This Government Contract opportunity from Department Of Energy was posted on November 13, 2025. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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TECHNOLOGY LICENSING OPPORTUNITY: SmartBind pH Switch

Closed

S-133461Federal

Submission Closed12/06/2025, 12:00:00 AM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

Active Opportunities Like This One

NAICS: 325413

New

Federal

6550--Optilite analyzer reagents

Solicitation # 36C26227Q0052

262-NETWORK Contract Office 22 (36C262)

POSTED

DEADLINE

Supply of i-STAT PT Plus Control Reagent Level 1This subcontract involves the procurement and delivery of i-STAT PT Plus Control Reagent Level 1 for coagulation testing to support prime contractors fulfilling Department of Defense supply contracts. The scope of work requires the delivery of two boxes, each containing ten 1.0 mL units, shipped FOB Destination to a performance location in APO 96260-5479. To ensure quality and safety, all supplied reagents must adhere to Regulation 864.7750 Class II requirements and maintain full compliance with Registration, Listing, Labeling, and Good Manufacturing Practices. This requirement is managed under NAICS code 325413 for the Medical Supply Chain MD Surg FSF agency.

MEDICAL SUPPLY CHAIN MD SURG FSF

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CONTROL SET, BLOOD CHEM

Solicitation # SPE2DS-27-T-0906

Solicitation SPE2DS-27-T-0906 is a request for quotations from DLA Troop Support for two sets of DXH 500 Series Blood Chemistry Control (NSN 6550-01-688-9090). This assayed whole blood control is used to monitor multi-parameter hematology cell counters and includes abnormal low, normal, and abnormal high components. The items must be stored refrigerated and upright between 2 to 8 degrees Celsius and protected from freezing and overheating. Delivery is required within 20 days after receipt of order, with a required delivery date of October 27, 2026, under FOB Destination terms. The contract imposes strict shelf-life requirements, specifying a non-extendable shelf life of 3 months, with no more than 13 days elapsed from the date of manufacture to the date of delivery. Packaging must be commercial and compliant with RP001 and MIL-STD-2073-1E, while marking must adhere to Medical Marking Standard No. 1. Invoicing is to be processed electronically via the Wide Area Workflow system. This is not a small business set-aside, and the procurement falls under NAICS code 325413. Compliance with the Buy American and Balance of Payments Program and DFARS safeguarding of covered defense information is required.

MEDICAL SUPPLY CHAIN MD SURG FSF

POSTED

DEADLINE

CONTROL, BLOOD CHEMISTR

Solicitation # SPE2DS-27-T-0950

Solicitation SPE2DS-27-T-0950 is a Request for Quotations issued by the Department of Defense, DLA Troop Support Medical Supply Chain, for the procurement of two boxes of i-STAT PT Plus Control Reagent Level 1 (NSN 6550-01-728-5703). This reagent is used for coagulation testing and is compatible with the i-STAT PT Plus cartridge and the i-STAT 1 Government Field Kit analyzer. Each box contains ten 1.0 mL units. The required delivery date is October 23, 2026, with a delivery window of 83 days after award. Inspection and acceptance will occur at the destination per FAR 52.246-2. The contract mandates strict quality and storage requirements, including refrigeration between 2 to 8 degrees Celsius and a non-extendable shelf life of 12 months. Items must be delivered within one month of the manufacture date. Packaging must be commercial and adhere to MIL-STD-2073-1E and RP001, with marking compliant with Medical Marking Standard No. 1. Labels must include the contract/lot number and manufacture or expiration dates. The procurement is not a small business set-aside, though a HUBZone price evaluation preference may be applied. Compliance with the Buy American Act and DFARS domestic material restrictions is required, and electronic invoicing must be processed through the Wide Area WorkFlow system.

