nuMoM2b Heart Health Study 3

The nuMoM2b Heart Health Study 3 is a continuation of a long-term longitudinal cohort study that originally enrolled pregnant women during their first pregnancies between 2010 and 2013 to investigate how adverse pregnancy outcomes—such as stillbirth, small-for-gestational-age birth, preterm birth, hypertensive disorders of pregnancy, and gestational diabetes—predict later cardiovascular disease. The renewed phase aims to follow these women into perimenopause and menopause, capturing critical transitions in hormonal status to better understand the interplay between pregnancy-related complications and long-term cardiovascular health. The study leverages extensive, prospectively collected clinical data and biospecimens to deepen insights into the mechanisms linking reproductive health to heart disease. This contract opportunity seeks a single coordinating center to manage all aspects of the study’s continuation, including the ongoing storage, maintenance, and potential expansion of biological samples and data assets, as well as coordination of subcontracts to support necessary research activities. The National Institutes of Health, through the National Heart, Lung, and Blood Institute, is issuing this forecast for an IDIQ contract to ensure seamless infrastructure and operational continuity. Roxane Burkett serves as both the program point of contact and the contracting officer, with the NAICS code 541715 indicating the work falls under research and development in the biological sciences. The study's next phase represents a vital effort to uncover how pregnancy history influences women’s cardiovascular risk across the lifespan, particularly during key hormonal transitions.