This Solicitation opportunity from Department Of Health And Human Services was posted on May 4, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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One Comprehensive Universal Radiotherapy for Everyone (1-CURE)

Closed

ARPA-H-SOL-26-147Federal

Submission Closed05/23/2026, 03:59:00 AM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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NAICS: 541714

New

International

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High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)

Solicitation # DARPA-PA-27-01

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Defense Advanced Research Projects Agcy

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DEADLINE

Pharmacology and Pain Drug Development SMEThis subcontract opportunity through the Department of Health and Human Services Omas Strategic Buying Center seeks a subject matter expert in pharmacology and pain to support prime contractors on NIH HEAL Initiative projects. The selected expert will provide executive-level guidance on small molecule and biologic therapeutics, focusing on drug discovery and pharmacology-related trials for nervous system conditions. Key responsibilities include performing strategic programmatic reviews, evaluating milestones, and providing mentorship. The role requires the delivery of strategic recommendations and milestone evaluations through formal committee reports. Performance will take place in Bethesda, and the opportunity is categorized under NAICS code 541714. Interested parties should note the response deadline of November 3, 2026.

Omas Strategic Buying Center - Professional Services

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DEADLINE

Precision Prevention & Biological Pathway ResearchThe Precision Prevention and Biological Pathway Research subcontract supports prime contractors on Defense Health Agency Alzheimer’s Research Program projects. The primary objective is to conduct research linking service-related exposures to AD/ADRD biological pathways by quantifying military-relevant risk factors. This technical work involves the use of proteomics tools and genomic sequencing to map these biological pathways, culminating in the delivery of detailed research reports and data. Performance of this contract takes place in Frederick, Maryland, under NAICS code 541714. Due to the nature of the study, the contractor must obtain IRB approval and maintain all necessary Human Subjects Research certifications. Interested parties should note the response deadline of December 4, 2026.

Defense Health Agency

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DEADLINE

Blood-Based Biomarker Validation & ScalingThis subcontract focuses on the validation and scaling of blood-based biomarkers to support prime contractors within the Defense Health Agency Alzheimer’s Research Program. The scope of work involves performing detailed laboratory analysis of blood samples, validating the sensitivity and specificity of assays, and establishing scalable testing protocols. These operations must utilize Simoa equipment and biobanking systems while adhering strictly to GLP standards and maintaining CLIA certification. The project is managed under the Department of Defense and is centered in Frederick, Maryland. The primary objective is the delivery of validated, scalable biomarker assays and protocols to advance research goals. Interested parties should note the response deadline of December 4, 2026, and the classification of the work under NAICS code 541714.

Defense Health Agency

POSTED

DEADLINE

RFI Alzheimer’s Research Program (AZRP) Public

Solicitation # HT9427RFI2027AZRP

The Defense Health Agency, through the Congressionally Directed Medical Research Programs, has issued a Request for Information under solicitation number HT9427RFI2027AZRP to gather strategic feedback for the fiscal year 2027 Alzheimer’s Research Program. The primary objective is to identify research focus areas and funding opportunities aimed at mitigating the impact of Alzheimer's and related dementias, specifically those associated with traumatic brain injury, military service, and diverse risks. The program seeks to improve the quality of life for Service Members, Veterans, and their families by funding solution-oriented research, including the development of digital and blood-based biomarkers for early diagnosis and the creation of precision prevention strategies. This action is strictly for information and planning purposes and does not constitute a formal solicitation, request for proposals, or request for quotations. No contracts will be awarded based on this announcement, and FY27 funds have not yet been appropriated. Interested parties from academia, industry, non-profit organizations, and federal agencies are invited to provide feedback via Survey Monkey by December 4, 2026. Respondents are cautioned not to submit proprietary or sensitive information through the survey portal as it cannot be protected. The effort is categorized under NAICS code 541714 and is managed by the Department of Defense in Fort Detrick, Maryland.

Defense Health Agency

POSTED

DEADLINE

Traumatic Brain Injury and Psychological Health Research Program Public Request for Information

Solicitation # HT9427RFI2027TBIPHRP

The Defense Health Agency, under the Department of Defense and the Congressionally Directed Medical Research Programs, has issued a Request for Information under solicitation number HT9427RFI2027TBIPHRP. This action is strictly for strategic planning and is not a formal solicitation, request for proposals, or request for quotations. The primary objective is to gather feedback from academia, industry, non-profit organizations, and the public to inform the research focus areas and funding opportunities for the fiscal year 2027 Traumatic Brain Injury and Psychological Health Research Program. The program aims to optimize the prevention, assessment, and treatment of psychological health conditions and traumatic brain injuries to benefit Service Members, Veterans, and the general public. Interested parties are asked to provide input on research gaps and funding priorities, specifically regarding the prevention, screening, diagnosis, and treatment of these conditions. Responses must be submitted via Survey Monkey by December 11, 2026. Because the government cannot protect proprietary or sensitive information submitted through the survey platform, such data should not be included. This inquiry does not commit the program to incorporating the feedback into future funding opportunities, and no contract will be awarded based on this specific announcement. All inquiries regarding this RFI should be directed to Patrick M. Younkins.

