This Solicitation opportunity from Department Of Health And Human Services was posted on May 4, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

Top

One Comprehensive Universal Radiotherapy for Everyone (1-CURE)

Closed

ARPA-H-SOL-26-147Federal

Submission Closed05/23/2026, 03:59:00 AM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

Active Opportunities Like This One

NAICS: 541714

New

Federal

Human Hindbrain Organoid Functional Assay Services.

Solicitation # RFQ_CDR-2026-135968

The U.S. Food and Drug Administration, through the Center for Drug Evaluation and Research, intends to award a sole-source, firm-fixed-price purchase order to OrganoTherapeutics SARL for human iPSC-derived hindbrain organoid functional assay services. This acquisition, conducted under FAR Part 12 as a commercial service, aims to support in vitro research on drug-induced effects on respiratory-relevant neural circuits. The scope of work includes the provision of human hindbrain organoids and associated culture materials, with twelve scheduled deliveries to the FDA White Oak Campus in Silver Spring, Maryland. The first delivery will consist of 96 organoids, followed by eleven subsequent deliveries of 48 organoids each. The contractor will perform functional characterization at its own laboratory using three-dimensional multi-electrode array technology to assess electrophysiological responses to FDA-identified drug and reversal-agent combinations. Key deliverables include the raw and analyzed data, analysis files, and comprehensive study reports. The anticipated period of performance is 18 months from the date of award. Award will be based on best value, with technical capability and past performance weighted more heavily than price. All invoicing must be processed electronically through the U.S. Department of Treasury's Invoice Processing Platform.

FDA Office Of Acq Grant Svcs

POSTED

DEADLINE

Hypoxia Chamber Services

Solicitation # 80JSC026Q0008

NASA Johnson Space Center is soliciting combined synopsis and request for quotations under solicitation 80JSC026Q0008 for Hypoxia Chamber Services to support the Artemis Program. The objective is to investigate the physiological, cognitive, and clinical effects of mild hypobaric hypoxia through two 7-day test protocols involving continuous habitation for six subjects at air equivalent altitudes of 7,000 and 9,500 feet. The scope of work encompasses the provision of infrastructure, personnel, training, materials, and operational support. The contract is structured as a firm fixed price agreement with a base period from September 15, 2026, to September 30, 2027, and multiple option periods extending through March 1, 2030. The acquisition is open to all responsible sources under NAICS code 541714, with a size standard of 1,000 employees. Evaluation is based on a trade-off process where technical acceptability and past performance are significantly more important than price. Proposals must be submitted via email to the designated points of contact by October 1, 2026, following an extension granted in Amendment 0004. Key requirements include the submission of FAR 52.212-3 representations and certifications and adherence to specific submission criteria regarding team qualifications and risk assessment. The contract also incorporates strict guidelines regarding the protection of sensitive information and restrictions on funding activities with China.

NASA Johnson Space Center

POSTED

DEADLINE

Hypobaric Chamber Pilot Studies

Solicitation # 80JSC026Q0006

NASA Johnson Space Center is soliciting quotes under solicitation 80JSC026Q0006 for pilot hypobaric chamber testing facilities to support decompression sickness research. The primary objective is to validate non-NASA resources for safe prebreathe procedures and extravehicular activity to support Artemis mission planning. The base requirement consists of three test days, with a minimum of two subjects per day, collecting and recording data according to research protocols. The contract also includes six optional work items, including additional test days, inflight-like treatment preparation, elevated metabolic rate testing, pharmaceutical-enhanced prebreathe, and body temperature studies. The base period of performance runs from September 1, 2026, to September 30, 2027, with various option periods extending through March or September 2029. This is a small business set-aside acquisition under NAICS code 541714. Awards will be made based on a trade-off analysis where technical acceptability and past performance are significantly more important than price. Technical evaluation focuses on facility capabilities, medical support, team expertise, and the proposed schedule for subject throughput. Offerors must provide a price quotation using the provided pricing sheet, and quotes must remain valid for at least 90 days. Following several amendments, the final deadline for the submission of offers is October 1, 2026, at 1:00 p.m. Central Time. All submissions must be sent electronically to the designated points of contact.