MEDICAL SUPPLY CHAIN MD SURG FSF

POSTED

DEADLINE

BPA - Consumable Supplies for Terumo Trima Accel Blood Collection systems

Solicitation # HT942627QE003

The Defense Health Agency is soliciting quotations to establish a Blanket Purchase Agreement (BPA) for the recurring resupply of consumable products for three Terumo Trima Accel Blood Collection Systems used by the USAISR Combat Casualty Care Research Team 1 in Texas. To maintain FDA approval and satisfy research protocols, the contractor must provide original manufacturer-supplied consumables, including Teruflex 500ml collection bags, Trima Platelet Kits, Isoplate Solution (PAS-F), TSCD Wafers, ACD-A Solution, and 150 mL couplers. This procurement is a 100 percent set-aside for Service-Disabled Veteran-Owned Small Businesses under NAICS 325413. The resulting BPA will have a 60-month ordering period with a total ceiling of 35 million dollars, though some documentation notes a lower limit of 350,000 dollars. Individual call orders are capped at 50,000 dollars, while Government Purchase Card orders are limited to 15,000 dollars. Awards will be made on a Lowest Price Technically Acceptable basis, with technical capability rated as pass or fail. All payment requests and receiving reports must be processed electronically through the Wide Area WorkFlow system. Quotations are due by November 6, 2026, and must be submitted in two separate volumes covering technical capability and pricing.

Army Medical Resources Acq Activity

POSTED

DEADLINE

Blood Typing Card SupplyThis subcontract opportunity is issued by the Department of Defense Medical Supply Chain for the provision of ABO RH screen Eldon cards. The selected provider will be responsible for the manufacture or distribution of these specialized blood typing cards, which utilize specific medical reagents and substrates to support prime contractors on medical supply contracts. Due to the nature of the diagnostic components, the contractor must maintain valid FDA medical device registration. The performance of this contract will take place at Fort Campbell, Kentucky. Interested parties should note that the solicitation was posted on October 22, 2026, with a response deadline of October 28, 2026. The requirement falls under NAICS code 325413, focusing on the delivery of critical diagnostic supplies to the agency.

MEDICAL SUPPLY CHAIN MD SURG FSF

POSTED

DEADLINE

Custom ArcherDX VariantPlex NGS Target-Enrichment KitsThis subcontract involves the supply of custom-designed Next-Generation Sequencing target-enrichment library preparation kits to support prime contractors on NIH NHLBI projects. The required kits must be manufactured using proprietary ArcherDX VariantPlex Anchored Multiplex PCR chemistry and pre-amplification ligation of unique molecular barcodes. To ensure operational compatibility, all delivered kits must function with Archer Analysis software and Illumina NovaSeq instruments. Managed under the National Institutes of Health Olao within the Department of Health and Human Services, the contract falls under NAICS code 325413. The procurement process began with a posting date of October 22, 2026, and established a response deadline of November 2, 2026.

National Institutes Of Health Olao

POSTED

DEADLINE

Reagents and consumables for Roche immunostainers

Solicitation # PCA-NCI-04352

The National Institutes of Health, under the Department of Health and Human Services, is issuing a Sources Sought Notice for a Firm-Fixed-Price Indefinite Delivery Indefinite Quantity (IDIQ) contract to provide reagents, consumables, and software upgrades for the Laboratory of Pathology at the Cancer Center Research. The required materials must be compatible with four Roche Ventana Medical Systems Benchmark ULTRA immunostainers to support immunohistochemical and in situ hybridization testing for cancer diagnostics and research. The contract is expected to include a base period starting December 1, 2026, and ending November 30, 2027, with four subsequent option periods. Key performance requirements include the delivery of reagents within five days of a task order, with all supplies featuring expiration dates extending more than 12 months beyond the shipping date. Reagents must be shipped overnight using dry ice, wet ice, or other industry best practices to the performance site in Bethesda, Maryland. Additionally, the contractor must provide no-cost software upgrades within one month of release, including technologist training and access to scientists and engineers for consultation. Award will be based on a best value tradeoff for offerors meeting the minimum requirements. Interested small businesses must submit a capability statement of no more than seven pages to Luz Casey by October 28, 2026.