Defense Health Agency

POSTED

DEADLINE

Request for Proposals (RFP) - BARDA Vaccine Medical Countermeasures for Pandemic Influenza Preparedness & Response

Solicitation # 75A50126R00001_RFP_NPIVS_27

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Barda - Aspr / Daappo / Barda Dcma

POSTED

DEADLINE

USDA SBIR/STTR Topic 8.2 — Plant Production and Protection - Biology

Solicitation # USDA-NIFA-TOPIC-8.2

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National Institute of Food and Agriculture

POSTED

DEADLINE

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Solicitation # 75N98027R00005

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National Institutes Of Health Olao

POSTED

DEADLINE

Q--AMPLICON SEQUENCING SERVICES

Solicitation # 140G0226Q0047

The Department of the Interior, through the USGS OAG Denver Acquisition Branch, is soliciting quotations for a Blanket Purchase Agreement (BPA) to provide next-generation amplicon sequencing services for the Michigan Bacteriological Research Laboratory. The agreement has a not-to-exceed value of $250,000 over a five-year period of performance from September 17, 2026, to September 16, 2031. The scope of work includes non-personal services such as library preparation for 16S V4 amplicon sequencing, library pooling, and sequencing using Illumina MiSeq or AVITI platforms to support research on bacterial pathogens, antibiotic resistance, and microbial ecology. Key deliverables include demultiplexed raw data and reporting metrics, with a required delivery turnaround of 60 business days from sample receipt. Award decisions will be based on technical and priced factors, with non-priced factors carrying significantly more weight. Technical evaluations will focus on the contractor's on-site equipment, personnel experience, quality control procedures, business establishment, and a capabilities narrative. Offerors must also provide two customer references from the last five years. The contract is subject to various federal regulations, including specific security prohibitions regarding certain telecommunications equipment and the requirement for electronic invoicing through the Invoice Processing Platform System. Quotations are due by November 5, 2026, and must be submitted via email to the primary point of contact.

Ofc Of Acquisition Grants-Denver

POSTED

DEADLINE

ARPA-H Emerging Health Innovators (EHI) Initiative

Solicitation # ARPA-H-SOL-26-150

The Advanced Research Projects Agency for Health (ARPA-H) Emerging Health Innovators (EHI) initiative, solicitation ARPA-H-SOL-26-150, seeks to identify and engage early-career investigators to develop cutting-edge biomedical, health, and community-engaged research. This opportunity is open to researchers from academic, nonprofit, and industry organizations, provided the Principal Investigator is within eight years of completing their first terminal degree. The initiative covers 16 specific topic areas, including AI in life sciences, brain stimulation, and human tissue platforms. Awards are issued as Other Transaction (OT) agreements, which are not subject to the Federal Acquisition Regulation (FAR). The selection process is a two-step submission involving an initial anonymized Solution Summary and a subsequent Full Proposal for selected candidates. Successful awards have a total value not to exceed 1,050,000 dollars over a three-year period, consisting of a 24-month base period capped at 700,000 dollars and an optional 12-month Director's Award period capped at 350,000 dollars. Payments are structured as fixed payments triggered by the completion of 12 discrete, measurable milestones. Full proposals are evaluated based on technical merit, innovativeness, feasibility, alignment with the ARPA-H mission to accelerate health outcomes, and price reasonableness. Administrative requirements include mandatory registration in SAM.gov and the use of the ARPA-H Solutions site for all submissions. Proposers must adhere to strict formatting templates for technical and management proposals, milestone schedules, and national policy requirements, including disclosures regarding organizational conflicts of interest and research security. Performance is monitored through a formal inspection and acceptance process where the government reviews deliverables within 14 calendar days. The tentative award start date is June 30, 2027, with full proposals due by February 10, 2027.

Advanced Research Projects Agency For Health (arpa-H)

POSTED

6 days ago

DEADLINE

in 3 months

AI Contract Overview

The Advanced Research Projects Agency for Health (ARPA-H) is seeking innovative proposals under the Innovative Solutions Opening ARPA-H-SOL-26-147 for its One Comprehensive Universal Radiotherapy for Everyone (1-CURE) Program, with the intent to award multiple Other Transaction (OT) Agreements. Proposals must be structured into four volumes: Volume I includes the technical and management plan with Target Product Profiles (TPP) as Element H, while Element I has been renamed to Milestone Payment Schedule (MPS), to be submitted using the format specified in Appendix I, Attachment 3; Volume II contains the cost proposal with no page limit on Cost and Pricing Data Support; Volume III covers administrative and policy requirements including organizational conflict of interest disclosures, biographical sketches, current and pending support, and certifications regarding research compliance, tax liabilities, and foreign affiliations; and Volume IV is a draft OT agreement response. Amendments have refined the structure by adding Appendices A through K, incorporating a new Cost Proposal Spreadsheet with Resource Sharing, and aligning biographical and support documents to be submitted during negotiation rather than at initial proposal submission. Proposals must adhere to strict formatting rules including 11-point Arial font, one-inch margins, and page numbering, with Volume I capped at 20 pages excluding certain sections. Key personnel must complete required forms and undergo security assessments, and all proposals must disclose any prior or current support to ARPA-H, which triggers mandatory Organizational Conflict of Interest mitigation plans. Proposals must also comply with national security protocols, handle sensitive information per 32 CFR § 2002, and adhere to a salary cap at the Executive Level II rate. Evaluation will focus on scientific and technical merit, proposer capabilities, and alignment with ARPA-H’s mission, though no formal weights or basis of award method are specified. The response deadline is May 23, 2026, and proposers are directed to monitor the 1-CURE FAQ page for updates. All proposals must include a Data Management and Sharing Plan in the NIH 6-Element format not exceeding two pages, and must have a valid Unique Entity Identifier and CAGE code. No physical delivery location or payment office details are finalized, and all critical administrative, financial, and contact information remains placeholder text to be completed upon award.