NASA Johnson Space Center

POSTED

DEADLINE

Undiagnosed Diseases Network (UDN) Diagnostic Research Innovation CenterThe National Institutes of Health, through the NINDS, is forecasting the establishment of a Diagnostic Research Innovation Center to support the next phase of the Undiagnosed Diseases Network. This center will operate as part of a broader ecosystem including the Clinical and Data Coordinating Center, Networks of Diagnostic Excellence, and the NIH Undiagnosed Diseases Program. The primary objective of the center is to advance innovative diagnostic tools and strategies for both genomic and non-genomic conditions, which includes the systematic re-evaluation of unsolved cases from previous network phases. The center will focus on generating and testing diagnostic hypotheses by utilizing advanced sequencing, multi-omics, and gene function studies in animal and human in vitro models. By collaborating with various network stakeholders, the center aims to identify novel disease-associated genes, genomic variants, and new syndromes. This initiative seeks an integrated center featuring investigators with a history of scientific synergy and collaboration. While this is currently a forecast to allow potential applicants time to plan and establish partnerships, formal applications are not yet being solicited.

National Institutes Of Health

POSTED

DEADLINE

study entitled “Malaria and vector borne disease surveillance in the Colombia/Venezuela border”

Solicitation # ERP_1301373256

The Naval Medical Research Unit South in Lima, Peru, is seeking a provider to conduct a study focused on malaria and vector borne disease surveillance along the Colombia and Venezuela border. While the government has identified the Administrators of Tulane Educational Fund as the only vendor currently capable of supporting the entire requirement, they are issuing this notice to identify other capable sources before proceeding with a sole source award under FAR 13.106-1(b)(i). Interested parties must submit a capability statement including technical, management, and cost data to Genaro Vasquez via email by 12:00 PM local time on September 18, 2026. Submissions must be in Microsoft Word or PDF format, not exceed five pages, and use the subject line ERP_1301373256. The government will use these submissions to determine whether to pursue a competitive procurement or move forward with the intended sole source contract.

Naval Medical Research Center

POSTED

DEADLINE

Cryo-Electron Microscopy (Cryo-EM) Services

Solicitation # 75N98026Q01177

The National Institutes of Health Olao, under the Department of Health and Human Services, is seeking providers for Cryo-Electron Microscopy (Cryo-EM) Services under solicitation number 75N98026Q01177. This combined contract opportunity is categorized under NAICS code 541714 and is managed by the office located in Bethesda, Maryland. Interested parties must submit their responses by the deadline of September 16, 2026, at 6:00 PM. The primary point of contact for this procurement is Roxane S. Burkett.

National Institutes Of Health Olao

POSTED

DEADLINE

TIDAL: Target-Induced Droplet Assembly of Ligands

Solicitation # S-197478

Developed by Los Alamos National Laboratory, TIDAL (Target-Induced Droplet Assembly of Ligands) is a programmable protein-only material that utilizes nanobodies fused with encapsulation peptides to create dynamic, liquid-like droplets through phase separation. This technology allows for the precise concentration of binders upon encountering a target ligand, enabling a versatile platform for resin-free protein purification, high-sensitivity diagnostics, and the creation of slow-release drug depots. It can also function intracellularly to sequester and neutralize harmful proteins associated with viral infections or cancer. The technology is currently at TRL 3 with a patent pending and is available for exclusive or non-exclusive licensing through the Department of Energy contractor, Triad. Key market applications span biopharmaceutical manufacturing, therapeutics, and biotechnology. Interested parties can contact Caleb Ledgerwood or Lindsay Augustyn via the provided licensing email to explore commercial partnerships for this innovation.

Triad - DOE Contractor

POSTED

DEADLINE

Master Protocol Development & Adaptive Design

POSTED

DEADLINE

Phase I/II Clinical Trial Management & Execution

POSTED

DEADLINE

Chemical, Biological, Radiological and Nuclear Advance Defense Enabling Network and Clinical Capability (CADENCC)

Solicitation # W911SR-26-9-CADENCC

The Department of the Army, through the Army Contracting Command Edgewood Contracting Division and the Joint Project Lead Enabling Technologies, is seeking preproposals for the Chemical, Biological, Radiological and Nuclear Advance Defense Enabling Network and Clinical Capability project. This initiative aims to accelerate clinical trial startups for CBRN defense readiness by implementing Master Protocols, utilizing innovative technologies for decentralized trial operations, and establishing a pre-positioned clinical trial site network. The project will primarily focus on Phase I and Phase II clinical trials for early treatment products, post-exposure prophylaxis, and pre-exposure prophylaxis, including those under the Animal Rule. This opportunity is issued under 10 USC 4022 Other Transaction Authority for a prototype project, with the potential for non-competitive follow-on production contracts for successful performers. Preproposals are due by 1500 hours on September 17, 2026, and must be limited to 10 pages. Evaluation will be based on technical merit, military relevance, technology readiness level 4 or above, regulatory compliance with FDA guidelines, and best overall value. Prospective awardees must be registered in the System for Award Management database.

