Calcium Imaging and Electrophysiological Functional Analysis

The contract involves performing calcium imaging to study spontaneous and drug-induced calcium burst dynamics in brain organoids, with a focus on quantifying burst timing variability and assessing the neuromodulatory effects of a small molecule drug. The work requires advanced functional analysis to capture real-time intracellular calcium fluctuations, enabling characterization of neuronal network activity patterns under baseline conditions and in response to pharmacological perturbation. This research aims to generate detailed insights into how the small molecule influences emergent neural behaviors in human-derived brain organoids, supporting mechanistic understanding of neuroactive compounds. The effort is part of a subcontract under the FDA Office of Acquisition Grant Services within the Department of Health and Human Services, classified under NAICS code 541715 for research and development in the physical, engineering, and life sciences. The opportunity was posted on June 22, 2026, with a response deadline of July 6, 2026 at 5:00 PM. While no specific location or point of contact is provided, the place of performance and agency details indicate this is a federal research initiative aimed at advancing neuropharmacological assessment through cutting-edge organoid models and functional imaging techniques.