The Next Generation of the Clinical and Translational Science Awards Program Trial Innovation Network

The Next Generation of the Clinical and Translational Science Awards Program Trial Innovation Network is a forecasted funding opportunity issued by the National Institutes of Health under the Department of Health and Human Services to accelerate the development and execution of multi-center clinical trials. The initiative aims to overcome systemic barriers in trial design and implementation by fostering innovation in areas such as safety monitoring, digital health technologies, genomic capacity, disease progression modeling, and leadership training. It seeks to establish a national platform for advancing the science of clinical research through scalable, efficient, and cost-effective solutions, positioning the network as both a practical engine for trial delivery and a laboratory for methodological discovery. Applications must be submitted by eligible organizations and will be evaluated through the NIH’s standard peer-review process, with funding decisions based on merit and potential impact. The opportunity is authorized under Sections 301 and 405 of the Public Health Service Act and governed by Federal Regulations 42 CFR Part 52 and 2 CFR Part 200. While no specific set-aside or NAICS code has been designated, the announcement is open to all qualified applicants who meet the eligibility criteria outlined in the full notice. The forecast was posted on July 20, 2026, and point of contact for inquiries is the Division of Clinical Innovation at NCATS, reachable via tin@nih.gov. Further details and application guidance are available through the Grants.gov portal using the provided UI link, and submissions will follow the NIH’s standard review and selection protocols.