National Institutes Of Health Olao

POSTED

DEADLINE

6550--VISN Cepheid GeneXpert Testing Supplies Base Plus 3 Op Yr RFQ

Solicitation # 36C24527Q0042

The Department of Veterans Affairs, specifically the VA North Atlantic Health Network (HSA 1.3), is soliciting a firm-fixed-price, Indefinite Delivery/Indefinite Quantity (IDIQ) contract for Cepheid GeneXpert testing supplies. This requirement covers the procurement of FDA-approved reagents, consumables, and service for PCR analyzers to detect various pathogens, including CoV-2, Influenza, RSV, MRSA, and Mycobacterium Tuberculosis. The contract is structured with a base period ending October 31, 2027, and three subsequent one-year option periods extending through October 31, 2030. Deliveries will be made to multiple VA Medical Centers across Maryland, West Virginia, and Washington DC. This acquisition is set aside for HUBZone small businesses. Award will be determined using the Lowest Price Technically Acceptable (LPTA) method, evaluating technical acceptability, delivery performance, past performance, and price, with additional credit given to certified SDVOSB or VOSB offerors. Key contractor requirements include being an authorized distributor, acknowledging orders within 24 hours, and guaranteeing a minimum four-month expiration date on reagents. Additionally, the vendor must provide an emergency plan to deliver replacement supplies within 24 hours if products are found to be defective. Invoices must be submitted electronically, and payments will be processed in accordance with the Prompt Payment Act.

245-NETWORK Contract Office 5 (36C245)

POSTED

DEADLINE

NOI - DNA Sequencing of Bone Marrow Failure Syndro

Solicitation # 75N98027Q00027

The National Institutes of Health, Office of the Director, intends to award a non-competitive, firm-fixed-price purchase order for custom-designed ArcherDX VariantPlex Next-Generation Sequencing target-enrichment library preparation kits. This acquisition, conducted under solicitation 75N98027Q00027, is designated for the NHLBI Hematology Branch to support the screening of over 200 patient samples for aplastic anemia and bone marrow failure syndromes. The government intends to negotiate with Integrated DNA Technologies, Inc. as the sole owner and manufacturer of the proprietary ArcherDX VariantPlex Anchored Multiplex PCR chemistry, which is essential for maintaining scientific continuity and compatibility with existing bioinformatics pipelines and Illumina NovaSeq instruments. The requirement falls under NAICS code 325413 and is not set aside for small businesses. The kits must feature pre-amplification ligation of unique molecular barcodes to enable error-correcting sequencing and must be delivered to Bethesda, Maryland, within an estimated turnaround time of four to six weeks after receipt of order. Proposals must be submitted by November 2, 2026, and include a Unique Entity Identifier, Taxpayer Identification Number, and business size certification. Award evaluation may consider technical capability, past performance, and lifecycle expectations, while all invoicing must be processed through the Invoicing Processing Platform using a three-way match.

National Institutes Of Health Olao

POSTED

DEADLINE

REAGENTS - MANUAL MIRCROBIOLOGY MEDIA AMD#05

Solicitation # RFB-IS-27200226

The Los Angeles County Internal Services Department is soliciting bids for the procurement of manual microbiology media reagents, a project categorized as complex. The scope includes the supply of various laboratory materials, specifically agar plates, broths, kits, and microbial strains such as KWIK-STIK and LYFO DISK derived from ATCC and NCTC. Bidders must provide quotations that explicitly state the manufacturer's brand name, part number, and packaging, while ensuring all delivered items have a minimum shelf life of three months. Deliveries are required to be F.O.B. delivered to various locations within Los Angeles County, with freight costs prepaid by the vendor. Submissions must be made electronically via the Vendor Self Service portal by the deadline of October 29, 2026. To be considered responsive, bids must include descriptive literature and all mandatory forms in Appendix A, including certifications for compliance, prevailing wages, and community business enterprise information. The County encourages participation from Small, Local Small, Disabled Veteran, Social, and Community Business Enterprises. Award evaluation may involve the review of technical specifications and the ability to meet federal administrative requirements and California state employment laws, including fair chance hiring practices and jury service pay policies. Payment for awarded contracts is primarily handled through Electronic Funds Transfer.

