This Government Contract opportunity from Department Of Homeland Security was posted on August 3, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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Biomarker Assay Development & Validation

Closed

Federal

Submission Closed09/02/2026, 09:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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NAICS: 541715

New

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South Dakota State Government

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Omas Strategic Buying Center - Professional Services

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CDC Office Of Acquisition Services

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Research Institution Partner (Non-Profit)This subcontract opportunity is for a registered non-profit research institution to partner with prime contractors on U.S. Air Force STTR projects. The primary objective is to conduct core scientific research to evaluate the technical feasibility of cyber resiliency within edge computing environments. Selected partners will be expected to leverage university laboratories, high-performance computing clusters, and specialized academic research software to produce research data, peer-reviewed findings, and contributions to technical reports. The opportunity is designated as a total small business set-aside under the SBIR/STTR mandate for organizations with fewer than 500 employees, falling under NAICS code 541715. Interested parties must submit their responses by November 25, 2026, at 5:00 PM. This effort is managed through the U.S. Department of Defense on behalf of the U.S. Air Force.

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Edge and Fog Computing Architecture SpecialistThis subcontract opportunity for the U.S. Air Force focuses on research and development for cyber resiliency projects, specifically targeting the design of resilient architectures for fog and edge computing devices. The selected provider will be responsible for conducting feasibility studies, establishing technical milestones, and utilizing edge gateways, fog computing nodes, and embedded hardware. Key deliverables include a technical feasibility report and a Final Scientific or Technical Report. The project is a total small business set-aside under NAICS code 541715, requiring the contractor to have fewer than 500 employees. Due to the sensitive nature of the work, strict security compliance is mandatory, including CMMC Level 2 and adherence to NIST SP 800-171 and NIST SP 800-172 standards. Responses are due by November 25, 2026.

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Quantum Algorithm & Benchmark DevelopmentThe Quantum Algorithm and Benchmark Development subcontract involves performing technical research and development for prime contractors on projects for the Defense Advanced Research Projects Agency. The scope of work focuses on developing benchmark instances for commercial application workloads, defining resource estimates, and translating high-value use cases into technical quantum algorithm requirements. These tasks will be executed using quantum computing simulators or early-stage quantum hardware, requiring specialized expertise in algorithm optimization and quantum complexity theory. The primary objective of the contract is the delivery of validated commercial application benchmarks. This opportunity is categorized under NAICS code 541715 and is associated with the Department of Defense. Interested parties should note the response deadline of December 30, 2026.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

Research Institution / University Partner (STTR)This subcontract opportunity is for a Research Institution or University Partner to support prime contractors on Department of Defense 2027 SBIR/STTR Phase I projects for the U.S. Air Force. The selected partner will be responsible for performing fundamental research, technical validation, and experiments to determine the feasibility of proposed concepts. Key deliverables include contributing to the Phase I technical volume, providing research data, and submitting detailed technical reports and feasibility findings. The solicitation was posted on October 28, 2026, with a response deadline of November 25, 2026. This is a total small business set-aside under the SBIR/STTR mandate for entities with fewer than 500 employees, falling under NAICS code 541715. The primary objective is to provide the academic and analytical rigor necessary to validate technical concepts during the initial phase of the program.

U.S. Air Force

POSTED

about 11 hours ago

DEADLINE

in 28 days

AI Contract Overview

The contract focuses on refining and validating a biological assay designed to detect biomarkers of cyanide exposure in saliva, with the goal of ensuring clinical accuracy and reliability for real-world medical and emergency response applications. The work requires optimizing the assay’s sensitivity and specificity to reliably identify trace levels of cyanide-related indicators in a non-invasive sample type, addressing challenges related to matrix interference, sample stability, and reproducibility across diverse populations. The project demands rigorous validation against established reference methods and adherence to clinical laboratory standards to support potential regulatory acceptance and deployment in forensic, occupational, or mass casualty scenarios. This subcontract, issued under NAICS code 541715 by the Department of Homeland Security’s Science and Technology Acquisition Division, is targeted toward specialized research and development firms with expertise in diagnostic assay development and biomarker validation. The solicitation was posted on August 3, 2026, with a response deadline of September 2, 2026, and no set-aside provisions are specified. Performance is expected to be conducted where the contractor’s core capabilities reside, with no specific location mandated. The project’s success hinges on delivering a clinically viable, scalable, and robust diagnostic tool that can transition from research to operational use in public health and emergency response systems.

General Info

Develop and validate a saliva-based assay for cyanide biomarkers with clinical accuracy and operational readiness for emergency response.

Agency

Department Of Homeland Security → Sci Technology Acq Division

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Set-Aside

NONE

Documents

This scope was carved out of 70RSAT26RFI000021.

The full solicitation package (1 document), including the RFP, is on the prime solicitation, not on this scope.

View the prime solicitation

Chemical Security Analysis Center (CSAC) Rapid Cyanide Detection RFI

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Timeline

PhaseClosed

PostedAug 3

subcontract

Response DeadlineSep 2

Deadline has passed

Submission Closed

09/02/2026, 09:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Homeland Security → Sci Technology Acq Division

ContactsNo contacts available

OfficeN/A

Organization / AgencyDepartment Of Homeland Security → Sci Technology Acq Division

Office AddressN/A

ContactsNo contact information available

Full Description

Refine and validate the biological assay that detects cyanide exposure biomarkers in saliva to ensure clinical accuracy and reliability.

More opportunities from Department Of Homeland Security → Sci Technology Acq Division

Same awarding agency

NAICS: 611430

New

Federal

Help Desk & User Training ServicesThis 8(a) set-aside subcontract, titled Help Desk and User Training Services, supports the Department of Homeland Security's Sci Technology Acq Division. The primary objective is to provide comprehensive end-user support and training for prime contractors working on DHS OIP Web Portal projects. The scope of work includes the delivery of Tier 1 and Tier 2 Help Desk support via ticketing systems and the creation of computer-based training modules utilizing specialized authoring tools. Key deliverables for this engagement consist of resolved support tickets and the completion of all required training materials. The opportunity is categorized under NAICS code 611430. Interested parties should note the response deadline of November 13, 2026.

Professional and Management Development Training

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5 days ago

DEADLINE

Biomarker Assay Development & Validation

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