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Brain Repair of Any Injured Neural Structure (BRAINS)

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ARPA-H-SOL-26-148Federal

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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The Advanced Research Projects Agency for Health (ARPA-H) is seeking innovative solutions through the Brain Repair of Any Injured Neural Structure (BRAINS) Exploratory Topic program, solicitation number ARPA-H-SOL-26-148. This 18-month initiative aims to develop technologies for regrowing region-specific brain tissue from transplanted precursor tissue to restore function lost to injury or disease. The program focuses on target regions such as the hippocampus, amygdala, thalamus, and cerebellum, while specifically excluding the neocortex and spinal cord. The scope is divided into two technical areas: the generation of precursor tissue and the validation of surgical delivery. Successful projects must demonstrate that precursor tissue is over 80 percent similar to natural counterparts and that grafted tissue achieves vascularization within 48 hours and survives for at least 21 days. ARPA-H intends to award multiple Other Transaction agreements based on overall scientific and technical merit, proposer capabilities, and cost reasonableness. Interested parties must first submit a mandatory solution summary before being eligible to submit a full proposal. The solicitation follows two intake cycles, with the first group's solution summaries due July 9, 2026, and full proposals due August 6, 2026; the second group's summaries are due January 7, 2027, with full proposals due February 6, 2027. Full proposals must be submitted via the ARPA-H Solution Submission Portal in three volumes covering technical and management plans, cost proposals, and administrative and policy requirements. All submissions must comply with HHS regulations regarding human stem cells and strict research security protocols concerning foreign countries of concern.

General Info

ARPA-H seeks innovative technologies to regrow specific brain tissue to restore lost function.

Agency

Department Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Washington, DC, USA

Set-Aside

NONE

Documents

3

ARPA-H ISO ARPA-H-SOL-26-148 Amendment 1 Brain Repair of Any Injured Neural Structure

PDF, High priority: read this firstamendment
High

ARPA-H ISO ARPA-H-SOL-26-148 Brain Repair of Any Injured Neural Structure

PDF, High priority: read this firstiso
High

OT+Bundle+of+Attachments.zip

ZIP

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Timeline

1 update
PhaseSolicitation
Posted

Solicitation

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The notice description changed.

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)
Contacts1 person available
OfficeWashington, DC, 20005, USA
Organization / AgencyDepartment Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)
Office AddressWashington, DC, 20005, USA
Contacts
BRAINS Team
contact@example.gov

Full Description

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June 23, 2026: The purpose of Amendment #1 is to update ISO Section 5.4.4 CRITERIA 4: ASSESSMENT OF PROPOSED COST/PRICE.  All other terms and conditions remain unchanged.


The Advanced Research Projects Agency for Health (ARPA-H) posts this funding opportunity in support of the Brain Repair of Any Injured Neural Structure (BRAINS) Exploratory Topic program. ARPA-H anticipates multiple awards with Other Transaction award types resulting from this announcement. Interested parties are invited to review the Innovative Solutions Opening (ISO) ARPA-H-SOL-26-148.


Parties interested in submitting a proposal in response to the ARPA-H BRAINS ISO are required (mandatory) to submit a solution summary. No awards will be made, or funding provided as a result of a solution summary submission.


Intake Group 1: Solution Summaries Due: July 9th, 2026, 5:00 PM Full Proposals Due: August 6th, 2026, 5:00PM


Intake Group 2: Solution Summaries Due: January 7th, 2027, 5:00 PM Full Proposals Due: February 6th, 2027, 5:00PM


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