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Single Source for Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium - Data Coordinating Center (DCC)

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The contract supports the continuation of the Consortium to Study Chronic Kidney Disease of Uncertain Etiology (CKDu) in Agricultural Communities (CURE), a research initiative aimed at understanding and addressing CKDu, which leads to kidney failure predominantly in rural populations of low and middle-income countries. This disease disproportionately affects young working-age individuals, with environmental exposures suspected as primary causes, alongside possible genetic factors. Insights gained from this research have implications for kidney health in the U.S. since similar risk factors are present domestically. The consortium, jointly funded by multiple NIH institutes since 2021, comprises Field Epidemiology Sites, a Renal and Environmental Science Core, and a Data Coordinating Center. This particular funding opportunity is a single-source renewal for the Data Coordinating Center, which is responsible for data management, analysis, and overall project coordination for the consortium. The Data Coordinating Center will facilitate collaboration among consortium members, enhance scientific discovery regarding the causes and progression of CKDu and associated kidney disease, and support intervention development and public health strategies. Additionally, the consortium will continue to serve as a resource for ancillary research studies. Applications for this opportunity will be peer-reviewed and funded based on merit.

General Info

Funding renewal for Data Coordinating Center managing CKDu research, data, collaboration, and interventions.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) View NAICS

Place of Performance

Not specified

Set-Aside

NONE

Documents

(0)

No documents available

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUS
Organization / Agency
Department Of Health And Human Services → National Institutes Of Health
Office AddressUS
Contacts
Division of Kidney Urologic and Hematologic Diseases
contact@example.gov
+1 (555) 000-0000

Full Description

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The purpose of this funding opportunity is to advance the NIH mission by supporting the continuation of the Consortium to Study Chronic Kidney Disease of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE). 

Chronic Kidney Disease of Uncertain Etiology (CKDu) causes kidney failure in rural areas of many Low and Middle Income Countries, resulting in a large death toll among the young working age population. Environmental factors are suspected to be causative, but family and geographic clustering add consideration of unrecognized genetic susceptibility. The risk factors identified in other countries are encountered by U.S. patients, so this research will offer valuable insights into the development and progression of tubulointerstitial renal diseases, with broad implications for understanding kidney health and disease in the U.S.

NIDDK, NIEHS, and FIC have jointly funded a consortium that includes Field Epidemiology Sites, a Renal and Environmental Science Core, and a Data Coordinating Center to find causes and potential interventions for CKDu since 2021. This NOFO requests a renewal application for the Data Coordinating Center that will provide data management and analysis, as well as overall project management for the Consortium. Consortium members will continue to collaborate to maximize scientific opportunities and enable discovery science to understand the etiologies of CKDu, the exposures that initiate and affect progression of tubulointerstitial kidney disease, potential therapeutic targets, and future opportunities for public health interventions. The CURE Consortium will serve as a resource for ancillary studies. 

This is a forecast for a single source Notice of Funding Opportunity (NOFO) that will invite application(s) from eligible organizations to apply. Application(s) will be peer-reviewed and only funded if meritorious. 

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