Kidney Precision Medicine Project Tissue Interrogation Sites (U01 Clinical Trial Not Allowed)

The National Institutes of Health is soliciting applications for Tissue Interrogation Sites under the Kidney Precision Medicine Project to conduct detailed analysis of human kidney tissue specimens obtained from patients with acute or chronic kidney disease. These sites will work in close coordination with Recruitment Sites, the Kidney Tissue Atlas Coordinating Center, and the Central Hub to process and examine biopsy samples, aiming to generate a comprehensive Kidney Tissue Atlas that maps cellular and molecular features of kidney disease. The goal is to define distinct disease subgroups, identify key cell types and interstitial components, and uncover biological pathways and therapeutic targets that can inform the development of new precision treatments. The funding opportunity, designated as a U01 grant, explicitly prohibits clinical trials, focusing instead on the scientific interrogation of tissue samples to advance mechanistic understanding of kidney pathology. Applicants must demonstrate expertise in advanced tissue analysis techniques, bioinformatics, and multi-omics data integration. The project is administered by the Department of Health and Human Services, with point of contact Debbie S. Gipson, MS, MD, available for inquiries. All performance activities are to be conducted in the United States, and the solicitation was posted on September 10, 2025, with no set-aside provisions indicated.