nuMoM2b Heart Health Study 3

The nuMoM2b Heart Health Study is a multi-center longitudinal cohort investigation initiated between 2010 and 2013 that enrolled women during their first pregnancies to examine adverse pregnancy outcomes and their subsequent effects on cardiovascular health. The current contract renewal aims to extend follow-up of this well-characterized cohort, with prospective collection of data and biospecimens to deepen understanding of the links between specific adverse pregnancy outcomes—such as stillbirth, small-for-gestational-age births, preterm birth, hypertensive pregnancy disorders, and gestational diabetes—and cardiovascular disease. This continued study is particularly focused on tracking participants as they transition into perimenopause and menopause, critical periods for assessing how hormonal changes combined with pregnancy history influence long-term heart health. The contract involves a competitive process for an Indefinite Delivery Indefinite Quantity (IDIQ) agreement to establish the nuMoM2b Coordinating Center, which will oversee all necessary activities including management, storage, and maintenance of existing and newly collected biological samples and data throughout the project period. Subcontracts will support these efforts to ensure comprehensive data stewardship and research operations. The National Institutes of Health is the overseeing agency, with designated points of contact available for programmatic and contracting inquiries.