NIH Research Program Projects (Parent P01 Clinical Trial Optional)
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The National Institutes of Health is seeking investigator-initiated Program Project (P01) applications to support multidisciplinary, long-term research programs focused on a specific major scientific objective or theme. These projects must align with the scientific missions of participating NIH Institutes, Centers, and Offices to enhance health and reduce illness. Each application is required to include an administrative core and at least two research projects, with the option to include scientific cores if necessary for the research. This forecast, posted on February 11, 2026, falls under NAICS code 541715 and is administered by the Department of Health and Human Services. Awards are granted under the statutory authority of the Public Health Service Act and applicable federal regulations. Interested parties can contact the Referral Officer for further information regarding this funding opportunity.
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The National Institutes of Health (NIH) pursues its mission of seeking fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability. Through this Notice of Funding Opportunity (NOFO), the participating NIH Institutes, Centers, and Offices (ICOs) encourage pursuit of that mission through the submission of investigator-initiated Program Project (P01) applications. With this Parent P01 NOFO, the NIH ICOs intend to support a broadly based, multidisciplinary, often long-term research program with a specific major scientific objective or theme. The proposed Program Project must be related to the programmatic interests of one or more of the participating ICOs based on their scientific missions. Each application submitted in response to this NOFO must consist of at least two research projects and an administrative core. Additionally, a P01 application may include scientific cores, if needed for the proposed research. The projects included within the Program must share a common central scientific theme, focus, and/or an overall objective. Statutory authority: Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
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