BRAIN Initiative Cell Atlas Network (BICAN): Coordinating Unit for Biostatistics, Informatics, and Engagement (CUBIE)
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The National Institute of Mental Health, along with other NIH Institutes and Centers, plans to issue a funding opportunity for the BRAIN Initiative Cell Atlas Network's Coordinating Unit for Biostatistics, Informatics, and Engagement (CUBIE). This initiative aims to continue supporting a 2-year renewal to facilitate the exploration and analysis of large-scale brain cell atlas data, promoting research on brain function and disorders. Key objectives include ensuring the data and research processes adhere to the FAIR principles—making the data findable, accessible, interoperable, and reusable—and maintaining transparency, rigor, and reproducibility in research outcomes. Applicants are expected to work collaboratively with the broader research community to analyze all existing brain cell census and atlas data, with the goal of enhancing statistical power and fostering a cohesive brain cell atlas ecosystem. The initiative also emphasizes leveraging recent advances in artificial intelligence and machine learning to advance data interpretation and research quality. Applications will undergo NIH standard peer-review processes, with only high-quality submissions considered for funding. Although applications are not currently being accepted, this notice serves to inform potential applicants and allow adequate time for the development of meaningful collaborations and project proposals.
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The National Institute of Mental Health (NIMH), with other NIH Institutes and Centers (ICs), intends to publish a notice of funding opportunity (NOFO) to solicit research applications for the BRAIN Initiative Cell Atlas Network (BICAN) Coordinating Unit for Biostatistics, Informatics, and Engagement (CUBIE). In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding. The overall goals of CUBIE are to (i) enable the exploration of large-scale brain cell atlas data and knowledge, and inspire research in brain function and disorders; and (ii) ensure research rigor and data reproducibility by making the data Findable, Accessible, Interoperable, and Reusable (FAIR), and the process transparent. This is a renewal that will continue the funding for a 2-year period. Applications are not being solicited at this time. Notice is being provided to allow eligible applicants sufficient time to develop meaningful collaborations and responsive projects. Applications are expected to collaborate with the broader research community to analyze and interpret all existing brain cell census/atlas data to enhance statistical power, ensure research rigor and data reproducibility, and foster the formation of a brain cell atlas ecosystem by leveraging recent Artificial Intelligence/Machine Learning (AI/ML) advancements.
