, and dielectric strength utilizing specialized equipment such as viscosity meters and stability chambers. The final deliverables for this engagement include comprehensive technical test reports and performance validation data. To be eligible, the contractor must be a domestic U.S. company and hold ISO/IEC 17025 accreditation. The work is associated with NAICS code 541715 and will be performed at Wright Patterson AFB. Interested parties must submit their responses by November 3, 2026.

FA8611 Aflcmc Wauk F22

POSTED

2 days ago

DEADLINE

in 14 days

AI Contract Overview

The contract pertains to a Request for Proposals issued by the National Institutes of Health (NIH), specifically under the Department of Health and Human Services, for conducting Phase I clinical trials focused on the development of small molecule and biologic therapeutics. The solicitation, identified by number 75N95024R00086, was posted on September 27, 2024, with a response deadline extended to October 11, 2024, at 5 pm ET. The contract emphasizes the need for vendors to support early-stage clinical testing, likely involving specialized services aligned with NAICS code 541715, which pertains to research and development in the physical, engineering, and life sciences. The solicitation has undergone multiple amendments to clarify and update the requirements. Amendment 0002 responded to vendor questions, revised key sections of the RFP and related attachments, and extended the submission deadline. Amendment 0003 further addresses additional vendor inquiries, ensuring clarity and transparency in the procurement process. The contract is managed through a point of contact, Evan C. Feely, whose contact details are provided for further inquiries. The procurement process is accessible via the provided link on SAM.gov, facilitating vendor engagement and submission of proposals for this critical clinical research initiative.

General Info

Phase I clinical trials for small molecule and biologics therapeutics, RFP, NIH, deadline 10/11/2024.

Agency

Department Of Health And Human Services → National Institutes Of Health Nida

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Set-Aside

NONE

Documents

75N95024R00086 Amendment 0001

amendment

High

75N95024R00086 Amendment 0002

amendment

High

75N95024R00086 Amendment 0002

amendment

High

75N95024R00086 Amendment 0003

amendment

High

75N95024R00086 Amendment 0003

amendment

High

75N95024R00086 - Phase I Clinical Trials for Development of Small Molecule and Biologics Therapeutics

rfp

High

A11 - Additional Technical Proposal Instructions

sow

High

A12 Summary of Related Activities

supporting-documents

High

A18 Determination of Exceptional Circumstances Acknowledgment Form

special-notice

High

A24 Public Health Surveillance Exclusion Request Guidance

specifications

High

Attachment 1 - Packaging and Delivery of Proposals (NIH eCPS)

specifications

High

IDIQ Contract Statement of Work - Phase I Clinical Trials

sow

High

NIDA Supplemental Billing Instructions (Exhibit A to NIH(RC)-1)

specifications

High

RFP 75N95024R00086 - Phase I Clinical Trials for Development of Small Molecule and Biologics Therapeutics

rfp

High

Sample Task Order #1 - SOW: Project Management Plan and Kick-Off Meeting

sow

High

Sample Task Order #2 - SAD Study SOW

sow

High

Sample Task Order #3 - SAD/MAD Study SOW

sow

High

Section K - Representations, Certifications, and Other Statements of Offerors

representations-certifications

High

Technical Proposal Cost Summary of Labor and Direct Costs

specifications

High

Wage Determination No. 2015-4269 (Revision 26)

wage-determination

High

A22 - PHS Human Subjects and Clinical Trials Information Form-H

other

Low

A5 - Offeror's Points of Contact

other

Low

HHS Industry User Guide for Subcontracting Plan Reviews

other

Low

NIH-2043 Proposal Summary and Data Record

other

Low

NIH(RC)-1 Invoice/Financing Request Instructions

supporting-documents

Low

NIH(RC)-2 Fixed-Price Invoice Instructions

other

Low

OMB Form SF-LLL - Disclosure of Lobbying Activities

other

Low

Protection of Human Subjects Assurance Identification/IRB Certification Form

other

Low

RFP 75N95024R00086 Proposal Intent Response Form

other

Low

A14_-_Breakdown_of_Proposed_Estimated_Costs.xlsx

AI Contract Breakdown

Uniform Contract Format

Contract not broken down yet

CLEATUS splits the solicitation into Uniform Contract Format (UCF) sections: scope, pricing, deliverables, and evaluation criteria.

Timeline

7 updates

PhaseClosed

PostedJul 16

Presolicitation

Deadline changedJul 29

Response deadline changed from Jul 31, 2024 to Aug 7, 2024.

Deadline changedAug 7

Response deadline changed from Aug 7, 2024 to Aug 14, 2024.

Notice updatedAug 15

Response deadline changed from Aug 14, 2024 to Aug 16, 2024. The notice description changed.

Notice updatedAug 16

Response deadline changed from Aug 16, 2024 to Aug 19, 2024. The notice description changed.

Type ChangedAug 19

Presolicitation → Solicitation

Notice updatedAug 19

The notice title changed.

Notice updatedSep 20

Response deadline changed from Oct 3, 2024 to Oct 11, 2024. The notice description changed.

Notice updatedSep 27

The notice description changed.

Response DeadlineOct 11

Deadline has passed

Submission Closed

10/11/2024, 09:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → National Institutes Of Health Nida

Contacts1 person available

OfficeBethesda, MD, 20892, USA

Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health Nida

Office AddressBethesda, MD, 20892, USA

Contacts

FEELY EVAN C

contact@example.gov

+1 (555) 000-0000

Full Description

Amendment 0003: The attached amendment provides responses to additional vendor-submitted questions. Amendment 0002: The attached amendment provides responses to vendor-submitted questions; revises the RFP document and RFP Attachments 9 and 10 (Sample Task Order #2 and #3 SOWs); and extends the response deadline to 10/11/2024 at 5 pm ET. Phase I Clinical Trials for Development of Small Molecule and Biologics Therapeutics