POSTED

DEADLINE

Rapid Prototyping and Hardware EngineerThis subcontract with the Defense Advanced Research Projects Agency focuses on the design, development, and manufacturing of next-generation military hardware for prime contractors. The scope of work involves executing rapid prototyping and scalable deployment strategies through the use of additive manufacturing and high-fidelity testing environments. Key deliverables include hardware prototypes, technical design documents, and comprehensive manufacturing scalability plans. The project requires strict adherence to NIST SP 800-171 and DoDI 8582.01 standards to ensure the protection of Controlled Unclassified Information. Classified under NAICS code 541714, the opportunity was posted on September 3, 2026, with a response deadline of June 1, 2027.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

Solicitation # DARPA-SN-26-121

The Defense Advanced Research Projects Agency's Biological Technologies Office is hosting a Proposers Day for the High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators program. This event is scheduled for September 25, 2026, from 12:00 PM to 5:00 PM Eastern Time at the SPA Arlington Research Collaboration Center in Arlington, Virginia. While a hybrid option is available for attendees, all presenters are required to be present in person. Interested parties must complete advance registration by the response deadline of September 18, 2026. This special notice, identified by solicitation number DARPA-SN-26-121 and NAICS code 541714, serves as a preparatory step for a planned Program Announcement. Primary coordination for the event is managed by Dr. Abhishek Singharoy.

Defense Advanced Research Projects Agcy

POSTED

9 days ago

DEADLINE

in 7 days

AI Contract Overview

The Advanced Research Projects Agency for Health (ARPA-H) is seeking innovative proposals under the Innovative Solutions Opening ARPA-H-SOL-26-147 for its One Comprehensive Universal Radiotherapy for Everyone (1-CURE) Program, with the intent to award multiple Other Transaction (OT) Agreements. Proposals must be structured into four volumes: Volume I includes the technical and management plan with Target Product Profiles (TPP) as Element H, while Element I has been renamed to Milestone Payment Schedule (MPS), to be submitted using the format specified in Appendix I, Attachment 3; Volume II contains the cost proposal with no page limit on Cost and Pricing Data Support; Volume III covers administrative and policy requirements including organizational conflict of interest disclosures, biographical sketches, current and pending support, and certifications regarding research compliance, tax liabilities, and foreign affiliations; and Volume IV is a draft OT agreement response. Amendments have refined the structure by adding Appendices A through K, incorporating a new Cost Proposal Spreadsheet with Resource Sharing, and aligning biographical and support documents to be submitted during negotiation rather than at initial proposal submission. Proposals must adhere to strict formatting rules including 11-point Arial font, one-inch margins, and page numbering, with Volume I capped at 20 pages excluding certain sections. Key personnel must complete required forms and undergo security assessments, and all proposals must disclose any prior or current support to ARPA-H, which triggers mandatory Organizational Conflict of Interest mitigation plans. Proposals must also comply with national security protocols, handle sensitive information per 32 CFR § 2002, and adhere to a salary cap at the Executive Level II rate. Evaluation will focus on scientific and technical merit, proposer capabilities, and alignment with ARPA-H’s mission, though no formal weights or basis of award method are specified. The response deadline is May 23, 2026, and proposers are directed to monitor the 1-CURE FAQ page for updates. All proposals must include a Data Management and Sharing Plan in the NIH 6-Element format not exceeding two pages, and must have a valid Unique Entity Identifier and CAGE code. No physical delivery location or payment office details are finalized, and all critical administrative, financial, and contact information remains placeholder text to be completed upon award.

General Info

ARPA-H invites proposals for 1-CURE radiotherapy program, multiple OT agreements expected.