Internal Services Department

POSTED

DEADLINE

81627Y0873-Assays, reagents, and consumables for cobas® 5800, 6800v2, 8800v2, MagNa Pure96, and LightCycler systems

Solicitation # 81627Y0873

The New York City Department of Health and Mental Hygiene intends to enter into a six-year sole source agreement with Roche Diagnostic Corporation under solicitation 81627Y0873. This contract is for the procurement of assays, reagents, and consumables necessary to operate the cobas 5800, 6800v2, 8800v2, MagNA Pure 96, and LightCycler systems. These high-throughput automated PCR and extraction platforms are utilized by the NYC Public Health Lab to perform critical molecular testing for HIV-1/2, bloodborne pathogens such as HBV and HCV, and various sexually transmitted infections including HPV, Trichomonas, and M. Gen. The goal of this procurement is to increase testing capacity and reduce detection times to better combat rising rates of HIV and other STIs. Roche Diagnostic Corporation has been identified as the sole manufacturer and distributor of these specific materials, and only their certified service engineers are authorized to perform maintenance on these systems. The scope of work includes a wide array of assay kits, including those for SARS-CoV-2, CMV, EBV, and BKV, as well as a Research Use Only panel. Interested firms may submit an Expression of Interest via the PASSPort system by November 2, 2026, at 2:00 PM.

Department Of Health And Mental Hygiene

POSTED

7 days ago

DEADLINE

in 5 days

General Info

Agency

Department Of Energy → Triad - DOE Contractor

NAICS

325413 - In-Vitro Diagnostic Substance Manufacturing

Place of Performance

Los Alamos, NM, 87545, USA

Set-Aside

NONE

Documents

FCI-tech-summary-visual-SmartBind.png

AI Contract Breakdown

Uniform Contract Format

Contract not broken down yet

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Timeline

PhaseClosed

PostedNov 13

special-notice

Response DeadlineDec 6

Deadline has passed

Submission Closed

12/06/2025, 12:00:00 AM UTC

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Organization & Contact Information

AgencyDepartment Of Energy → Triad - DOE Contractor

Contacts2 people available

OfficeColumbus, OH, 43201, USA

Organization / AgencyDepartment Of Energy → Triad - DOE Contractor

Office AddressColumbus, OH, 43201, USA

Contacts

Marc Witkowski

contact@example.gov

Lindsay Augustyn

contact@example.gov

Full Description

This innovation from scientists at Los Alamos National Laboratory is a significant improvement on a gold standard protein purification method that gently captures and releases antibodies using mild pH changes, making antibody purification safer, more efficient, and less damaging.

The Challenge:

Purifying antibodies — vital tools in medicine and research — typically relies on a protein called Protein G that latches onto them. However, getting the antibodies back off this molecular “magnet” requires very acidic conditions, which can damage both the antibodies and Protein G itself. This harsh process risks ruining expensive materials and reducing the effectiveness of critical therapies and tests.

Problems Solved:

Researchers engineered a pH-switchable version of Protein G that uses gentle changes in acidity (pH) to control when it releases antibodies, it now binds antibodies at a mildly acidic pH and releases at a mildly basic pH — eliminating the need for harsh chemicals. This innovation protects sensitive proteins, improves efficiency, lowers costs, and opens the door for safer, greener, and more effective antibody purification in both labs and industry.

Key Advantages:

Gentle elution conditions: Antibodies are released at a mild pH (~8.2) instead of harsh acidic conditions (~2.7), reducing damage to both the antibodies and the protein itself.
Improved antibody stability and yield: Preserving antibody structure increases reliability and effectiveness, which is especially critical for therapeutic and diagnostic use.
Switchable binding mechanism: pH-sensitive histidine residues allow for a controlled "on/off" switch based on pH, improving process control and reproducibility.
Cost-effective and scalable: Reduces loss of expensive antibodies and minimizes the need for post-purification repair or replacement, saving money in industrial applications.

Market Applications:

Biopharmaceuticals
Life Sciences Research
Bioprocessing and Manufacturing Tools
Veterinary and Agricultural Biotech

Development Status: TRL 4

US Provisional / Patent No. 10,954,275

LA-UR-25-29451

LANL Tech Partnerships: Unlock the Innovative Potential

Los Alamos National Laboratory offers a wide range of cutting-edge technologies and capabilities that may provide your company with a competitive edge in the market and unlock the innovative potential that can enhance, refine, and revolutionize your products.

LANL’s licensing program focuses on moving inventions developed by our researchers to commercial innovations. Patented and patent pending inventions and copyrighted software are available to existing and start-up companies through exclusive and non-exclusive licensing agreements. For specific discussions, please contact contact@example.gov.

Note: This is not a call for external services for the development of this technology.

https://www.lanl.gov/engage/collaboration/feynman-center/partner-with-us/licensing-technology

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