General Info

ARPA-H invites proposals for 1-CURE radiotherapy program, multiple OT agreements expected.

Agency

Department Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance

Set-Aside

NONE

Documents

APPENDIX B: Full Proposal Content and Instructions for ARPA-H-SOL-26-147

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APPENDIX B: Full Proposal Content and Instructions for ARPA-H-SOL-26-147

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APPENDIX C: 1-CURE Target Product Profile Guidelines

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Appendix D: Task Description Document Template

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Appendix F: Administrative & National Policy Requirements Document

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Appendix F: Administrative & National Policy Requirements Document Rev1

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Appendix H: Dangerous Gain of Function Assessment for 1-CURE Proposal

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APPENDIX I DRAFT OTHER TRANSACTION AGREEMENT ARPA-H

contract-document

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Appendix J-1 Cure Cost Proposal Spreadsheet Teaming Version 1.06.02

cost-proposal-spreadsheet

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Appendix K-1 CURE Gantt Chart Sample

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Appendix L-1 Cure Cost Proposal Spreadsheet Resource Sharing

cost-proposal-spreadsheet

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ARPA-H 1-CURE Solution Summary Submission Instructions

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ARPA-H ISO 1-CURE Innovative Solutions Opening ARPA-H-SOL-26-147 REV1

iso

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ARPA-H SOL-26-147 1-CURE Innovative Solutions Opening

iso

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ARPA-H-SOL-26-147 Solution Summary Content and Instructions

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NIH Data Management and Sharing Plan Guidance

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APPENDIX-G-1-CURE-SECURITY-ATTESTATION-FORM.docx

AI Contract Breakdown

Uniform Contract Format

Timeline

4 updates

PhaseClosed

PostedMar 16

Solicitation

Notice updatedApr 14

The notice description changed.

Notice updatedApr 16

The notice description changed.

Notice updatedApr 29

The notice description changed.

Notice updatedMay 4

The notice description changed.

Response DeadlineMay 23

Deadline has passed

Submission Closed

05/23/2026, 03:59:00 AM UTC

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)

Contacts1 person available

OfficeWashington, DC, 20005, USA

Organization / AgencyDepartment Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)

Office AddressWashington, DC, 20005, USA

Contacts

The 1-CURE Team

contact@example.gov

Full Description

Amendment 4: Revised Appendix B: Full Proposal Content and Instructions to consistently state that Volume I, Element H is the Target Product Profiles (TPP). Appendix B Volume I, Element I was renamed to Milestone Payment Schedule (MPS) and clarifies that the provided format in Appendix I, Attachment 3 is to be used. Appendix B Volume II Cost and Pricing Data Support page limit was removed. Appendix L: Cost Proposal Spreadsheet with Resource Sharing has been added to the attachments.

Amendment 3: Revised Appendix F: Administrative & National Policy Requirements Document, Section 3, Paragraph 1, to state that the Biographical Common Form, the Current and Pending (other) Support Common Form, and the Collaborators and Other Affiliations attachments may be provided during the negotiation phase after proposal selection.

Amendment 2: Added Appendices J & K under the Attachments section.

Amendment 1: Added Appendices A - I separately under the Attachments section.

The Advanced Research Projects Agency for Health (ARPA-H) is posting this Innovative Solutions Opening (ISO) in support of the One Comprehensive Universal Radiotherapy for Everyone (1-CURE) Program. ARPA-H anticipates that multiple Other Transaction (OT) Agreements will result from this announcement.

Interested parties are invited to review the attached 1-CURE_ISO_ARPA-H-SOL-26-147 and its Appendices A - C.

Additionally, proposers are encouraged to review the separate Special Notice, ARPA-H-SN-26-152, for information regarding the 1-CURE Proposers’ Day. Special Notice, ARPA-H-SN-26-152, is an independent announcement and is not attached to this ISO announcement.

All questions submitted to the ISO will be compiled and addressed. All answers will be posted to the 1-CURE Frequently Asked Questions (FAQ) page. Potential proposers are encouraged to monitor the FAQs page regularly for the latest information and updates: https://arpa-h.gov/explore-funding/programs/1-cure/faqs