Mechanistic Disease Modeling and Simulation

The contract seeks to advance the development of integrated computational and biological models capable of simulating disease mechanisms at a systems level, with the goal of enabling accurate prediction and validation of potential therapeutic interventions. This effort requires the synthesis of multi-scale data across molecular, cellular, and tissue levels to create dynamic simulations that reflect the complexity of human disease pathways, allowing for high-throughput in silico testing of drug candidates and treatment strategies. The work must bridge advanced modeling techniques with biological realism to produce tools that can guide experimental design and accelerate therapeutic discovery. The opportunity is structured as a subcontract under the Advanced Research Projects Agency for Health, part of the Department of Health and Human Services, and is classified under NAICS code 541715 for research and development in the physical, engineering, and life sciences. The proposal submission deadline is August 6, 2026, and the posting date was May 5, 2026. While specific performance locations and points of contact are not provided, the project demands a high level of interdisciplinary expertise combining computational biology, systems modeling, and biomedical research to deliver validated predictive platforms. Success will be measured by the model’s ability to reliably simulate disease processes and support translational outcomes in a therapeutic context.