Transformative Technologies for Experimental and Computational RNome Characterization and Functional Analysis

The NIH Common Fund, in collaboration with multiple NIH Institutes and Centers, is preparing to issue a funding opportunity for the Transformative Technologies initiative under the RNomics program, aimed at developing groundbreaking experimental and computational tools to characterize the full spectrum of RNA molecules in biological systems. This initiative targets high-risk, early-stage innovations that overcome significant limitations in current RNA analysis methods, with a focus on technologies for sequencing RNA, detecting chemical modifications, studying RNA functionality, and analyzing RNA across individual molecules, cells, and tissues. Projects will be structured in two phases, with Phase 1 supporting initial development and proof-of-concept work, and successful proposals eligible for transition to Phase 2, where validated, scalable tools will be delivered for broad community use. The program emphasizes the creation of resources that enable integrated analysis of RNA sequences, structures, modifications, locations, interactions, and functions to deepen understanding of health and disease mechanisms. While applications are not yet being accepted, this forecast notice provides prospective applicants with advance notice to build collaborative teams and refine innovative proposals. The initiative is part of a broader RNomics effort that also includes technology enhancement centers, molecular standards, and a coordinating center, all working toward a unified framework for RNA research. The opportunity is managed by the National Institutes of Health under the Department of Health and Human Services, and inquiries may be directed to the Common Fund RNomics Program at cfrnomics@od.nih.gov. The forecasted posting date for the formal solicitation is August 5, 2026.