Agency

Department Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)View Agency

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)View NAICS

Place of Performance

Set-Aside

NONE

Documents

(17)

APPENDIX B: Full Proposal Content and Instructions for ARPA-H-SOL-26-147

DOCX•sow

Appendix K-1 CURE Gantt Chart Sample

XLSX•sow

ARPA-H-SOL-26-147 Solution Summary Content and Instructions

DOCX•sow

APPENDIX I DRAFT OTHER TRANSACTION AGREEMENT ARPA-H

DOCX•contract-document

APPENDIX B: Full Proposal Content and Instructions for ARPA-H-SOL-26-147

DOCX•sow

Appendix H: Dangerous Gain of Function Assessment for 1-CURE Proposal

DOCX•sow

Appendix J-1 Cure Cost Proposal Spreadsheet Teaming Version 1.06.02

XLSX•cost-proposal-spreadsheet

ARPA-H ISO 1-CURE Innovative Solutions Opening ARPA-H-SOL-26-147 REV1

DOCX•iso

APPENDIX C: 1-CURE Target Product Profile Guidelines

DOCX•sow

Appendix F: Administrative & National Policy Requirements Document Rev1

DOCX•sow

NIH Data Management and Sharing Plan Guidance

DOCX•sow

Appendix L-1 Cure Cost Proposal Spreadsheet Resource Sharing

XLSX•cost-proposal-spreadsheet

ARPA-H 1-CURE Solution Summary Submission Instructions

DOCX•sow

Appendix D: Task Description Document Template

DOCX•sow

Appendix F: Administrative & National Policy Requirements Document

DOCX•sow

ARPA-H SOL-26-147 1-CURE Innovative Solutions Opening

PDF•iso

APPENDIX-G-1-CURE-SECURITY-ATTESTATION-FORM.docx

DOCX

AI Contract Breakdown

Uniform Contract Format

Timeline

4 updates

PhaseClosed

PostedMar 16

Solicitation

Amendment 1Apr 14

Contract was updated

Amendment 2Apr 16

Contract was updated

Amendment 3Apr 29

Contract was updated

Amendment 4May 4

Contract was updated

Response DeadlineMay 23

Deadline has passed

Submission Closed

05/23/2026, 03:59:00 AM UTC

Find active opportunities like this

Start your free trial to discover similar active contracts, track opportunities, and build proposals with AI assistance.

Organization & Contact Information

AgencyDepartment Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)

Contacts1 person available

OfficeWashington, DC, 20005, USA

Organization / Agency

Department Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)

View Agency Profile

Office AddressWashington, DC, 20005, USA

Contacts

The 1-CURE Team

contact@example.gov

Full Description

Amendment 4: Revised Appendix B: Full Proposal Content and Instructions to consistently state that Volume I, Element H is the Target Product Profiles (TPP). Appendix B Volume I, Element I was renamed to Milestone Payment Schedule (MPS) and clarifies that the provided format in Appendix I, Attachment 3 is to be used. Appendix B Volume II Cost and Pricing Data Support page limit was removed. Appendix L: Cost Proposal Spreadsheet with Resource Sharing has been added to the attachments.

Amendment 3: Revised Appendix F: Administrative & National Policy Requirements Document, Section 3, Paragraph 1, to state that the Biographical Common Form, the Current and Pending (other) Support Common Form, and the Collaborators and Other Affiliations attachments may be provided during the negotiation phase after proposal selection.

Amendment 2: Added Appendices J & K under the Attachments section.

Amendment 1: Added Appendices A - I separately under the Attachments section.

The Advanced Research Projects Agency for Health (ARPA-H) is posting this Innovative Solutions Opening (ISO) in support of the One Comprehensive Universal Radiotherapy for Everyone (1-CURE) Program. ARPA-H anticipates that multiple Other Transaction (OT) Agreements will result from this announcement.

Interested parties are invited to review the attached 1-CURE_ISO_ARPA-H-SOL-26-147 and its Appendices A - C.

Additionally, proposers are encouraged to review the separate Special Notice, ARPA-H-SN-26-152, for information regarding the 1-CURE Proposers’ Day. Special Notice, ARPA-H-SN-26-152, is an independent announcement and is not attached to this ISO announcement.

All questions submitted to the ISO will be compiled and addressed. All answers will be posted to the 1-CURE Frequently Asked Questions (FAQ) page. Potential proposers are encouraged to monitor the FAQs page regularly for the latest information and updates: https://arpa-h.gov/explore-funding/programs/1-cure/faqs