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This Solicitation opportunity from Department Of Health And Human Services was posted on May 26, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Innovative Solutions Opening (ISO)

Closed
ARPA-H-SOL-26-139Federal

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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AI Contract Overview

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The Advanced Research Projects Agency for Health (ARPA-H) is seeking innovative proposals through an Innovative Solutions Opening (ISO) under solicitation ARPA-H-SOL-26-139 to advance the CIRCLE Program, which aims to develop a Control Point Validation Engine capable of assessing, predicting, and intervening in immuno-inflammatory dysregulation before it leads to organ failure in critically ill patients. The program targets improved intensive care unit outcomes and reduced hospital stays by integrating dynamic immune monitoring, detailed patient immune state modeling, and targeted immune reprogramming interventions across three Technical Areas: TA1 for rapid, tissue-localizable immune data collection; TA2 for computational modeling of immune states; and TA3 for control point modulation and intervention. Proposals must be submitted as either Type A, covering all three Technical Areas, or Type B, focusing on one Associate Performer role, using mandatory templates provided in Attachments A through F. The submission process requires a Solution Summary by March 30, 2026, followed by a Full Proposal due by May 28, 2026, both via the ARPA-H Solution Site, with no additional questions being answered after initial postings. Proposals will be evaluated based equally on Overall Scientific and Technical Merit (50%) and Proposer’s Capabilities and Related Experience (50%), with emphasis on innovation, feasibility, risk mitigation, intellectual property structure, and the technical team’s proven expertise. The award instrument is an Other Transaction Agreement, governed by a Model OT Agreement in Attachment E, which allows proposers to propose non-administrative edits with supporting rationale—otherwise, acceptance of all terms is assumed. All proposers must be registered in SAM.gov with an active UEI and provide a good faith representation of IP ownership or licensing rights. The program spans five years and includes mandatory milestones such as establishing metrics and agreements within three months of award, finalizing research protocols within six months, and meeting annual performance targets. Payment is milestone-based via the Payment Management System, contingent on verification by ARPA-H staff, and requires compliance with human subjects research regulations, security assessments for covered personnel, and controlled information handling standards. No set-aside is in place, and awards will be made based on proposal quality and funding availability, with no cost or contract value pre-established, and proposers required to submit custom budget details through the provided workbook.

General Info

ARPA-H seeks innovative proposals for ICU immuno-inflammatory control to improve outcomes and reduce costs.

Agency

Department Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)View Agency

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)View NAICS

Place of Performance

DC, USA

Set-Aside

NONE

Documents

(13)

ARPA-H-SOL-26-139 Technical and Management Proposal Instructions

DOCX7 pagessow

ARPA-H ISO CIRCLE Critical Illness Immunological Reprogramming

PDF62 pagesiso

ARPA-H-SOL-26-139 Technical & Management Document

PDFsow

Administrative and National Policy Requirements Document

DOCXsow

Volume 2 Price-Cost Proposal Workbook (Resource Sharing) Version 1.06.02

XLSXprice-cost-proposal-workbook

VOLUME2 PRICE-COST PROPOSAL WORKBOOK (Resource Sharing) CIRCLE Amendment 04

XLSXmodification

ARPA-H-SOL-26-139 Amendment 4 for CIRCLE Innovative Solutions Opening

DOCXamendment

ARPA-H Task Description Document Template

DOCXsow

ARPA-H-SOL-26-139 Amendment 3 for CIRCLE ISO

PDFamendment

ARPA-H SOL-26-139 Amendment 1 - CIRCLE Innovative Solutions Opening

PDFamendment

ARPA-H CIRCLE ISO Solution Summary Template

DOCXtemplate

Sample ARPA-H Other Transaction Agreement Model

DOCXcontract-document

ARPA-H-SOL-26-139 Amendment 2 - CIRCLE ISO

PDFamendment

AI Contract Breakdown

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Timeline

5 updates
PhaseClosed
Posted

Solicitation

Amendment 1

Contract was updated

Amendment 2

Contract was updated

Amendment 3

Contract was updated

Amendment 4

Contract was updated

Amendment 5

Contract was updated

Response Deadline

Deadline has passed

Submission Closed

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)
Contacts1 person available
OfficeWashington, DC, 20005, USA
Organization / Agency
Department Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)
View Agency Profile
Office AddressWashington, DC, 20005, USA
Contacts
ARPA-H RSO CIRCLE ISO Coordinator

Full Description

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Responses to all questions received have been posted on the CIRCLE program page. At this time, additional questions will not receive responses.


The Advanced Research Projects Agency for Health (ARPA-H) is posting this Innovative Solutions Opening (ISO) solicitation in support of the Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Program. ARPA-H anticipates that multiple Other Transaction (OT) Agreements will result from this announcement.


CIRCLE seeks to create a critical illness Control Point Validation Engine that leads to improvements in intensive care unit (ICU) health outcomes, coupled to reduced stay time and associated costs, by assessing, predicting, and treating immuno-inflammatory dysregulation before it causes organ failure.


Interested parties are invited to review the attached CIRCLE ISO ARPA-H-SOL-26-139 and its Attachments A – F.



Proposer's Day: Wednesday, March 11, 2026 (ARPA-H-SN-26-149)


Solution Summaries Due: Monday, March 30, 2026, 1 PM ET (to https://solutions.arpa-h.gov)


Questions Due: Friday, May 22, 2026, 1 PM ET (to https://solutions.arpa-h.gov/Ask-A-Question/)


Full Proposals Due: Thursday, May 28, 2026, 1 PM ET (to https://solutions.arpa-h.gov)



ARPA-H will not reimburse potential proposers for time and effort related to submission of solution summaries or proposals. When planning a response to this notice, proposers should consider that some parts of the submission process may take from one business day to one month to complete.



-------------------------- Amendment 1 --------------------------


The purpose of this amendment is to: change the proposal submission date to Thursday, May 28, 2026 and replace Office of Commercialization (OC) with ARPA-H.



-------------------------- Amendment 2 --------------------------


The purpose of this amendment is to provide revisions as highlighted in yellow in the attached documents.



-------------------------- Amendment  3 --------------------------


The purpose of this amendment is to provide revisions as highlighted in yellow in the attached documents.


-------------------------- Amendment  4 --------------------------


The purpose of this amendment is to provide revisions as highlighed in yellow in the attached documents.

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