This Solicitation opportunity from Department Of Health And Human Services was posted on May 26, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Innovative Solutions Opening (ISO)

Closed

ARPA-H-SOL-26-139Federal

Submission Closed05/28/2026, 05:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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NAICS: 541715

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POSTED

in 7 months

DEADLINE

N/A

AI Contract Overview

The Advanced Research Projects Agency for Health (ARPA-H) has issued a solicitation under the Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Innovative Solutions Opening (ISO) aimed at advancing critical care outcomes in intensive care units by addressing immuno-inflammatory dysregulation before it leads to organ failure. This effort focuses on developing a Control Point Validation Engine capable of assessing, predicting, and guiding treatment to improve patient outcomes, reduce ICU stay durations, and lower associated healthcare costs. ARPA-H plans to award multiple Other Transaction Agreements as part of this initiative, inviting innovative proposals that demonstrate technical excellence and effective project management. The solicitation (ARPA-H-SOL-26-139) was posted on April 28, 2026, with key deadlines including a proposer’s day on March 11, 2026, solution summaries due by March 30, 2026, and the full proposal submission deadline on May 28, 2026. Proposals must follow detailed instructions that emphasize concise, well-structured responses covering goals, impact, technical plans, and management capabilities. Amendments to the solicitation have adjusted submission deadlines and clarified administrative details. The solicitation is open with no set-aside restrictions, and ARPA-H cautions proposers that no reimbursement for proposal preparation is provided and that submission processes may take from one business day to one month. The solicitation and related documents provide comprehensive guidance to ensure compliant and competitive submissions geared toward transformative solutions in ICU critical illness care.

General Info

ARPA-H seeks innovative proposals for ICU immuno-inflammatory control to improve outcomes and reduce costs.

Agency

Department Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) View NAICS

Place of Performance

DC, USA

Set-Aside

NONE

Documents

(13)

ARPA-H-SOL-26-139 Technical and Management Proposal Instructions

DOCX•7 pages•sow

ARPA-H ISO CIRCLE Critical Illness Immunological Reprogramming

PDF•62 pages•iso

ARPA-H-SOL-26-139 Technical & Management Document

PDF•sow

Administrative and National Policy Requirements Document

DOCX•sow

Volume 2 Price-Cost Proposal Workbook (Resource Sharing) Version 1.06.02

XLSX•price-cost-proposal-workbook

VOLUME2 PRICE-COST PROPOSAL WORKBOOK (Resource Sharing) CIRCLE Amendment 04

XLSX•modification

ARPA-H-SOL-26-139 Amendment 4 for CIRCLE Innovative Solutions Opening

DOCX•amendment

ARPA-H Task Description Document Template

DOCX•sow

ARPA-H-SOL-26-139 Amendment 3 for CIRCLE ISO

PDF•amendment

ARPA-H SOL-26-139 Amendment 1 - CIRCLE Innovative Solutions Opening

PDF•amendment

ARPA-H CIRCLE ISO Solution Summary Template

DOCX•template

Sample ARPA-H Other Transaction Agreement Model

DOCX•contract-document

ARPA-H-SOL-26-139 Amendment 2 - CIRCLE ISO

PDF•amendment

AI Contract Breakdown

Uniform Contract Format

Timeline

4 updates

PhaseClosed

Amendment 2Mar 23

Contract was updated

Amendment 3Apr 28

Contract was updated

Amendment 4May 21

Contract was updated

PostedMay 26

Solicitation

Amendment 5May 26

Contract was updated

Response DeadlineMay 28

Deadline has passed

Submission Closed

05/28/2026, 05:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)

Contacts1 person available

OfficeWashington, DC, 20005, USA

Organization / Agency

Department Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)

Office AddressWashington, DC, 20005, USA

Contacts

ARPA-H RSO CIRCLE ISO Coordinator

contact@example.gov

Full Description

Responses to all questions received have been posted on the CIRCLE program page. At this time, additional questions will not receive responses.

The Advanced Research Projects Agency for Health (ARPA-H) is posting this Innovative Solutions Opening (ISO) solicitation in support of the Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Program. ARPA-H anticipates that multiple Other Transaction (OT) Agreements will result from this announcement.

CIRCLE seeks to create a critical illness Control Point Validation Engine that leads to improvements in intensive care unit (ICU) health outcomes, coupled to reduced stay time and associated costs, by assessing, predicting, and treating immuno-inflammatory dysregulation before it causes organ failure.

Interested parties are invited to review the attached CIRCLE ISO ARPA-H-SOL-26-139 and its Attachments A – F.

Proposer's Day: Wednesday, March 11, 2026 (ARPA-H-SN-26-149)

Solution Summaries Due: Monday, March 30, 2026, 1 PM ET (to https://solutions.arpa-h.gov)

Questions Due: Friday, May 22, 2026, 1 PM ET (to https://solutions.arpa-h.gov/Ask-A-Question/)

Full Proposals Due: Thursday, May 28, 2026, 1 PM ET (to https://solutions.arpa-h.gov)

ARPA-H will not reimburse potential proposers for time and effort related to submission of solution summaries or proposals. When planning a response to this notice, proposers should consider that some parts of the submission process may take from one business day to one month to complete.

-------------------------- Amendment 1 --------------------------

The purpose of this amendment is to: change the proposal submission date to Thursday, May 28, 2026 and replace Office of Commercialization (OC) with ARPA-H.

-------------------------- Amendment 2 --------------------------

The purpose of this amendment is to provide revisions as highlighted in yellow in the attached documents.

-------------------------- Amendment 3 --------------------------

The purpose of this amendment is to provide revisions as highlighted in yellow in the attached documents.

-------------------------- Amendment 4 --------------------------

The purpose of this amendment is to provide revisions as highlighed in yellow in the attached documents.