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Functional Target Validation for Alzheimer's Disease-Related Dementias

Active
Grant

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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The National Institute of Neurological Disorders and Stroke is seeking ambitious research projects focused on the comprehensive functional validation of new therapeutic target candidates for Alzheimer’s Disease-Related Dementias. The primary goal is to bridge the gap between basic discoveries and clinical application by establishing a causal relationship between target modulation and physiological consequences, thereby reducing risk for future translational research and accelerating the development of new treatments. This initiative will likely utilize a phased award mechanism, such as an R61/R33 grant. The first phase focuses on developing customized technologies, models, and protocols to modulate candidate targets in disease models. Upon meeting specific milestone-based criteria, projects will transition to a second phase dedicated to cross-validating these effects across multiple modalities and laboratories. While this is currently a forecast and applications are not yet being solicited, the notice serves to allow researchers time to establish the necessary cross-disciplinary collaborations.

General Info

Support for phased research validating therapeutic targets for Alzheimer’s Disease–Related Dementias.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

(0)

No documents available

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Timeline

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUSA
Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health
Office AddressUSA
Contacts
NINDS DTR ADRD
contact@example.gov

Full Description

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The National Institute of Neurological Disorders and Stroke (NINDS) is interested in supporting ambitious research projects that propose comprehensive functional validation of newly identified therapeutic target candidates for Alzheimer’s Disease–Related Dementias (ADRD). A major barrier to the development of effective treatments for ADRD, as well as other complex central nervous system disorders, is the lack of well-validated targets that are clearly linked to disease mechanisms. Successful translation of basic discoveries into the clinic depends on the rigor of target validation and confidence in a causal relationship between modulation of a target and its functional physiological consequences relevant to treating or preventing disease. This initiative aims to de-risk subsequent translational research and accelerate the development of novel therapeutic strategies.

NINDS believes that this initiative would be most appropriately supported by a phased award mechanism (for example, R61/R33).  In the initial phase, support would be provided for the development of customized technologies, models, and protocols to modulate the expression or activity of candidate targets and to assess their physiological consequences in relevant in vitro and in vivo disease models. Upon successful achievement of predefined, milestone-based technical feasibility and proof-of-concept criteria, projects would transition to the second phase focused on measuring and cross-validating the effects of target modulation across multiple experimental modalities and collaborating laboratories, in accordance with NIH rigor and reproducibility guidelines.

Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop responsive projects and establish appropriate cross-disciplinary collaborations.

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