RNomics Technology Enhancement Centers

The NIH Common Fund, in collaboration with multiple NIH Institutes and Centers, is preparing to issue a funding opportunity for the RNomics program, specifically targeting the establishment of Technology Enhancement Centers (RTECs) aimed at advancing tools for comprehensive RNA analysis. These centers will build upon existing technologies with proven feasibility to improve methods for measuring, mapping, and testing RNA molecules across cells and tissues, with a focus on delivering practical, widely accessible enhancements. Key priorities include end-to-end RNA sequencing, quantitative mapping of RNA modifications, and integrated analysis of RNA sequence, structure, modification, interactions, localization, dynamics, and function, as well as the development of molecular and biochemical tools for RNA manipulation and functional validation. The RTECs are one component of the broader RNomics initiative, which also encompasses transformative technologies, molecular standards, and a coordinating center, all designed to enable a holistic understanding of the RNome and its role in health and disease. While applications are not currently being accepted, this forecast notice provides advance notice to help potential applicants form strong collaborations and refine project proposals. The opportunity is listed under NAICS code 541715, sponsored by the National Institutes of Health under the Department of Health and Human Services, with inquiries directed to the Common Fund RNomics Program at cfrnomics@od.nih.gov and further information available via the Grants.gov portal.