PRISM Pooled Cancer Cell Line Assay Execution
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The contract calls for the execution of a 5-day Luminex-format viability assay using the PRISM platform to evaluate a compound’s effect across approximately 900 barcoded cancer cell lines. The assay will utilize an 8-point, 3-fold dilution series to generate dose-response data, enabling precise measurement of cellular viability under varying concentrations of the compound. All work must be conducted with high technical rigor to ensure the generation of high-quality, reproducible viability data suitable for downstream analysis. The deliverables include comprehensive viability profiles for each cell line and detailed correlation analyses that link compound sensitivity to cellular and genetic characteristics across the panel. The project is structured as a subcontract under the National Institutes of Health, part of the Department of Health and Human Services, with the North American Industry Classification System code 541715 indicating it falls under research and development in the physical, engineering, and life sciences. The solicitation was posted on August 7, 2026, and responses are due by August 24, 2026.
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